In:
Advanced Synthesis & Catalysis, Wiley, Vol. 346, No. 9-10 ( 2004-08), p. 1101-1105
Abstract:
A novel series of ( S )‐ N ‐arenesulfonyl‐2‐aminomethylpyrrolidines were prepared in high overall yield starting from N ‐Boc‐ L ‐proline. The mono‐sulfonyldiamines were evaluated as organocatalysts in the asymmetric α‐amination of propanal using diethyl azadicarboxylate (DEAD) as the amine source. The initially formed α‐aminated aldehyde was reduced in situ to the corresponding N ‐aminooxazolidinone, which was obtained in moderate to high yield in up to 87% ee.
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.v346:9/10
DOI:
10.1002/adsc.200404098
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4
Permalink