In:
Journal of Biological Rhythms, SAGE Publications, Vol. 17, No. 6 ( 2002-12), p. 512-519
Abstract:
It is known that retinally degenerate C57BL/6J ( rd/rd) mice have unattenuated circadian photosensitivity. However, the authors have previously found that CBA/J ( rd/rd) mice that carry the same rd mutation have attenuated circadian photosensitivity compared to normal CBA/N (+/+) mice. In the present study, a quantitative trait locus (QTL) analysis using C57BL/6J ( rd/rd) and CBA/J ( rd/rd) mice was conducted in order to identify the genes affecting circadian photosensitivity of the rd mice. As a result, several putative QTLs on three separate chromosomes (8, 12, 17) were detected, which indicates that circadian photosensitivity in rd mice is altered by multiple genes. Identification of these genes may provide new insights into the understanding of regulation of circadian photoentrainment and sleep-wake disorders.
Type of Medium:
Online Resource
ISSN:
0748-7304
,
1552-4531
DOI:
10.1177/0748730402238233
Language:
English
Publisher:
SAGE Publications
Publication Date:
2002
detail.hit.zdb_id:
2018064-0
SSG:
12
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