In:
Microsurgery, Wiley, Vol. 21, No. 4 ( 2001-01), p. 173-178
Abstract:
An investigation of the functional and histological changes was done after en‐bloc kidney‐pancreaticoduodenal transplantation (kpdt) in the diabetes‐induced, renal insufficient Lewis rats. For donor preparation, an end‐to‐side portocaval shunt was performed, and the aortic, vena caval segments, and ureter‐bladder patch were obtained. They were anastomosed microsurgically to recipient's aorta, vena cava, and bladder in end‐to‐side fashion. Of 15 diabetes‐induced kpdt rats, 14 survived. Two of the 14 surviving rats showed ischemic necrosis. The remaining 12 transplants showed well‐preserved glomeruli and Langerhans islets for 5 months postoperatively. Biochemical data comparing diabetic and sham‐operated rats (six rats each), six diabetic controls, and 12 kpdt rats showed no significant statistical difference at said observation period. The diabetes‐induced kpdt rats showed improvement of following biochemical data: within 1 week postoperatively, the glucose level fell from 300 to 115 mg/dL; BUN level from 〉 20 to 〈 20 mg/dL; the creatinine level from 1.5 to 〈 1.2 mg/dL. The insulin level returned to normal, 1.1 ng/mL, in 2 weeks. The results demonstrate that the kpdt model is an effective and successful operative technique in diabetic rats and may provide effective therapeutic methods for diabetes‐induced renal insufficiency. © 2001 Wiley‐Liss, Inc. MICROSURGERY 21:173–178 2001
Type of Medium:
Online Resource
ISSN:
0738-1085
,
1098-2752
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
1475571-3
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