In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 2 ( 2001-01-16), p. 585-590
Abstract:
Bipolar disorder or manic depressive illness is a major psychiatric
disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or
excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown;
however, numerous family, twin, and adoption studies have argued for a substantial genetic contribution. We have conducted a genome survey of
bipolar disorder using 443 microsatellite markers in a set of 20 families from the general North American population to identify
possible susceptibility loci. A maximum logarithm of odds score of 3.8 was obtained at D22S278 on 22q. Positive scores were found spanning a
region of nearly 32 centimorgans (cM) on 22q, with a possible secondary peak at D22S419. Six other chromosomal regions yielded suggestive
evidence for linkage: 3p21, 3q27, 5p15, 10q, 13q31-q34, and 21q22. The regions on 22q, 13q, and 10q have been implicated in studies of
schizophrenia, suggesting the possible presence of susceptibility genes common to both disorders.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.98.2.585
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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