In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 26 ( 2001-12-18), p. 15270-15275
Abstract:
Hepatitis E virus recombinant genomes transcribed in
vitro from two cDNA clones differing by two nucleotides were
infectious for chimpanzees. However, one cDNA clone encoded a virus that was attenuated for chimpanzees and unable to infect rhesus
monkeys. The second cDNA clone encoded a virus that infected both chimpanzees and rhesus monkeys and caused acute hepatitis in both. One
mutation differentiating the two clones identified a cis-reactive element that appeared to overlap the 3′ end of the capsid gene and part
of the 3′ noncoding region. Capping of the RNA transcripts was essential for infectivity.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.251555098
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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