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  • 2000-2004  (3)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Topical imiquimod immunotherapy in the management of lentigo maligna (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 29 (2004), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Melanoma in situ of the lentigo maligna (LM) type is a precursor lesion of LM melanoma. It most commonly occurs in elderly individuals, on the head and neck. Although surgical excision is recommended, this may not be practical for large lesions at cosmetically sensitive sites. In addition, histological changes commonly extend beyond the clinical margins of the lesion. This study describes the use of imiquimod 5% cream as topical immunotherapy in the management of lentigo maligna. Twelve patients (average age 63 years, 10 female), of biopsy-proven facial LM were treated with topical imiquimod, three times a week for 6 weeks. In the absence of an inflammatory response, patients were asked to apply the treatment daily. Seven showed clearance of the LM clinically and histologically. A further three patients showed clearance histologically with persisting pigmentation due to dermal melanin and melanophages. Thus, 10 of 12 patients cleared with no relapse after a median follow-up of 6 months. Two patients failed to respond to imiquimod and their lesions were treated with surgical excision. Imiquimod was well tolerated, except in three patients who experienced an intense inflammatory response. Two of these also developed secondary infection. Imiquimod 5% cream appears to offer a potential noninvasive method for the treatment of lentigo maligna.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2004.01452.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    On dermatological surgery, registrars and residents (2002)
    Oxford, UK : Blackwell Science, Ltd
    Clinical and experimental dermatology 27 (2002), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary  Training in aspects of skin surgery is now a requirement of general dermatology registrars and residents in the UK and USA, respectively. We compare this component of the training programmes at St John's Institute of Dermatology in London and at New York Medical College in New York City. Because of their understanding of cutaneous pathology, dermatologists are often best qualified to assess patients for skin procedures and should therefore be involved, directly or indirectly, in their surgical management. In our view, the curricula should be changed to place more emphasis on the supervised assessment and treatment of patients with skin tumours as well as to reflect the growing importance of laser treatments and the demand by patients for cosmetic interventions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0307-6938.2001.00954.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Partial re-emergence of a port-wine stain following successful treatment with flashlamp-pumped dye laser (2001)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 26 (2001), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We present a 49-year-old patient with a congenital superficial vascular malformation of port-wine stain (PWS) type which has partially re-emerged in the 2.5 years since it was almost completely obliterated with the flashlamp-pumped short pulse pulsed-dye laser (FPDL). This observation is discussed with respect to the possible pathogenesis of PWS, with particular reference to the underlying autonomic nerve supply. The latter would not be expected to respond to FPDL and may explain re-emergence of the lesion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2230.2001.00756.x
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    Paper (German National Licenses)
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