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  • 1
    Online Resource
    Online Resource
    The level of physical activity and the growth hormone (GH) response to acute physical exercise
    Association of Basic Medical Sciences of FBIH ; 2004
    In:  Bosnian Journal of Basic Medical Sciences Vol. 4, No. 3 ( 2004-08-20), p. 47-49
    Details
    In: Bosnian Journal of Basic Medical Sciences, Association of Basic Medical Sciences of FBIH, Vol. 4, No. 3 ( 2004-08-20), p. 47-49
    Abstract: There is no clear evidence about the influence of programmed physical activity (training) on growth hormone (GH) response to acute physical exercise. The aim of this study was to estimate the relationship between the level of physical activity and the serum growth hormoneconcentration in response to acute physical exercise. The study was performed on 20, healthy male subjects. Based on the level of their physical activities they were divided in two groups of equal size: group 1, trained, and group 2, untrained subjects. All subjects performed one boot of exercise on cycle ergometer, lasting 30 minutes. Work intensity was approx. 65% of VO2 max, and the rate of cycling was 60/min. Serum GH concentrations were measured by IRMA (immunoradiometric assays) method in blood samples obtained in the period of rest, during exercise and in the recovery period. There were marked differences in the dynamics of changes in the serum GH concentrations during exercise period between the groups of various level of physical activity despite the lack of the significant differences in basal level and maximal level of serum GH concentration at the end of exercise. Untrained subjects showed faster increase in serum GH concentration than trained subjects, but in trained subjects the restoration of the basal values in the recovery period was faster. These results indicate that the level of physical activities in young, healthy male subjects has no influence on GH response to acute physical exercise.
    Type of Medium: Online Resource
    ISSN: 1840-4812 , 1512-8601
    URL: Article
    DOI: 10.17305/bjbms.2004.3393
    Language: Unknown
    Publisher: Association of Basic Medical Sciences of FBIH
    Publication Date: 2004
    detail.hit.zdb_id: 2548947-1
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  • 2
    Online Resource
    Online Resource
    Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise
    Association of Basic Medical Sciences of FBIH ; 2004
    In:  Bosnian Journal of Basic Medical Sciences Vol. 4, No. 4 ( 2004-11-20), p. 32-36
    Details
    In: Bosnian Journal of Basic Medical Sciences, Association of Basic Medical Sciences of FBIH, Vol. 4, No. 4 ( 2004-11-20), p. 32-36
    Abstract: Angiotensin converting enzyme (ACE) plays an important role in blood pressure regulation not only in the state of rest, but also during physical exercise. The aim of this study was to estimate the serum ACE activity in response to acute dynamic exercise. The study involved a group of young, healthy, male volunteers (average 22 years of age). Exercise testing was carried out on ergometer bicycle according to the protocol of individually adjusted continuous, constant workload (3 W/kg). The activity of ACE in serum was measured in venous blood, in the period of rest, in 4th, 8th and 12th minute of exercise and 1st, 3rd and 6th minute of recovery by spectrophotometric method. Marked inter-individual differences in basal serum ACE activity were determined (range 8, 31-63, 72 U/L). Serum ACE activity did not significantly vary during exercise and in the period of recovery. Systolic blood pressure changed during exercise compared to values during rest period in accordance with the applied type of dynamical exercise. Diastolic blood pressure did not vary considerably during exercise. Statistically significant correlation between mean arterial blood pressure and ACE activity in the serum was not found. The lack of increase of ACE activity in the serum, in spite of changes in blood pressure values, most likely shows the presence of alternative ACE independent pathway involved in the production of vasoactive substances that have important role in the regulation of cardiovascular system response to acutedynamic exercise.
    Type of Medium: Online Resource
    ISSN: 1840-4812 , 1512-8601
    URL: Article
    DOI: 10.17305/bjbms.2004.3357
    Language: Unknown
    Publisher: Association of Basic Medical Sciences of FBIH
    Publication Date: 2004
    detail.hit.zdb_id: 2548947-1
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  • 3
    Online Resource
    Online Resource
    Endothelin in health and disease
    Association of Basic Medical Sciences of FBIH ; 2004
    In:  Bosnian Journal of Basic Medical Sciences Vol. 4, No. 3 ( 2004-08-20), p. 31-34
    Details
    In: Bosnian Journal of Basic Medical Sciences, Association of Basic Medical Sciences of FBIH, Vol. 4, No. 3 ( 2004-08-20), p. 31-34
    Abstract: Endothelin is a recently discovered peptide composed of 21 amino acids. There are three endothelin isomers: endothelin -1 (ET-1), endothelin -2 (ET-2) and endothelin - 3 (ET-3). In humans and animals levels of ET-1, ET-2, ET-3 and big endothelin in blood range from 0,3 to 3 pg/ml. ET-1, ET-2 and ET-3 act by binding to receptors. Two main types of the receptors for endothelins exist and they are referred to as A and B type receptors. Different factors can stimulate or inhibit production of endothelin by endothelial cells. Mechanical stimulation of endothehum, thrombin, calcium ions, epinephrine, angiotensin II, vasopressin, dopamine, cytokines, growth factors stimulate the production of endothelin whereas nitric oxide, cyclic guanosine monophosphate, atrial natriuretic peptide, prostacyclin, bradykinin inhibit its production. Endothelins have different physiological roles in human body but at the same time their actions are involved in the pathogenesis of many diseases.The aim of this review was to present some of, so far, the best studied physiological roles of endothelin and to summarize evidence supporting the potential role of ET in the pathogenesis of certain diseases.
    Type of Medium: Online Resource
    ISSN: 1840-4812 , 1512-8601
    URL: Article
    DOI: 10.17305/bjbms.2004.3381
    Language: Unknown
    Publisher: Association of Basic Medical Sciences of FBIH
    Publication Date: 2004
    detail.hit.zdb_id: 2548947-1
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  • 4
    Online Resource
    Online Resource
    Combination of intraneural injection and high injection pressure leads to fascicular injury and neurologic deficits in dogs
    BMJ ; 2004
    In:  Regional Anesthesia and Pain Medicine Vol. 29, No. 5 ( 2004-09), p. 417-423
    Details
    In: Regional Anesthesia and Pain Medicine, BMJ, Vol. 29, No. 5 ( 2004-09), p. 417-423
    Type of Medium: Online Resource
    ISSN: 1098-7339
    URL: Article
    DOI: 10.1097/00115550-200409000-00005
    Language: English
    Publisher: BMJ
    Publication Date: 2004
    detail.hit.zdb_id: 2028901-7
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