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  • 1
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    Comparison of conditional power criteria for early termination of clinical trials
    Elsevier BV ; 2004
    In:  Computational Statistics & Data Analysis Vol. 46, No. 2 ( 2004-6), p. 377-395
    Details
    In: Computational Statistics & Data Analysis, Elsevier BV, Vol. 46, No. 2 ( 2004-6), p. 377-395
    Type of Medium: Online Resource
    ISSN: 0167-9473
    URL: Article
    DOI: 10.1016/S0167-9473(03)00172-5
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2004
    detail.hit.zdb_id: 1478763-5
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  • 2
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    Impact of Anterior Commissure Involvement on Local Control of Early Glottic Carcinoma Treated by Laser Microresection
    Wiley ; 2004
    In:  The Laryngoscope Vol. 114, No. 8 ( 2004-08), p. 1485-1491
    Details
    In: The Laryngoscope, Wiley, Vol. 114, No. 8 ( 2004-08), p. 1485-1491
    Abstract: Objectives: To analyze the impact of anterior commissure involvement on local control, survival, and laryngeal preservation in patients with early glottic cancer (pT1a–pT2a) treated with unimodality laser microsurgical resection. Study Design: Retrospective review of 263 patients with early glottic cancer treated between 1986 and 1996. Methods: Data on local control and overall survival rates were analyzed and calculated by the Kaplan‐Meier method; the larynx preservation rates were given absolutely. Results: Among 158 patients presenting with T1a glottic cancer, the anterior commissure was involved in 28 cases; the 5‐year local control rate was 84%, and the larynx preservation rate was 93%. In the 130 cases without anterior commissure involvement, the 5‐year local control rate was 90.0% and the corresponding larynx preservation rate 99%. In the T1b category consisting of 30 patients, anterior commissure involvement was observed in 16 patients; the 5‐year local control rate was 73%, and the larynx preservation rate was 88%. In the 14 cases without anterior commissure involvement, the 5‐year local control rate was 92% and the corresponding larynx preservation rate 100%. Seventy‐five patients had T2a glottic carcinomas, with normal vocal cord movement. The anterior commissure was involved in 45 cases; the 5‐year local control rate was 79%, and the larynx preservation rate was 93%. In the 30 cases without anterior commissure involvement, the 5‐year local control rate was 74.0% and the corresponding larynx preservation rate 97%. Conclusions: This study shows the effectiveness of laser microsurgery for early glottic carcinoma regardless of anterior commissure involvement at presentation. This method can be performed as an outpatient procedure, even when conducting reresections.
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Article
    DOI: 10.1097/00005537-200408000-00031
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2026089-1
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  • 3
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    Improvement of Visual Acuity in Eyes with Diabetic Macular Edema after Treatment with Pars plana Vitrectomy
    S. Karger AG ; 2004
    In:  Ophthalmologica Vol. 218, No. 6 ( 2004), p. 378-384
    Details
    In: Ophthalmologica, S. Karger AG, Vol. 218, No. 6 ( 2004), p. 378-384
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Diabetic macular edema (DME) is the leading cause of severe visual loss in patients with diabetic retinopathy. This is so despite the fact that argon laser photocoagulation of the macula (M-ALC) has been shown to be beneficial. Recently, it has been suggested that pars plana vitrectomy (PPV) can lead to the resolution of DME and stop the deterioration of central visual acuity. 〈 i 〉 Purpose: 〈 /i 〉 To explore the potential benefit of PPV for the treatment of DME. 