In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 98, No. 7 ( 2001-03-27), p. 4136-4141
Abstract:
The complete genome sequence of Caulobacter
crescentus was determined to be 4,016,942 base pairs in a
single circular chromosome encoding 3,767 genes. This organism, which grows in a dilute aquatic environment, coordinates the cell division
cycle and multiple cell differentiation events. With the annotated genome sequence, a full description of the genetic network that
controls bacterial differentiation, cell growth, and cell cycle progression is within reach. Two-component signal transduction proteins
are known to play a significant role in cell cycle progression. Genome analysis revealed that the C. crescentus genome encodes
a significantly higher number of these signaling proteins (105) than any bacterial genome sequenced thus far. Another regulatory mechanism
involved in cell cycle progression is DNA methylation. The occurrence of the recognition sequence for an essential DNA methylating enzyme
that is required for cell cycle regulation is severely limited and shows a bias to intergenic regions. The genome contains multiple
clusters of genes encoding proteins essential for survival in a nutrient poor habitat. Included are those involved in chemotaxis, outer
membrane channel function, degradation of aromatic ring compounds, and the breakdown of plant-derived carbon sources, in addition to many
extracytoplasmic function sigma factors, providing the organism with the ability to respond to a wide range of environmental fluctuations. C. crescentus is, to our knowledge, the first
free-living α-class proteobacterium to be sequenced and will serve as a foundation for exploring the biology of this group of bacteria, which
includes the obligate endosymbiont and human pathogen Rickettsia
prowazekii , the plant pathogen Agrobacterium
tumefaciens , and the bovine and human pathogen Brucella
abortus .
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.061029298
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
2001
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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