In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2004, No. 20 ( 2004-10), p. 4028-4035
Abstract:
Two novel Cu II complexes [Cu(CMQA)(H 2 O)] ( 1 ) (CMQA = N ‐carboxymethyl‐ L ‐methionine‐ N ′‐8‐quinolylamide) and [Cu(MQA)(OAc)] ( 2 ) (MQA = L ‐methionine‐ N ′‐8‐quinolylamide, OAc = CH 3 COO − ) have been synthesized and structurally characterized. Complex 1 crystallizes in the orthorhombic system with space group P 2 1 2 1 2 1 [ a = 5.556(1) Å, b = 15.002(3) Å, c = 20.886(4) Å] while complex 2 crystallizes in the monoclinic system with space group C 2 [ a = 28.463(6) Å, b = 5.264(1) Å, c = 13.345(3) Å, β = 109.142(3)°]. In both complexes the Cu II center is coordinated by three N atoms of the ligand and one O atom of H 2 O ( 1 ) or OAc ( 2 ). The in vitro cytotoxicity of both complexes and their corresponding ligands have been tested against the murine leukemia P‐388 and lung adenocarcinoma A‐549 cell lines. Complex 2 shows a potent activity against both cell lines with an inhibitory rate of 100% for the murine leukemia P‐388 cell line and 93.4% for the lung adenocarcinoma A‐549 cell line at a concentration of 10 −6 mol·L −1 , while complex 1 shows only a marginal activity against the same cell lines. The reactivity of the two complexes towards γ‐glutathione (GSH) has been investigated and is discussed in association with their different cytotoxicity. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2004:20
DOI:
10.1002/ejic.200400357
Language:
English
Publisher:
Wiley
Publication Date:
2004
detail.hit.zdb_id:
1475009-0
Permalink