〈 i 〉 Patients and Methods: 〈 /i 〉 PPV was carried out in 30 eyes of 21 consecutive patients (median age 71 years, range 61–88 years) with type II diabetes mellitus suffering from DME. 23 eyes had non-proliferative diabetic retinopathy (NPDR) and 7 eyes had proliferative diabetic retinopathy (PDR) in addition to DME. Posterior vitreous detachment had to be carried out in all cases. If epiretinal membranes were present (23 eyes), they were removed. In 13 eyes (initially 11 eyes) the internal limiting membrane (ILM) was also removed. Prior to PPV 8 eyes had received M-ALC. Three eyes had M-ALC after PPV. One eye developed a retinal detachment 6 weeks after PPV and was excluded form the analysis. After an initial treatment failure two eyes underwent repeat PPV with peeling of the ILM. Both eyes of another patient had 2 repeat PPVs because of recurrent vitreous hemorrhage. Median follow-up was 16 months (range 1–62 months). 〈 i 〉 Results: 〈 /i 〉 Following PPV the macula flattened or became attached in 20/27 (74%) eyes. 15/18 (83%) eyes showed reduction or disapearance of leakage during fluorescein-angiography. Central visual acuity increased by two to six lines in 15/27 (56%) for the whole group at 6 months after PPV. For the subgroup (18 eyes) for which the evolution of visual acuity prior to PPV could be documented mean and median visual acuity had decreased markedly from 0.26 ± 0.19 resp. 0.2 (range 0.03–0.6) to 0.12 ± 0.09 resp. 0.1 (range 0.02–0.4) during the 12 months preceding PPV and increased to 0.28 ± 0.23 resp. 0.2 (range 0.03–0.8) during the 12 months following PPV. 〈 i 〉 Conclusion: 〈 /i 〉 PPV almost always results in a reduction and often complete disappearance of DME as evidenced by ophthalmoscopy and fluorescein-angiography. Most importantly, central visual acuity often increases, sometimes to a very large extent with dramatic improvement in quality of life of the patients.
    Type of Medium: Online Resource
    ISSN: 0030-3755 , 1423-0267
    URL: Article
    DOI: 10.1159/000080940
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1483531-9
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  • 4
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    Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer-cell–induced apoptosis
    American Society of Hematology ; 2002
    In:  Blood Vol. 100, No. 8 ( 2002-10-15), p. 2891-2898
    Details
    In: Blood, American Society of Hematology, Vol. 100, No. 8 ( 2002-10-15), p. 2891-2898
    Abstract: In 65 patients with hemophagocytic lymphohistiocytosis (HLH), we found an as yet undescribed heterogeneity of defects in cellular cytotoxicity when assay conditions were modified by the incubation time, the presence of mitogen, or interleukin-2 (IL-2). The standard 4-hour natural killer (NK) test against K562 targets was negative in all patients. In patients deficient in type 1 (n = 21), type 2 (n = 5), and type 4 (n = 8) HLH, negative NK function could be reconstituted by mitogen, by IL-2, or by prolongation of the incubation time (16 hours), respectively. Most patients (n = 31) displayed the type 3 defect, defined by a lack of any cellular cytotoxicity independent of assay variations. The characteristic hypercytokinemia also concerned counterregulatory cytokines, such as proinflammatory interferon-γ (IFN-γ), simultaneously elevated with suppressive IL-10 in 38% of types 1–, 2–, and 4–deficient patients and in 71% of type 3–deficient patients. Elevated IFN-γ alone correlated with high liver enzymes, but sCD95-ligand and sCD25 did not—though these markers were expected to indicate the extent of histiocytic organ infiltration. Outcome analysis revealed more deaths in patients with type 3 deficiency (P = .017). Molecular defects were associated with homozygously mutated perforin only in 4 patients, but other type 3 patients expressed normal transcripts of effector molecules for target-cell apoptosis, including perforin and granzyme family members, as demonstrated by RNase protection analysis. Thus, target-cell recognition or differentiation defects are likely to explain this severe phenotype in HLH. Hyperactive phagocytes combined with NK defects may imply defects on the level of the antigen-presenting cell.
