In:
Annals of Neurology, Wiley, Vol. 54, No. 4 ( 2003-10), p. 530-533
Abstract:
We found voltage‐gated potassium channel (VGKC) antibodies in 4 of 15 patients with limbic encephalitis (LE). Two patients with idiopathic LE had high VGKC antibody levels ( 〉 800pM; controls 〈 100pM), that fell in parallel with a clinical response to immunotherapy. Two patients with lower VGKC antibodies (170pM, 300pM) had lung cancer (radiological evidence only in one) and the LE improved with immunotherapy in one. The other 11 patients without VGKC antibodies had paraneoplastic LE and eight onconeural antibodies (Hu in 6; Ma2 in 2). VGKC antibodies do not unambiguously discriminate between idiopathic or paraneoplastic LE but probably indicate a good response to immunotherapy. Ann Neurol 2003;54:530‐533
Type of Medium:
Online Resource
ISSN:
0364-5134
,
1531-8249
Language:
English
Publisher:
Wiley
Publication Date:
2003
detail.hit.zdb_id:
2037912-2
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