In:
American Journal of Medical Genetics, Wiley, Vol. 114, No. 6 ( 2002-08-08), p. 605-608
Abstract:
The human γ‐aminobutyric acid type B (GABA B ) receptor gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiologic roles. In the present study, association analyses of genetic polymorphisms of the GABA B receptor gene with schizophrenia were carried out in 102 unrelated schizophrenic patients and 100 healthy controls, using a polymerase chain reaction‐based, single‐strand conformational polymorphism analysis. Although the Ala20Val and Gly489Ser mutations were not found in our samples, we found a novel polymorphism of (AC)n dinucleotide repeats located approximately 1.6 kb upstream from the translational start site. No significant difference in allele frequencies was found between controls and patients with schizophrenia ( P = 0.0587) using the Monte Carlo method. Significant differences were found between controls and patients with continuous‐course schizophrenia ( P = 0.0019), and between controls and patients with a positive family history of psychoses ( P = 0.0015). These differences, however, were not significant after Bonferroni correction. These data did not support our hypothesis that polymorphisms of the GABA B receptor gene may confer vulnerability for schizophrenia. © 2002 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0148-7299
,
1096-8628
Language:
English
Publisher:
Wiley
Publication Date:
2002
detail.hit.zdb_id:
2143866-3
detail.hit.zdb_id:
2143867-5
detail.hit.zdb_id:
1493479-6
detail.hit.zdb_id:
2205916-7
SSG:
12
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