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  • 1
    In: The American Journal of Sports Medicine, SAGE Publications, Vol. 45, No. 6 ( 2017-05), p. 1440-1446
    Abstract: The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore, eccentric exercise seems to improve the mechanical quality of the tendon. Hypothesis: A combination of PRP injection and eccentric training might be more effective than either treatment alone. Study Design: Controlled laboratory study. Methods: Adult male rats were anesthetized, an incision was performed in the middle of their left patellar tendon and an injection of physiological fluid (PF) or homologous PRP was randomly made at the lesion level. The rats were then divided into 2 groups: the eccentric group, undergoing eccentric training 3 times a week, and the untrained group, without any training. Thus, 4 groups were compared. After 5 weeks, the tendons were removed and their ultimate tensile strength and energy were measured. Tendons were frozen for proteomic analyses when all biomechanical tests were completed. Statistical analysis was performed with linear mixed effect models. Results: No significant difference was found between the treatments using PF injection or PRP injection alone. However, the value of the ultimate tensile force at rupture was increased by 4.5 N (108% of control, P = .006) when eccentric training was performed. An intragroup analysis revealed that eccentric training significantly improved the ultimate force values for the PRP group. Proteomic analysis revealed that eccentric training led to an increase in abundance of several cytoskeletal proteins in the PF group, while a decrease in abundance of enzymes of the glycolytic pathway occurred in the PRP-treated groups, indicating that this treatment might redirect the exercise-driven metabolic plasticity of the tendon. Conclusion: Eccentric training altered the metabolic plasticity of tendon and led to an improvement of injured tendon resistance regardless of the treatment injected (PF or PRP). Clinical Relevance: This study demonstrates the necessity of eccentric rehabilitation and training in cases of tendon lesion regardless of the treatment carried out.
    Type of Medium: Online Resource
    ISSN: 0363-5465 , 1552-3365
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2063945-4
    SSG: 31
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  • 2
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 40, No. 3 ( 2020-03), p. 667-677
    Abstract: In large vessel occlusion (LVO) stroke, it is unclear whether severity of ischemia is involved in early post-thrombolysis recanalization over and above thrombus site and length. Here we assessed the relationships between perfusion parameters and early recanalization following intravenous thrombolysis administration in LVO patients. From a multicenter registry, we identified 218 thrombolysed LVO patients referred for thrombectomy with both (i) pre-thrombolysis MRI, including diffusion-weighted imaging (DWI), T2*-imaging, MR-angiography and dynamic susceptibility-contrast perfusion-weighted imaging (PWI); and (ii) evaluation of recanalization on first angiographic run or non-invasive imaging ≤ 3 h from thrombolysis start. Infarct core volume on DWI, PWI-DWI mismatch volume and hypoperfusion intensity ratio (HIR; defined as Tmax ≥ 10 s volume/ Tmax ≥ 6 s volume, low HIR indicating milder hypoperfusion) were determined using a commercially available software. Early recanalization occurred in 34 (16%) patients, and multivariable analysis was associated with lower HIR ( P = 0.006), shorter thrombus on T2*-imaging ( P  〈  0.001) and more distal occlusion ( P = 0.006). However, the relationship between HIR and early recanalization was robust only for thrombus length 〈 14 mm. In summary, the present study disclosed an association between lower HIR and early post-thrombolysis recanalization. Early post-thrombolysis recanalization is therefore determined not only by thrombus site and length but also by severity of ischemia.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2039456-1
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  Clinical and Applied Thrombosis/Hemostasis Vol. 21, No. 4 ( 2015-05), p. 319-324
    In: Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 21, No. 4 ( 2015-05), p. 319-324
    Abstract: Using parenteral anticoagulants in compliance with their summaries of product characteristics (SPCs) and consensus guidelines is associated with decreased rates of adverse drug reactions. The objectives were to assess compliance of parenteral anticoagulants use with SPCs and 4 consensus guidelines in outpatients of general practice. A descriptive cross-sectional study was conducted among 112 teaching general practitioners’ offices, from May to October 2011. Among the 332 adult outpatients consecutively included, 108 (32.5%) had a parenteral anticoagulant therapy complying with SPCs for both indication and regimen. The rate of compliance increased when considering consensus guidelines (159 patients, 47.9%). Rate of adverse events was 5.4%, including 0.6% of serious adverse events. This study showed that the use of parenteral anticoagulants complies with indications and regimens of SPCs in only 1 of the 3 outpatients. Further studies should be conducted in primary care to explore reasons for such low compliance rates.
