In:
Annual Review of Biochemistry, Annual Reviews, Vol. 73, No. 1 ( 2004-06), p. 925-951
Abstract:
▪ Abstract The GoLoco motif is a 19-amino-acid sequence with guanine nucleotide dissociation inhibitor activity against G-alpha subunits of the adenylyl-cyclase-inhibitory subclass. The GoLoco motif is present as an independent element within multidomain signaling regulators, such as Loco, RGS12, RGS14, and Rap1GAP, as well as in tandem arrays in proteins, such as AGS3, G18, LGN, Pcp-2/L7, and Partner of Inscuteable (Pins/Rapsynoid). Here we discuss the biochemical mechanisms of GoLoco motif action on G-alpha subunits in light of the recent crystal structure of G-alpha-i1 bound to the RGS14 GoLoco motif. Currently, there is sparse evidence for GoLoco motif regulation of canonical G-protein–coupled receptor signaling. Rather, studies of asymmetric cell division in Drosophila and Caenorhabditis elegans, as well as mammalian mitosis, implicate GoLoco proteins, such as Pins, GPR-1/GPR-2, LGN, and RGS14, in mitotic spindle organization and force generation. We discuss potential mechanisms by which GoLoco/Gα complexes might modulate spindle dynamics.
Type of Medium:
Online Resource
ISSN:
0066-4154
,
1545-4509
DOI:
10.1146/biochem.2004.73.issue-1
DOI:
10.1146/annurev.biochem.73.011303.073756
Language:
English
Publisher:
Annual Reviews
Publication Date:
2004
detail.hit.zdb_id:
1470446-8
SSG:
12
Permalink