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  • 1
    Online Resource
    Online Resource
    Guidelines of the International Headache Society for Controlled Clinical Trials in Cluster Headache
    SAGE Publications ; 2022
    In:  Cephalalgia Vol. 42, No. 14 ( 2022-12), p. 1450-1466
    Details
    In: Cephalalgia, SAGE Publications, Vol. 42, No. 14 ( 2022-12), p. 1450-1466
    Abstract: In 1995, a committee of the International Headache Society developed and published the first edition of the Guidelines for Controlled Trials of Drugs in Cluster Headache. These have not been revised. With the emergence of new medications, neuromodulation devices and trial designs, an updated version of the International Headache Society Guidelines for Controlled Clinical Trials in Cluster Headache is warranted. Given the scarcity of evidence-based data for cluster headache therapies, the update is largely consensus-based, but takes into account lessons learned from recent trials and demands by patients. It is intended to apply to both drug and neuromodulation treatments, with specific proposals for the latter when needed. The primary objective is to propose a template for designing high quality, state-of-the-art, controlled clinical trials of acute and preventive treatments in episodic and chronic cluster headache. The recommendations should not be regarded as dogma and alternative solutions to particular methodological problems should be explored in the future and scientifically validated.
    Type of Medium: Online Resource
    ISSN: 0333-1024 , 1468-2982
    URL: Article
    DOI: 10.1177/03331024221120266
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2019999-5
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  • 2
    Online Resource
    Online Resource
    Relationship Between Anti-DFS70 Autoantibodies and Oxidative Stress
    SAGE Publications ; 2022
    In:  Biomarker Insights Vol. 17 ( 2022-01), p. 117727192110667-
    Details
    In: Biomarker Insights, SAGE Publications, Vol. 17 ( 2022-01), p. 117727192110667-
    Abstract: The anti-DFS70 autoantibodies are one of the most commonly and widely described agent of unknown clinical significance, frequently detected in healthy individuals. It is not known whether the DFS70 autoantibodies are protective or pathogenic. One of the factors suspected of inducing the formation of anti-DFS70 antibodies is increased oxidative stress. We evaluated the coexistence of anti-DFS70 antibodies with selected markers of oxidative stress and investigated whether these antibodies could be considered as indirect markers of oxidative stress. Methods: The intensity of oxidative stress was measured in all samples via indices of free-radical damage to lipids and proteins such as total oxidant status (TOS), concentrations of lipid hydroperoxides (LPH), lipofuscin (LPS), and malondialdehyde (MDA). The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid concentration (UA), were also measured, as well as the activity of superoxide dismutase (SOD). Based on TOS and TAS values, the oxidative stress index (OSI) was calculated. All samples were also tested with indirect immunofluorescence assay (IFA) and 357 samples were selected for direct monospecific anti DFS70 enzyme-linked immunosorbent assay (ELISA) testing. Results: The anti-DFS70 antibodies were confirmed by ELISA test in 21.29% of samples. Compared with anti-DFS70 negative samples we observed 23% lower concentration of LPH ( P = .038) and 11% lower concentration of UA ( P = .005). TOS was 20% lower ( P = .014). The activity of SOD was up to 5% higher ( P = .037). The Pearson correlation showed weak negative correlation for LPH, UA, and TOS and a weak positive correlation for SOD activity. Conclusion: In samples positive for the anti-DFS70 antibody a decreased level of oxidative stress was observed, especially in the case of samples with a high antibody titer. Anti-DFS70 antibodies can be considered as an indirect marker of reduced oxidative stress or a marker indicating the recent intensification of antioxidant processes.
    Type of Medium: Online Resource
    ISSN: 1177-2719 , 1177-2719
    URL: Article
    DOI: 10.1177/11772719211066791
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2256754-9
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  • 3
    Online Resource
    Online Resource
    “I miss the care even though I know it’s just a machine”: An explorative study of the relationship between an Internet-based smoking cessation intervention and its participants
    SAGE Publications ; 2013
    In:  Health Informatics Journal Vol. 19, No. 3 ( 2013-09), p. 233-243
    Details
    In: Health Informatics Journal, SAGE Publications, Vol. 19, No. 3 ( 2013-09), p. 233-243
    Abstract: This study aimed to investigate how users perceive the different elements of an internet based smoking cessation intervention and to see if the program meet needs and expectations of people in a smoking cessation process. Nine semi-structured interviews were conducted in February 2010. Participants were recruited via the homepage of the smoking cessation program Dit Digitale Stopprogram (Your Digital Quit Program) operated by the Danish Cancer Society. The main result was that participants established a relationship to the program which influenced their smoking cessation process. Participants perceived the program as caring and found it supportive. However, the program also created feelings of frustration, disappointment and anger. Some participants in the last phase of cessation experienced text messages from the program as smoking cues. The study concluded that individual interpretations of the different elements in an Internet-based smoking cessation intervention can have both positive and negative impact on the smoking cessation process of participants.
