In:
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, The Royal Society, Vol. 355, No. 1400 ( 2000-08-29), p. 1085-1092
Abstract:
Hepatitis C virus (HCV) infection is a major public health problem, affecting an estimated 3% of the world's population, and over 10% in some countries. Infection in most cases becomes persistent, and can lead to hepatic inflammation, fibrosis and liver failure. The T lymphocyte reponse, in particular that mediated by cytotoxic T lymphocytes (CTLs), is likely to be involved in determining the outcome of infection, although its overall role is not clear. The use of major histocompatibility complex (MHC) class I peptide tetrameric complexes (tetramers) to study antiviral CTL responses has revolutionized our approach to the study of human infection. We have used a panel of MHC class I tetramers to analyse immune responses in HCV–infected individuals at various stages of disease. We find that the CTL response against HCV is vigorous in its early phases but dwindles over time both in terms of lymphocyte number and function. A number of potential explanations for this ‘CTL failure’ are discussed.
Type of Medium:
Online Resource
ISSN:
0962-8436
,
1471-2970
DOI:
10.1098/rstb.2000.0646
Language:
English
Publisher:
The Royal Society
Publication Date:
2000
detail.hit.zdb_id:
1462620-2
SSG:
12
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