In:
Learning & Memory, Cold Spring Harbor Laboratory, Vol. 10, No. 5 ( 2003-09), p. 410-419
Kurzfassung:
The 5-HT 3 receptor for serotonin is expressed within limbic
structures and is known to modulate neurotransmitter release, suggesting that this receptor may influence learning and memory. Perturbations in serotonergic
neurotransmission lead to changes in the ability to attend, learn, and remember. To examine the role of 5-HT 3 receptors in learning,
memory, and attention, 5-HT 3 receptor overexpressing
(5-HT 3 -OE) transgenic mice and their wild-type littermates (WT)
were tested in Pavlovian contextual and cued fear conditioning, fear extinction, and latent inhibition (LI) paradigms. Prepulse inhibition (PPI)
was assessed to reveal changes in sensorimotor gating. Additionally, anxious behaviors, shock sensitivity, and reactions to novel stimuli were evaluated.
5-HT 3 -OE mice displayed enhanced contextual conditioning, whereas
cued conditioning remained the same as that of WT mice. 5-HT 3 -OE
mice did not differ from WT in extinction rates to either the context or cue. LI was enhanced for 5-HT 3 -OE mice compared to WT. PPI remained
unchanged. No differences in sensitivity to footshock or startle were found. However, 5-HT 3 -OE mice demonstrated heightened exploratory behavior
in response to novel environmental stimuli and decreased anxiety as measured in the elevated plus-maze. Results indicate that overexpression of the
5-HT 3 receptor in mouse forebrain results in enhanced
hippocampal-dependent learning and attention. Enhanced inspective behavior in response to novelty may contribute to the observed improvements in learning,
memory, and attention due to 5-HT 3 receptor overexpression.
Materialart:
Online-Ressource
ISSN:
1072-0502
,
1549-5485
Sprache:
Englisch
Verlag:
Cold Spring Harbor Laboratory
Publikationsdatum:
2003
ZDB Id:
2022057-1
SSG:
12
SSG:
5,2
Permalink