    Type of Medium: Online Resource
    ISSN: 1076-0296 , 1938-2723
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2230591-9
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2020
    In:  International Journal of Social Psychiatry Vol. 66, No. 7 ( 2020-11), p. 682-692
    In: International Journal of Social Psychiatry, SAGE Publications, Vol. 66, No. 7 ( 2020-11), p. 682-692
    Abstract: For psychiatric service users, the personal social network offers resources such as behavioural guidance, social support, and coherence of care delivery. So far, most research on the subject has assessed the availability of these resources using size and composition measures. However, the availability of network resources also depends on the cohesion of the relationships between network members, a topic that is rarely addressed in the literature. Aims: In this article, we aim to describe the cohesion of psychiatric service users’ networks. Method: We carried out a personal network survey and collected data on the social networks of 380 service users recruited in outpatient and inpatient services in Belgium. We used an ego-network mapping technique. The data were analysed using several structural metrics describing size, composition, and cohesion. We carried out analysis of variance (ANOVA) in relation to residential status, level of education, psychiatric history, and psychosocial functioning and analysed three cohesion indicators (density, fragmentation, and centralisation) with regression analyses. Results: Personal social networks were small and not very cohesive. Most were composed of a dense subgroup as well as several isolated network members. The analyses revealed that highly educated psychiatric service users had more fragmented networks, while users living in independent accommodation had less dense networks. Density and fragmentation were not associated with the severity of psychosocial functioning, whereas centralisation was. Conclusions: The low level of cohesion may indicate that service users aim to access multiple and diverse social resources and that better-off service users are more successful at doing so. On the whole, however, these personal social networks were fragile, because they contained a high number of isolated network members. Finally, it could be beneficial for professionals to pay special attention to the central persons within the networks of psychiatric service users.
    Type of Medium: Online Resource
    ISSN: 0020-7640 , 1741-2854
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2066492-8
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  • 5
    In: Vascular Medicine, SAGE Publications, Vol. 14, No. 4 ( 2009-11), p. 331-338
    Abstract: Abstract Proximal claudication remains a difficult diagnosis. The ankle to brachial index may be insensitive in the case of isolated hypogastric lesions. Penile pressure represents an alternative method for proximal arteries. Surprisingly, the accuracy of penile pressure measurement in detecting lesions on the arteries supplying pelvic circulation in patients suffering claudication has rarely been studied. We aimed to evaluate the diagnostic accuracy of the penile brachial index 〈 0.60 (penile over brachial systolic pressure ratio) to non-invasively investigate arteriographic lesions on arteries supplying the hypogastric circulation in 88 male patients referred for Fontaine stage II. The receiver operating characteristic (ROC) curve was used to define the diagnostic performance of the penile brachial index and search for a specific cut-off point in this population. Accuracy was 69.3% (95% confidence interval: 58.6–78.7) for the detection of an arterial stenosis or occlusion on at least one side. The penile brachial index ≤ 0.45 was 74% sensitive and 68% specific to discriminate the 19 patients with bilateral arterial occlusion from the other 66 patients. In conclusion, the penile brachial index is relatively insensitive for the detection of proximal abnormal blood flow impairment except in the case of bilateral occlusion of arteries supplying the hypogastric circulation in patients with claudication. A normal penile pressure is probably not efficient enough to rule out the presence of lesions on the arteries towards the hypogastric circulation in patients with arterial claudication.
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2027562-6
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  • 6
    In: Vascular Medicine, SAGE Publications, Vol. 9, No. 4 ( 2004-11), p. 261-265
    Abstract: Among the last 250 claudicants referred to the laboratory for transcutaneous oxygen pressure recording at exercise, we analyzed the symptoms reported by the 36 patients who showed isolated proximal (without distal) ischemia. Among the symptomatic proximal sites cited by these patients, the hip and thigh represent 60%, whereas the buttock is cited in fewer than 25% of cases. Buttock symptoms are reported in only 31% of symptomatic patients. ‘Buttock’ claudication is probably not the dominant symptom in isolated proximal vascular ischemia. Assessing proximal lower limb ischemia through the sole detection of ‘buttock pain’ could contribute to the underestimation of proximal vascular ischemia.
