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  • S. Karger AG  (3)
  • 2000-2004  (3)
  • 1
    Online Resource
    Online Resource
    Urinary Prostaglandin D Synthase (β-Trace) Excretion Increases in the Early Stage of Diabetes mellitus
    S. Karger AG ; 2001
    In:  Nephron Vol. 87, No. 4 ( 2001), p. 321-327
    Details
    In: Nephron, S. Karger AG, Vol. 87, No. 4 ( 2001), p. 321-327
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 Circulating levels of lipocalin-type prostaglandin D synthase (L-PGDS)/β-trace reportedly increase in renal failure as well as in cardiovascular injuries. We investigated the alterations of L-PGDS in urine and plasma in the early stage of type-2 diabetic patients. 〈 i 〉 Method: 〈 /i 〉 Thirty-six type-2 diabetic patients and 29 normal subjects were studied. Overnight spot urine and plasma samples were obtained in the morning. L-PGDS was measured by ELISA method using anti-L-PGDS antibody. Variables indicating renal function were determined. 〈 i 〉 Results: 〈 /i 〉 Plasma L-PGDS concentration was slightly higher in the patients with diabetes mellitus than in the control subjects, whereas the urinary L-PGDS excretion almost doubled in the diabetic patients as compared with that in the control subjects. Plasma L-PGDS was determined by plasma creatinine (Cr) concentration while urinary L-PGDS excretion was correlated solely with urinary protein excretion. There was no relationship between plasma L-PGDS concentration and urinary L-PGDS excretion. The averaged plasma concentration of L-PGDS in the diabetics with a normal Cr level in plasma, corresponding to that in the controls, was determined by the plasma Cr concentration. On the other hand, the urinary L-PGDS excretion was determined by the amount of proteinuria and greater in the diabetics with a normal Cr level in plasma than in the controls even when the patients exhibited urinary protein excretion equal to that in the control subjects. 〈 i 〉 Conclusions: 〈 /i 〉 Urinary L-PGDS excretion increased in the early stage of kidney injury in patients with type-2 diabetes mellitus. The urinary excretion was correlated independently with urinary protein excretion even when there was no difference in urinary protein or albumin excretions, thereby suggesting that urinary L-PGDS excretion is possibly a more sensitive indicator of renal injuries than proteinuria. Urinary L-PGDS may thus predict the progression of renal injuries in diabetic patients.
    Type of Medium: Online Resource
    ISSN: 1660-8151 , 2235-3186
    URL: Article
    DOI: 10.1159/000045937
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2001
    detail.hit.zdb_id: 2810853-X
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  • 2
    Online Resource
    Online Resource
    Blood Sugar Control Reverses the Increase in Urinary Excretion of Prostaglandin D Synthase in Diabetic Patients
    S. Karger AG ; 2002
    In:  Nephron Vol. 92, No. 1 ( 2002), p. 77-85
    Details
    In: Nephron, S. Karger AG, Vol. 92, No. 1 ( 2002), p. 77-85
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 We investigated basal levels of serum and urinary lipocalin-type prostaglandin D synthase/β-trace (L-PGDS) in type-2 diabetic patients and explored whether glycemic control affects L-PGDS status in another 55 diabetic inpatients with normoalbuminuria. 〈 i 〉 Methods: 〈 /i 〉 Fifty-five type-2 diabetic outpatients (HbA1c, 9.14 ± 0.20%; creatinine (Cr), 85.1 ± 2.4 µmol/l), and 55 age-matched healthy control subjects were recruited. Serum and urinary levels of L-PGDS were determined with respect to the stage of diabetic nephropathy. The L-PGDS was localized by immunohistochemistry. 〈 i 〉 Results: 〈 /i 〉 The urinary L-PGDS index increased in diabetic patients, compared with the controls (234.8 ± 27.4 vs. 73.8 ± 7.8 µg/mmol Cr, p 〈 0.001). Even in normoalbuminuric patients as well as in microalbuminuric patients, urinary L-PGDS indexes were higher than the controls (166.0 ± 21.1, p 〈 0.0001 and 338.6 ± 62.5 µg/mmol Cr, p 〈 0.0001, respectively), although the serum L-PGDS level was equal to that in the control subjects. Multiple regression analysis revealed that the urinary L-PGDS index was predicted solely by glucose levels and type-IV collagen index, whereas the serum L-PGDS was determined mainly by age and serum Cr. Glycemic control reduced the urinary L-PGDS index towards the normal range in diabetic patients with normoalbuminuria (172.3 ± 6.6 vs. 118.1 ± 2.6 (SE) µg/mmol Cr, p 〈 0.0001). Immunohistochemistry showed that L-PGDS was uniquely present in the renal tubules in diabetes while in nondiabetics, L-PGDS occurred solely in the peritubular interstitium, not in the tubular cells. 〈 i 〉 Conclusion: 〈 /i 〉 Inadequate glycemic control is responsible for urinary L-PGDS excretion in the diabetic patients. Urinary L-PGDS is useful to predict subclinical renal injury associated with type-2 diabetes.
    Type of Medium: Online Resource
    ISSN: 1660-8151 , 2235-3186
    URL: Article
    DOI: 10.1159/000064473
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2002
    detail.hit.zdb_id: 2810853-X
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  • 3
    Online Resource
    Online Resource
    Correlation between Laminin-5 γ2 Chain Expression and Epidermal Growth Factor Receptor Expression and Its Clinicopathological Significance in Squamous Cell Carcinoma of the Tongue
    S. Karger AG ; 2002
    In:  Oncology Vol. 62, No. 4 ( 2002), p. 318-326
    Details
    In: Oncology, S. Karger AG, Vol. 62, No. 4 ( 2002), p. 318-326
    Abstract: Recent investigations have revealed that growth factors may influence the invasive activity of tumor cells. Expression of laminin-5 γ2 chain (LN-5 γ2) and epidermal growth factor receptor (EGFR) in squamous cell carcinomas of the tongue in 104 patients with stage II, III, and IVA, B (excluding the cases with distant metastasis) was examined immunohistochemically to determine the correlation between the two molecules and the associations with the clinicopathological features of each tumor. LN-5 γ2 expression was clearly demonstrated in the cytoplasm and EGFR in the cell membranes of cancer cells. A significant increase in positivity for LN-5 γ2 was observed in tumors showing poor differentiation (p 〈 0.001), infiltrative growth (p 〈 0.001), and deep invasion (p = 0.038). In a multivariate analysis, increased positivity for LN-5 γ2 was an independent predictor of an unfavorable outcome (p 〈 0.001). A significant increase in positivity for EGFR was observed in tumors showing infiltrative growth (p = 0.032) and poor prognosis (p = 0.008). The LN-5 γ2 expression was correlated significantly with EGFR expression (p 〈 0.001). Patients with tumor positivity for both molecules showed the worst prognosis (p 〈 0.001). LN-5 γ2 overexpression and EGFR overexpression is evident in tumors showing infiltrative growth, suggesting that EGFR may influence the invasive activity of tumor cells through overexpression of LN-5 γ2.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000065063
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2002
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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