In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 21, No. 17 ( 2003-09-01), p. 3207-3213
Abstract:
Purpose: To compare the survival benefit obtained with cisplatin plus gemcitabine, a cisplatin-based triplet, and nonplatinum sequential doublets in advanced non–small-cell lung cancer (NSCLC). Patients and Methods: Stage IIIB to IV NSCLC patients were randomly assigned to receive cisplatin 100 mg/m 2 day 1 plus gemcitabine 1,250 mg/m 2 days 1 and 8, every 3 weeks for six cycles (CG); cisplatin 100 mg/m 2 day 1 plus gemcitabine 1,000 mg/m 2 and vinorelbine 25 mg/m 2 days 1 and 8, every 3 weeks for six cycles (CGV); or gemcitabine 1,000 mg/m 2 plus vinorelbine 30 mg/m 2 days 1 and 8, every 3 weeks for three cycles, followed by vinorelbine 30 mg/m 2 days 1 and 8 plus ifosfamide 3 g/m 2 day 1, every 3 weeks for three cycles (GV–VI). Results: Five hundred fifty-seven patients were assigned to treatment (182 CG, 188 CGV, 187 GV–VI). Response rates were significantly inferior for the nonplatinum sequential doublet (CG, 42%; CGV, 41%; GV–VI, 27%; CG v GV–VI, P = .003). No differences in median survival or time to progression were observed. Toxicity was higher for the triplet: grade 3 to 4 neutropenia (GC, 32%; CGV, 57%; GV–VI, 27%; P 〈 .05); neutropenic fever (CG, 4%; CGV, 19%; GV–VI, 5%; P 〈 .0001); grade 3 to 4 thrombocytopenia (CG, 19%; CGV, 23%; GV–VI, 3%; P = .0001); and grade 3 to 4 emesis (GC, 22%; GCV, 32%; GV–VI, 6%; P 〈 .0001). Conclusion: On the basis of these results, CG remains a standard regimen for first-line treatment of advanced NSCLC.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/JCO.2003.12.038
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2003
detail.hit.zdb_id:
2005181-5
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