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  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 2001
    In:  American Journal of Kidney Diseases Vol. 38, No. 4 ( 2001-10), p. 876-880
    In: American Journal of Kidney Diseases, Elsevier BV, Vol. 38, No. 4 ( 2001-10), p. 876-880
    Type of Medium: Online Resource
    ISSN: 0272-6386
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2001
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  • 2
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2002
    In:  Stroke Vol. 33, No. 11 ( 2002-11), p. 2670-2674
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 33, No. 11 ( 2002-11), p. 2670-2674
    Abstract: Background and Purpose— Accurate information about hospital resource utilization is necessary for management of healthcare service. The purpose of this study was to determine the demographic and clinical predictors of length of hospital stay (LOS) of acute care hospitalization for first-ever ischemic stroke patients. Methods— A group of 330 patients who suffered from first-ever ischemic stroke and were consecutively admitted to a medical center in southern Taiwan were followed prospectively. Because our intention was to identify the major predictors of LOS from the information available at admission, we evaluated only those factors that could be assessed at the time of admission. Univariate analysis and multiple regression analysis were used to identify the main predictors of LOS. Results— The median LOS was 7 days (mean, 11 days; range, 1 to 122 days). Among the prespecified demographic and clinical characteristics, National Institutes of Health Stroke Scale (NIHSS) score at admission, the quadratic term of the initial NIHSS score, modified Barthel Index score at admission, small-vessel occlusion stroke, sex, and smoking were the main explanatory factors for LOS. In particular, for each 1-point increase in the total score of NIHSS, LOS increased approximately 1 day for patients with mild or moderate (score 0 to 15 points) neurological impairments, while LOS decreased approximately 1 day for patients with severe (score 〉 15 points) neurological impairments. Conclusions— The severity of stroke, as rated by the total score on NIHSS, is an important factor that influences LOS after acute stroke hospitalization.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2002
    detail.hit.zdb_id: 1467823-8
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  • 3
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 20, No. 11 ( 2004-11), p. 525-532
    Abstract: Enteroviruses are environmental triggers in the pathogenesis of type 1 diabetes mellitus (DM). A sequence of six identical amino acids (PEVKEK) is shared by the 2C protein of Coxsackie virus B and the glutamic acid decarboxylase (GAD) molecules. Between 1995 and 2002, we investigated 22 Coxsackie virus B5 (CVB5) isolates from southern Taiwan. Four of these isolates were obtained from four new‐onset type 1 DM patients with diabetic ketoacidosis. We compared a 300 nucleotide sequence in the 2C protein gene (p2C) in 24 CVB5 isolates (4 diabetogenic, 18 non‐diabetogenic and 2 prototype). We found 0.3‐10% nucleotide differences. In the four isolates from type 1 DM patients, there was only 2.4‐3.4% nucleotide difference, and there was only 1.7‐7.1% nucleotide difference between type 1 DM isolates and non‐diabetogenic isolates. Comparison of the nucleotide sequence between prototype virus and 22 CVB5 isolates revealed 18.4‐24.1% difference. Twenty‐one CVB5 isolates from type 1 DM and non‐type 1 DM patients contained the PEVKEK sequence, as shown by the p2C nucleotide sequence. Our data showed that the viral p2C sequence with homology with GAD is highly conserved in CVB5 isolates. There was no difference between diabetogenic and non‐diabetogenic CVB5 isolates. All four type 1 DM patients had at least one of the genetic susceptibility alleles HLA‐DR, DQA1, DQB1. Other genetic and autoimmune factors such as HLA genetic susceptibility and GAD may also play important roles in the pathogenesis in type 1 DM.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2202782-8
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