    Type of Medium: Online Resource
    ISSN: 1528-0020 , 0006-4971
    URL: Article
    DOI: 10.1182/blood-2001-12-0260
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2002
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 5
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    Ultrasound-guided fine-needle aspiration cytology in the early detection of melanoma metastases
    Wiley ; 2000
    In:  Cancer Vol. 90, No. 3 ( 2000-06-25), p. 186-193
    Details
    In: Cancer, Wiley, Vol. 90, No. 3 ( 2000-06-25), p. 186-193
    Type of Medium: Online Resource
    ISSN: 0008-543X
    URL: Issue
    URL: Article
    DOI: 10.1002/1097-0142(20000625)90:3〈〉1.0.CO;2-R
    DOI: 10.1002/1097-0142(20000625)90:3〈186::AID-CNCR7〉3.0.CO;2-O
    Language: English
    Publisher: Wiley
    Publication Date: 2000
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 1429-1
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  • 6
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    The effect of kinaesthetic mobilization compared to standard mobilization on respiratory function with post-op patients after aortal coronary bypass surgery : und weitere relevante Faktoren
    Hogrefe Publishing Group ; 2003
    In:  Pflege Vol. 16, No. 4 ( 2003-08-01), p. 205-215
    Details
    In: Pflege, Hogrefe Publishing Group, Vol. 16, No. 4 ( 2003-08-01), p. 205-215
    Abstract: Presently no relevant nursing data exist in Germany on the effect of mobilization according to kinaesthetic principles on the physiological system, on locomotion and the sensory system. The effect of two different versions of mobilization was measured in a unicentric, open, randomized study with two parallel groups from December 1999 to October 2000 in the intermediate ICU for patients after heart surgery at Ulm University Hospital. The aim was, to show superiority of kinaesthetic mobilization, compared to empirically developed standard mobilization on patients after aortal coronary bypass surgery, with reference to respiratory function. The two protocols of mobilization were carefully coordinated with precise plans of action and timing. A total of 104 subjects were randomized to the two groups. In the kinaesthetic mobilization group (n = 52) median age was 67.5 years, ten (19.2%) were female and 42 (80.8%) were male. In the standard mobilization group (n = 52) median age was 69 years, eight (15.4%) were female and 44 (84.6%) were male. The main outcome variable was the respiratory minute volume 30 minutes after the second mobilization minus the respiratory minute volume prior to the second mobilization. The median change in respiratory minute volume was 0.4 ltr/min. (–5.1 to +5.3) in the group with kinaesthetic mobilization and median 0.3 ltr/min (–6.0 to +9.1) in the standard mobilization group. Superiority of kinaesthetic mobilization compared to standard mobilization could not be proven (p = 0.38). Also in the secondary outcome variables the kinaesthetic mobilization showed no superiority over standard mobilization. The respiratory minute volume data within points of measure show that subjects in the kinaesthetic group have less extreme results ( 〉 12 ltr.). In the area 〈 5 ltr. there is a similar tendency. This may point out that regulation between movement of body, respiration and circulatory system occurs more continuous in kinaesthetic mobilization than the standard mobilization. A similar tendency was seen in the secondary outcomes variables. Subjectively nurses noted that kinaesthetic mobilization was less strenuous than standard mobilization, even though subjects in the kinaesthetic group showed more mobility restriction (37%) than in the standard group (15%). From before to after the first mobilization the percentage of subjects needing less pain medication was higher in the kinaesthetic group (35%), compared to the standard group (19%). There were no serious adverse events in either group. The concept of kinaesthetic mobilization showed no negative effect on subjects compared to empirically developed standard mobilization. There was no diagnosis of pneumonia and none of instabile sternum on any of the subjects in this study. Also, there was no negative effect on the sternum due to the light support arms gave to sitting up and rotating movements in the area of thorax and pelvis on subjects in the kinaesthetic group. The subjects early trust in their own varied movement and the possible effects of kinaesthetic mobilization in later phases of recuperation was not explored in this study.