    Type of Medium: Online Resource
    ISSN: 1460-4582 , 1741-2811
    URL: Article
    DOI: 10.1177/1460458212470572
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2070802-6
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  • 4
    Online Resource
    Online Resource
    The Systematic Development of an Internet-Based Smoking Cessation Intervention for Adults
    SAGE Publications ; 2016
    In:  Health Promotion Practice Vol. 17, No. 4 ( 2016-07), p. 490-500
    Details
    In: Health Promotion Practice, SAGE Publications, Vol. 17, No. 4 ( 2016-07), p. 490-500
    Abstract: Objectives. The objective of this project was to determine whether intervention mapping is a suitable strategy for developing an Internet- and text message–based smoking cessation intervention. Method. We used the Intervention Mapping framework for planning health promotion programs. After a needs assessment, we identified important changeable determinants of cessation behavior, specified objectives for the intervention, selected theoretical methods for meeting our objectives, and operationalized change methods into practical intervention strategies. Results. We found that “social cognitive theory,” the “transtheoretical model/stages of change,” “self-regulation theory,” and “appreciative inquiry” were relevant theories for smoking cessation interventions. From these theories, we selected modeling/behavioral journalism, feedback, planning coping responses/if-then statements, gain frame/positive imaging, consciousness-raising, helping relationships, stimulus control, and goal-setting as suitable methods for an Internet- and text-based adult smoking cessation program. Furthermore, we identified computer tailoring as a useful strategy for adapting the intervention to individual users. Conclusion. The Intervention Mapping method, with a clear link between behavioral goals, theoretical methods, and practical strategies and materials, proved useful for systematic development of a digital smoking cessation intervention for adults.
    Type of Medium: Online Resource
    ISSN: 1524-8399 , 1552-6372
    URL: Article
    DOI: 10.1177/1524839916631536
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2036801-X
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  • 5
    Online Resource
    Online Resource
    Plasma Cholinesterase Levels of Nepalese Farmers Following Exposure to Organophosphate Pesticides
    SAGE Publications ; 2017
    In:  Environmental Health Insights Vol. 11 ( 2017-01-01), p. 117863021771926-
    Details
    In: Environmental Health Insights, SAGE Publications, Vol. 11 ( 2017-01-01), p. 117863021771926-
    Abstract: Farmers in developing countries use highly toxic organophosphate pesticides. Thus, the aim of this study was to compare plasma cholinesterase (PChE) enzyme activity before and after exposure to organophosphate pesticides in a real-life setting. Methods: This was a prospective study conducted on 25 farmers spraying organophosphate pesticide in their farm. The PChE level was measured and clinical signs and symptoms of toxicity were asked before and immediately after spraying. Results: The mean level of PChE before and after spraying was 1.41 and 1.29 IU/L, respectively (8.51% decreased). Farmers reported more clinical signs and symptoms of intoxication after spraying pesticides. Conclusions: Increase in acute intoxication signs/symptoms and decrease in PChE indicate a serious public health problem among farmers who use organophosphate pesticides. Appropriate training to the farmers is needed to reduce exposure to organophosphate pesticide.
    Type of Medium: Online Resource
    ISSN: 1178-6302 , 1178-6302
    URL: Article
    DOI: 10.1177/1178630217719269
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2452946-1
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  • 6
    Online Resource
    Online Resource
    Retinal ganglion cell and inner plexiform layer thinning in clinically isolated syndrome
    SAGE Publications ; 2013
    In:  Multiple Sclerosis Journal Vol. 19, No. 14 ( 2013-12), p. 1887-1895
    Details
    In: Multiple Sclerosis Journal, SAGE Publications, Vol. 19, No. 14 ( 2013-12), p. 1887-1895
    Abstract: Axonal and neuronal damage are widely accepted as key events in the disease course of multiple sclerosis. However, it has been unclear to date at which stage in disease evolution neurodegeneration begins and whether neuronal damage can occur even in the absence of acute inflammatory attacks. Objective: To characterize inner retinal layer changes in patients with clinically isolated syndrome (CIS). Method: 45 patients with CIS and age- and sex-matched healthy controls were investigated using spectral domain optical coherence tomography. Patients’ eyes were stratified into the following categories according to history of optic neuritis (ON): eyes with clinically-diagnosed ON (CIS-ON), eyes with suspected subclinical ON (CIS-SON) as indicated by a visual evoked potential latency of 〉 115ms and eyes unaffected by ON (CIS-NON). Results: CIS-NON eyes showed significant reduction of ganglion cell- and inner plexiform layer and a topography similar to that of CIS-ON eyes. Seven eyes were characterized as CIS-SON and likewise showed significant retinal layer thinning. The most pronounced thinning was present in CIS-ON eyes. Conclusion: Our findings indicate that retinal pathology does occur already in CIS. Intraretinal layer segmentation may be an easily applicable, non-invasive method for early detection of retinal pathology in patients unaffected by ON.
