In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 65, No. 6 ( 2004-06-01), p. 847-853
Abstract:
Objective —To evaluate the tensile strength, elongation,
and degradation of 4 monofilament absorbable suture materials that undergo degradation by hydrolysis
in specimens of canine urine with various physical characteristics. Sample Population —4 monofilament absorbable
sutures (polydioxanone, poliglecaprone 25, polyglyconate, and glycomer 631). Procedure —Voided urine was collected from 6
healthy dogs, pooled, filter-sterilized, and prepared to provide 5 media: sterile neutral (pH, 7.0), sterile acidic
(pH, 6.2), sterile basic (pH, 8.8), Escherichia coli -inoculated,
and Proteus mirabilis -inoculated urine. Ten
strands of each suture material were immersed in each of the media for 0 to 28 days. Tensile strength
and elongation of each suture material were evaluated by use of a texture analyzer on days 0, 1, 3, 7, 10,
14, 21, and 28. Results —Reduction in tensile strength was detected
for all materials in all urine specimens over time. Polyglyconate and polydioxanone had superior tensile
strengths in sterile neutral and E coli -inoculated urine,
and polydioxanone retained the greatest tensile strength throughout the study period. All suture materials
disintegrated before day 7 in P mirabilis -inoculated
urine. Conclusions and Clinical Relevance —Polydioxanone, polyglyconate, and glycomer 631 may
be acceptable for urinary bladder closure in the presence of sterile neutral and E coli -contaminated urine.
Tensile strength of poliglecaprone 25 in urine may be unacceptable by the critical healing time for bladder
tissue (14 to 21 days). During bladder surgery, exposure of suture material that degrades via hydrolysis to
urine containing Proteus spp should be minimized. Am J Vet Res (2004;65:847–853)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2004.65.847
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2004
detail.hit.zdb_id:
2056942-7
SSG:
22
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