    Type of Medium: Online Resource
    ISSN: 1012-5302 , 1664-283X
    URL: Article
    DOI: 10.1024/1012-5302.16.4.205
    RVK:
    XA 10000
    Language: German
    Publisher: Hogrefe Publishing Group
    Publication Date: 2003
    detail.hit.zdb_id: 2077531-3
    detail.hit.zdb_id: 645005-2
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  • 7
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    Association between the Clinical Presentation and Epidemiological Features of Familial Prostate Cancer in Patients Selected for Radical Prostatectomy
    Elsevier BV ; 2003
    In:  European Urology Vol. 43, No. 6 ( 2003-6), p. 615-621
    Details
    In: European Urology, Elsevier BV, Vol. 43, No. 6 ( 2003-6), p. 615-621
    Type of Medium: Online Resource
    ISSN: 0302-2838
    URL: Article
    DOI: 10.1016/S0302-2838(03)00146-5
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2003
    detail.hit.zdb_id: 1482253-2
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  • 8
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    A Long-Term Follow-Up Study after Split-Course Irradiation with Concurrent Chemotherapy (Carboplatin) for Locally Advanced Head and Neck Cancer and a Review of the Literature
    S. Karger AG ; 2004
    In:  ORL Vol. 66, No. 6 ( 2004), p. 325-331
    Details
    In: ORL, S. Karger AG, Vol. 66, No. 6 ( 2004), p. 325-331
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Radiotherapy is often the primary treatment for advanced head and neck cancer, but the rates of locoregional recurrence are high and survival is poor. The purpose of this study was to evaluate the efficacy and toxicity of split-course radiotherapy combined with concurrent carboplatin chemotherapy after long-term follow-up. 〈 i 〉 Patients and Methods: 〈 /i 〉 From August 1987 to May 1994, 66 patients (54 males, 12 females, mean age 58 years) with advanced inoperable oropharynx cancer were treated at the University of Göttingen, Göttingen, Germany. Tumour localization in the oropharynx was: tonsil (n = 33), base of tongue (n = 28), soft palate (n = 2) and posterior pharyngeal wall (n = 3). Forty-nine patients presented with a T 〈 sub 〉 4 〈 /sub 〉 tumour, 15 were T 〈 sub 〉 3 〈 /sub 〉 and 2 were T 〈 sub 〉 2 〈 /sub 〉 . The nodal status was distributed as follows: N0 (n = 7), N1 (n = 5), N2 (n = 28) and N3 (n = 26). A total radiation dose of 5,670 cGy was applied in 6 weeks as a split-course regimen (2 × 2.1 Gy/day, 4 times a week, weeks 1 and 2 and weeks 5 and 6). Concomitant carboplatin chemotherapy was given each radiotherapy day before irradiation (50 mg/m 〈 sup 〉 2 〈 /sup 〉 ). 〈 i 〉 Results: 〈 /i 〉 In December 2003, 12 patients were still alive. Survivors have reached a maximum follow-up of 170.5 months (median 14.3 months). Two- and 5-year overall survival was 32 and 18%, 2-year disease-free survival 27%. Therapy was tolerated moderately (19% grade 3 skin reaction, 26% grade 3 mucositis, 23% grade 3 xerostomia, 20% grade 3 leucopenia, 8% grade 3 thrombopenia and 25% grade 3 anaemia). 〈 i 〉 Conclusion: 〈 /i 〉 Split-course radiotherapy and concomitant carboplatin chemotherapy can be carried out in inoperable head and neck cancer without severe toxicity. After long-term follow-up, survival rates are unfavourable in this poor prognostic group of patients.
    Type of Medium: Online Resource
    ISSN: 0301-1569 , 1423-0275
    URL: Article
    DOI: 10.1159/000081890
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2004
    detail.hit.zdb_id: 1483533-2
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  • 9
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    Pseudophakic retinal detachment after uneventful phacoemulsification and subsequent neodymium: YAG capsulotomy for capsule opacification
    Ovid Technologies (Wolters Kluwer Health) ; 2003
    In:  Journal of Cataract and Refractive Surgery Vol. 29, No. 5 ( 2003-05), p. 925-929
    Details
    In: Journal of Cataract and Refractive Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 5 ( 2003-05), p. 925-929
    Type of Medium: Online Resource
    ISSN: 0886-3350
    URL: Article
    DOI: 10.1016/S0886-3350(02)01820-5
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2003
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  • 10
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    Effectiveness of a Multifaceted Intervention on Falls in Nursing Home Residents
    Wiley ; 2003
    In:  Journal of the American Geriatrics Society Vol. 51, No. 3 ( 2003-03), p. 306-313
    Details
    In: Journal of the American Geriatrics Society, Wiley, Vol. 51, No. 3 ( 2003-03), p. 306-313
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Article
    DOI: 10.1046/j.1532-5415.2003.51103.x
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 2040494-3
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