    Type of Medium: Online Resource
    ISSN: 1352-4585 , 1477-0970
    URL: Article
    DOI: 10.1177/1352458513489757
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2008225-3
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  • 7
    Online Resource
    Online Resource
    Imitation and Prior Classroom Contact as Determinants of Reciprocal Self-Disclosure
    SAGE Publications ; 1977
    In:  Psychological Reports Vol. 41, No. 1 ( 1977-08), p. 87-91
    Details
    In: Psychological Reports, SAGE Publications, Vol. 41, No. 1 ( 1977-08), p. 87-91
    Abstract: The reciprocity effect in self-disclosure research was tested by controlling for the effects of content imitation and prior degree of contact with the experimenter. Written self-disclosures and objective checklist responses were obtained from 165 subjects on a questionnaire soliciting their reasons for reading non-assigned books. The experimenter disclosed in writing to half the subjects his reasons for reading non-assigned books (these reasons matched two of the checklist reasons); the remaining subjects did not receive the experimenter's disclosure. No content imitation of the experimenter's self-disclosure was found in either checklist or essay responses. No reciprocity effect was found: the experimenter's disclosure and no-disclosure groups did not differ significantly in the length or intimacy of their written disclosures. However, subjects having prior contact with the experimenter as professor wrote longer and more personal essays than subjects unfamiliar with the experimenter, suggesting that the experimenter-subject relationship may be a potent variable in self-disclosure research.
    Type of Medium: Online Resource
    ISSN: 0033-2941 , 1558-691X
    URL: Article
    DOI: 10.2466/pr0.1977.41.1.87
    Language: English
    Publisher: SAGE Publications
    Publication Date: 1977
    detail.hit.zdb_id: 2066930-6
    SSG: 5,2
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  • 8
    Online Resource
    Online Resource
    “After all – It doesn’t kill you to quit smoking”: An explorative analysis of the blog in a smoking cessation intervention
    SAGE Publications ; 2013
    In:  Scandinavian Journal of Public Health Vol. 41, No. 7 ( 2013-11), p. 655-661
    Details
    In: Scandinavian Journal of Public Health, SAGE Publications, Vol. 41, No. 7 ( 2013-11), p. 655-661
    Abstract: Background: A growing body of literature demonstrates internet-based smoking cessation interventions as a promising aid in helping people quit smoking. However, the underlying mechanisms of how these interventions influence the cessation process are still relatively unknown. Several studies have indicated blogging as a potential source in providing social support to users of internet-based smoking cessation interventions and thereby enhance their change of succeeding in quitting. Objective: The study aimed to investigate themes discussed on a blog in an internet-based smoking cessation intervention. In addition, we examined if blogging could provide social support for people in a smoking cessation process. Method: The study was based on messages posted from 1 January 2012 to 29 February 2012 on the blog of the internet-based smoking cessation programme DDSP, operated by the Danish Cancer Society. Messages were coded according to themes using Grounded Theory, and additionally data about bloggers were analyzed. Result: In total, 1663 messages were posted within the 2-month period, and we identified 16 themes. The majority of messages contained personal stories or experiences (53%), provided emotional support (34%) or congratulated other users (17%). The messages were found capable of supplying social support to members on the blog. In addition, we found that only a minority of users who viewed the blog participated actively in posting messages, and only a minority was highly active bloggers. Conclusions: The blog offers a unique platform for informal conversations about quitting smoking and is important in providing social support to people in a smoking cessation process.