    Type of Medium: Online Resource
    ISSN: 1358-863X , 1477-0377
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2004
    detail.hit.zdb_id: 2027562-6
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 1998
    In:  Asian Cardiovascular and Thoracic Annals Vol. 6, No. 1 ( 1998-03), p. 78-79
    In: Asian Cardiovascular and Thoracic Annals, SAGE Publications, Vol. 6, No. 1 ( 1998-03), p. 78-79
    Type of Medium: Online Resource
    ISSN: 0218-4923 , 1816-5370
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1998
    detail.hit.zdb_id: 2044527-1
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  • 8
    Online Resource
    Online Resource
    SAGE Publications ; 2012
    In:  Journal of Telemedicine and Telecare Vol. 18, No. 4 ( 2012-06), p. 189-192
    In: Journal of Telemedicine and Telecare, SAGE Publications, Vol. 18, No. 4 ( 2012-06), p. 189-192
    Abstract: We assessed the satisfaction of onboard caregivers with the maritime telehealth service provided by the Centre de Consultations Médicales Maritimes (CCMM). We conducted a survey of captains and caregivers by email. Of the 385 surveys sent out, 165 (43%) were completed. Eighty four percent of responders ( n = 110) thought that waiting time was satisfactory or very satisfactory, and 97% ( n = 128) were satisfied or very satisfied with their relationship with the remote physician. Thirty eight per cent of participants ( n = 50) considered that the physician understood the medical problem very well; understanding was good in 58% of cases ( n = 76) and bad in only 4% of cases ( n = 5). Sixty two per cent of participants ( n = 83) sent pictures before consultation. The respondents were also satisfied with the telephone advice overall, the competence of the physicians providing the advice, the length of time spent waiting, the verbal prescription and the medical advice given. Onboard caregivers were generally well satisfied with the maritime teleconsultations and the advice provided by the CCMM physicians.
    Type of Medium: Online Resource
    ISSN: 1357-633X , 1758-1109
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2007700-2
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  • 9
    In: The Holocene, SAGE Publications, Vol. 28, No. 8 ( 2018-08), p. 1313-1324
    Abstract: The nutrient-poor grasslands of Western Europe are of major conservation concern because land use changes threaten their high biodiversity. Studies assessing their characteristics show that their past and on-going dynamics are strongly related to human activities. Yet, the initial development patterns of this specific ecosystem remain unclear. Here, we examine findings from previous paleoecological investigations performed at local level on European grassland areas ranging from several hundred square meters to several square kilometers. Comparing data from these locally relevant studies at a regional scale, we investigate these grasslands’ spatiotemporal patterns of origin and long-term dynamics. The study is based on taxonomic identification and radiocarbon AMS dating of charcoal pieces from soil/soil sediment archives of nutrient-poor grasslands in Mediterranean and temperate Western Europe (La Crau plain, Mont Lozère, Grands Causses, Vosges Mountains, Franconian Alb, and Upper-Normandy region). We address the following questions: (1) What are the key determinants of the establishment of these nutrient-poor grasslands? (2) What temporal synchronicities might there be? and (3) What is the spatial scale of these grasslands’ past dynamics? The nutrient-poor grasslands in temperate Western Europe are found to result from the first anthropogenic woodland clearings during the late Neolithic, revealed by fire events in mesophilious mature forests. In contrast, the sites with Mediterranean affinities appear to have developed at earlier plant successional stages (pine forest, matorral), established before the first human impacts in the same period. However, no general pattern of establishment and dynamics of the nutrient-poor grasslands could be identified. Local mechanisms appear to be the key determinants of the dynamics of these ecosystems. Nevertheless, this paleoecological synthesis provides insights into past climate or human impacts on present-day vegetation.
    Type of Medium: Online Resource
    ISSN: 0959-6836 , 1477-0911
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2027956-5
    SSG: 14
    SSG: 3,4
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2000
    In:  Journal of Endotoxin Research Vol. 6, No. 6 ( 2000-12), p. 463-469
    In: Journal of Endotoxin Research, SAGE Publications, Vol. 6, No. 6 ( 2000-12), p. 463-469
    Abstract: Our insight of the sepsis response has evolved to encompass not only the pro-inflammatory but also an anti-inflammatory reaction following infection. Clinical trials have been designed to target either bacterial products, endotoxin in particular, or mediators involved in the sepsis response, but until recently the majority of them have given unfavorable results. In this article, we provide a scope of clinical trials that have been done in immunomodulation during sepsis whether or not they provide positive results. We will also discuss some of the reasons why those studies have been disappointing. Current and future trials with a better assessment of inflammatory status of patients and better-defined outcomes such as organ dysfunction are now underway.
    Type of Medium: Online Resource
    ISSN: 0968-0519
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
    detail.hit.zdb_id: 2381250-3
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