In:
Neurosurgery, Ovid Technologies (Wolters Kluwer Health), Vol. 47, No. 3 ( 2000-09-01), p. 701-710
Abstract:
The study was undertaken to measure baseline values for chemical markers in human subjects during wakefulness, anesthesia, and neurosurgery, using intracerebral microdialysis. METHODS Microdialysis catheters were inserted into normal posterior frontal cerebral cortex in nine patients who were undergoing surgery to treat benign lesions of the posterior fossa. The perfusion rate was 1.0 μl/min during anesthesia/neurosurgery and the early postoperative course and 0.3 μl/min during the later course. Bedside biochemical analyses of glucose, pyruvate, lactate, glycerol, glutamate, and urea were performed before, during, and after neurosurgery. After the bedside analyses, all samples were frozen for subsequent high-performance liquid chromatographic analyses of amino acids. RESULTS The following baseline values were obtained during wakefulness (perfusion rate, 0.3 μl/min): glucose, 1.7 ± 0.9 mmol/L; lactate, 2.9 ± 0.9 mmol/L; pyruvate, 166 ± 47 μmol/L; lactate/pyruvate ratio, 23 ± 4; glycerol, 82 ± 44 μmol/L; glutamate, 16 ± 16 mmol/L; urea, 4.4 ± 1.7 mmol/L. Marked increases in the levels of all chemical markers were observed at the beginning and end of anesthesia/surgery. CONCLUSION The study provides human baseline levels for biochemical markers that can presently be measured at the bedside during neurointensive care. In addition, some changes that occurred under varying physiological conditions are described.
Type of Medium:
Online Resource
ISSN:
0148-396X
,
1524-4040
DOI:
10.1097/00006123-200009000-00035
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2000
detail.hit.zdb_id:
1491894-8
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