In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 8 ( 2001-04-10), p. 4658-4663
Abstract:
The 1,852,442-bp sequence of an M1 strain of Streptococcus
pyogenes , a Gram-positive pathogen, has been determined and
contains 1,752 predicted protein-encoding genes. Approximately one-third of these genes have no identifiable function, with the
remainder falling into previously characterized categories of known microbial function. Consistent with the observation that S.
pyogenes is responsible for a wider variety of human disease
than any other bacterial species, more than 40 putative virulence-associated genes have been identified. Additional genes have
been identified that encode proteins likely associated with microbial “molecular mimicry” of host characteristics and involved in
rheumatic fever or acute glomerulonephritis. The complete or partial sequence of four different bacteriophage genomes is also present, with
each containing genes for one or more previously undiscovered superantigen-like proteins. These prophage-associated genes encode at
least six potential virulence factors, emphasizing the importance of bacteriophages in horizontal gene transfer and a possible mechanism for
generating new strains with increased pathogenic potential.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.071559398
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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