In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 103, No. 17 ( 2001-05), p. 2130-2132
Abstract:
Background —Vessel remodeling is an important mechanism of late lumen loss after nonstent coronary interventions. However, its impact on in-stent restenosis has not been systematically investigated. Methods and Results —Serial volumetric intravascular ultrasound analyses (poststent and follow-up) were performed in 55 lesions treated with a balloon-expandable stent (ACS MultiLink) using standard stent deployment techniques. The vessel volume (VV), lumen volume (LV), and volume bordered by the stent (SV) were measured using Simpson’s method. The volume of plaque and neointima outside the stent (peri-stent volume, PSV) and volume of neointima within the stent (intrastent volume) were also measured. The change of each parameter during the follow-up period (follow-up minus poststent) was calculated and then divided by SV to normalize these values (designated as percent change [%Δ]). As expected, %ΔPSV directly correlated with %ΔVV ( P 〈 0.0001, r =0.935), with no significant ΔSV. A highly significant inverse correlation was seen between %ΔPSV and the percent change of intrastent volume ( P 〈 0.0001, r =0.517). Consequently, %ΔLV significantly correlated with peri-stent remodeling, as measured by %ΔVV ( P 〈 0.0001, r =0.602). Conclusion —Positive remodeling of the vessel exterior to a coronary stent occurs to a variable degree after stent implantation. There is a distinct trade-off between positive remodeling and in-stent hyperplasia: in segments in which the degree of peri-stent remodeling is less, intrastent neointimal proliferation is greater and accompanied by more significant late lumen loss.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/01.CIR.103.17.2130
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2001
detail.hit.zdb_id:
1466401-X
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