In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1031, No. 1 ( 2004-12), p. 60-73
Abstract:
A bstract : Limited information is available on factors that can influence vitamin E bioavailability. In several studies we have investigated the influence of dietary, biochemical, and genetic factors on vitamin E biokinetics. In these studies, subjects ingested a capsule containing 150 mg deuterated RRR ‐α‐tocopheryl acetate, blood was taken up to 48 hr, and tocopherols were analyzed by liquid chromatography and mass spectroscopy. There was significantly greater plasma‐labeled α‐tocopherol concentrations when the capsule was consumed with a high‐fat meal (17.5 g) versus a low‐fat meal (2.7 g), and there was also a difference between a high‐fat toast and butter and a cereal with full‐fat milk meal (both 17.5 g fat), indicating that both the amount of fat and food matrix is important for vitamin E absorption. Dyslipidemic subjects displayed a reduced plasma uptake of newly absorbed α‐tocopherol, and differences were also apparent in individual lipoproteins. A decreased uptake of labeled α‐tocopherol was also observed in erythrocytes, platelets, and lymphocytes of dyslipidemics. Following vitamin E supplementation (400 mg/day, 4 weeks), the uptake of newly absorbed α‐tocopherol was decreased, presumably because of saturation of α‐tocopherol transfer protein. We also found that apoE3 subjects displayed a considerably reduced uptake of newly absorbed labeled α‐tocopherol compared to apoE4 subjects, which may be a consequence of the reduced low‐density lipoprotein catabolic rate in these subjects. Taken together, these data show that several physiological factors influence the uptake of newly absorbed α‐tocopherol, and that this is an important consideration in the design of future vitamin E supplementation studies.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1196/annals.1331.006
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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