In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 62, No. 6 ( 2001-06-01), p. 938-947
Kurzfassung:
Objective —To evaluate calcium balance and parathyroid
gland function in healthy horses and horses with enterocolitis and compare results of an immunochemiluminometric
assay (ICMA) with those of an immunoradiometric assay (IRMA) for determination of
serum intact parathyroid hormone (PTH) concentrations in horses. Animals —64 horses with enterocolitis and 62 healthy
horses. Procedures —Blood and urine samples were collected
for determination of serum total calcium, ionized calcium (Ca 2+ ) and magnesium (Mg 2+ ), phosphorus, BUN,
total protein, creatinine, albumin, and PTH concentrations, venous blood gases, and fractional urinary clearance
of calcium (FCa) and phosphorus (FP). Serum concentrations of PTH were measured in 40 horses by
use of both the IRMA and ICMA. Results —Most (48/64; 75%) horses with enterocolitis
had decreased serum total calcium, Ca2+, and Mg2+ concentrations and increased phosphorus concentrations,
compared with healthy horses. Serum PTH concentration was increased in most (36/51; 70.6%) horses
with hypocalcemia. In addition, FCa was significantly decreased and FP significantly increased in
horses with enterocolitis, compared with healthy horses. Results of ICMA were in agreement with results of
IRMA. Conclusions and Clinical Relevance —Enterocolitis
in horses is often associated with hypocalcemia; 79.7% of affected horses had ionized hypocalcemia.
Because FCa was low, it is unlikely that renal calcium loss was the cause of hypocalcemia. Serum PTH concentrations
varied in horses with enterocolitis and concomitant hypocalcemia. However, we believe low PTH
concentration in some hypocalcemic horses may be the result of impaired parathyroid gland function. ( Am
J Vet Res 2001;62:938–947)
Materialart:
Online-Ressource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2001.62.938
Sprache:
Unbekannt
Verlag:
American Veterinary Medical Association (AVMA)
Publikationsdatum:
2001
ZDB Id:
2056942-7
SSG:
22
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