In:
The British Journal of Diabetes & Vascular Disease, SAGE Publications, Vol. 1, No. 2 ( 2001-11), p. 110-114
Abstract:
Recent discoveries suggest that adipose tissue can synthesise and secrete mediators that contribute to the pathogenesis of type 2 diabetes mellitus and cardiovascular disease, leading to the concept of `adipose tissue as an endocrine organ'. These mediators include tumour necrosis factor-α, interleukin-6, adiponectin, resistin, plasminogen activator inhibitor type 1 and angiotensin II. They modify the activity of regulatory enzymes in adipocyte metabolism, alter the release of non-esterified fatty acids and affect glucose uptake. They may also have direct actions on the vascular endothelium. The diverse effects of these mediators support the notion that inflammation plays a role in metabolic and vascular disease, at least in part via adipocyte-derived cytokines.
Type of Medium:
Online Resource
ISSN:
1474-6514
,
1753-4305
DOI:
10.1177/14746514010010020801
Language:
English
Publisher:
SAGE Publications
Publication Date:
2001
detail.hit.zdb_id:
2429646-6
detail.hit.zdb_id:
3018522-1
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