    Type of Medium: Online Resource
    ISSN: 1403-4948 , 1651-1905
    URL: Article
    DOI: 10.1177/1403494813489602
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2027122-0
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  • 9
    Online Resource
    Online Resource
    Exercise Tolerance and Quality of Life in Elderly Patients with Chronic Atrial Fibrillation
    SAGE Publications ; 2001
    In:  Journal of Cardiovascular Pharmacology and Therapeutics Vol. 6, No. 1 ( 2001-03), p. 23-29
    Details
    In: Journal of Cardiovascular Pharmacology and Therapeutics, SAGE Publications, Vol. 6, No. 1 ( 2001-03), p. 23-29
    Abstract: Background: Atrial fibrillation is the most common arrhythmia affecting the elderly. Although the risk of cardioembolic stroke is well defined, the effects of chronic atrial fibrillation on exercise tolerance and quality of life have been less well quantified. Methods: We compared a group of 52 elderly patients with chronic atrial fibrillation to a group of 48 control patients in sinus rhythm. Each patient underwent an interview that incorporated the Short Form-36 Health Survey (SF-36) to quantify individual perceptions on quality of life. In addition each person underwent physiologic testing that included a Modified Bruce Protocol exercise tolerance test, 24-hour ambulatory monitor test, and an echocardiogram. Results: Both groups were elderly, 77 vs 76 years of age (P=0.35).The two groups had similar ejection fractions, 55.4% vs 58.4% (P=0.10). The atrial fibrillation patients demonstrated a higher level of comorbidity based on the Charlson Comorbidity Index, 2.46 vs 1.57 (P=0.03). On formal exercise testing there was no statistical difference in exercise duration between the two groups 9.0 vs 10.1 minutes (P=0.24). Similarly the Physical Summary Score (PCS) and the Mental Summary Score (MCS) of the SF-36 quality of life survey did not demonstrate a statistical difference between the two groups. PCS: 43.0 vs 45.9 (P=0.24); MCS: 52.5 vs 55.7 (P=0.07). Conclusions: Despite a higher level of comorbidity, elderly, ambulatory patients with chronic atrial fibrillation demonstrate similar exercise tolerance and report similar quality of life to a group of age-matched control patients in sinus rhythm. There is a cohort of patients in chronic atrial fibrillation in whom a strategy of rate control and anticoagulation may be appropriate.
    Type of Medium: Online Resource
    ISSN: 1074-2484 , 1940-4034
    URL: Article
    DOI: 10.1177/107424840100600103
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2001
    detail.hit.zdb_id: 2230155-0
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  • 10
    Online Resource
    Online Resource
    Preliminary Clinical Results and Mechanical Behavior of a New Double-Layer Carotid Stent
    SAGE Publications ; 2015
    In:  Journal of Endovascular Therapy Vol. 22, No. 4 ( 2015-08), p. 634-639
    Details
    In: Journal of Endovascular Therapy, SAGE Publications, Vol. 22, No. 4 ( 2015-08), p. 634-639
    Abstract: Purpose: To evaluate the in vitro mechanical and clinical implant behavior of a next-generation double-layer stent designed for the carotid artery. Methods: The new double-layer CASPER-RX stent was implanted in 12 patients (median age 69 years; 8 men) with high-grade symptomatic internal carotid artery stenoses (mean 82%). In the in vitro experiments, the CASPER-RX stent (8-×40-mm model) was investigated with respect to its radial force on expansion and the bending stiffness of the stent system and of the stent in its expanded state, as well as the collapse pressure in a thin, flexible sleeve. The wall adaptation of the expanded stents was assessed by fluoroscopy after release in a step and curve model. Results: Technical success was achieved in all patients without complications; there was no peri- or postinterventional stroke and no stroke or restenosis after 6 months. In the experimental studies, the bending stiffness of the stent on the delivery system (154.9 N mm 2 ) was significantly lower than when expanded in a 7-mm flexible tube (467.4 N mm 2 ). The radial force on expansion of the stent to 7 mm was low (0.011 N/mm). The collapse pressure was relatively high (0.56 bar) as a result of the stent’s particular stent structure. The stent exhibited significant foreshortening of 27.6%. The conformability to the wall in the step model was relatively smooth; in the curve model, straightening occurred with consecutive slight stenosis. Conclusion: The first clinical results showed a safe implantation behavior without the occurrence of any ischemia. The structure of the new CASPER-RX stent creates an acceptable flexibility, low radial force, and high collapse pressure. The large foreshortening during implantation should be considered as well as the higher bending stiffness, especially when used in elongated carotid arteries.
    Type of Medium: Online Resource
    ISSN: 1526-6028 , 1545-1550
    URL: Article
    DOI: 10.1177/1526602815593490
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2049858-5
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