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  • 1
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 113 (2000), S. 9353-9354 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: This recent paper uses multiconfiguration self-consistent field (MCSCF) wave functions to study the structure of Si(001). The results are at odds with density functional theory predictions and experiment. This comment shows that dynamic correlation, which is neglected in MCSCF calculations, is essential for reliable predictions of the geometry of Si(001). © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 4 (1951), S. 209-215 
    ISSN: 0001-5520
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 51-55 
    ISSN: 1432-2218
    Keywords: Key words: Pneumoperitoneum, physiopathology — Laparoscopy, side effects — Locoregional therapy — Technology, medical
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Multimodal therapy is used increasingly in advanced gastrointestinal tumors. Potential benefits of using an intraoperative adjuvant therapy during laparoscopy for cancer have been documented in animal studies. The aim of this study was to develop a device that could deliver such an intraoperative drug therapy. Methods: We developed a micropump suitable for minimally invasive surgery procedures that allowed microdroplets of therapeutic substance to be distributed into the pneumoperitoneum (CO2), creating a ``therapeutic pneumoperitoneum.'' A closed-loop control system regulates drug delivery according to the gas flow. In vitro, the micropump is able to aerosolize various aqueous and ethanol solutions, including cytostatic and bacteriostatic drugs and adhesion-modulating agents. The size of the microdroplets has been optimized to prevent visual artifacts. Results: The micropump was tested in an animal model (pig). The system was inserted into a 5-mm trocar. After insufflation of a 12-mm CO2 pneumoperitoneum, laparoscopic sigmoid colon resections could be performed with no special difficulties. No fog developed, and no system-related complication was observed. At autopsy, the active principle was distributed to all exposed peritoneal surfaces. Conclusions: As opposed to conventional peritoneal washing, therapeutic pneumoperitoneum reaches the entire peritoneal surface, allowing an optimal drug distribution. Drug diffusion into the tissues is enhanced by the intraperitoneal pressure. Precise determination of the instantaneous and total drug quantity is possible. Therefore, this drug delivery system has several advantages over conventional irrigation. Its potential domains of application are locoregional cancer therapy, prevention of port-site recurrences, immunomodulation, analgesia, peritonitis, and prevention of postoperative adhesions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Kardiologie 89 (2000), S. 606-611 
    ISSN: 1435-1285
    Keywords: Key words Adult congenital cardiac disease ; contraception ; birth control ; pregnancy ; Schlüsselwörter Angeborene Herzfehler ; Erwachsene mit angeborenen Herzfehlern ; Kontrazeption ; Schwangerschaft
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Zahl der Frauen, die mit einem angeborenen Herzfehler das Erwachsenenalter erreicht, nimmt zu. Leider existieren zu den verschiedenen kontrazeptiven Möglichkeiten und ihren Risiken speziell für diese Patientinnen keine prospektiven Daten. Die meisten Frauen mit angeborenen Herzfehlern können gefahrlos orale Kontrazeptiva anwenden, besonders die modernen niedrig-dosierten Präparate. Hoch-Risikopatientinnen sind solche Patientinnen, die ein erhöhtes Risiko für thrombembolische Komplikationen aufweisen (besonders bei Zyanose, pulmonaler Hypertonie, Eisenmenger-Reaktion, Herzrhythmus-Störungen), die zu Flüssigkeitsretention neigen (vor allem bei eingeschränkter Ventrikelfunktion und Herzinsuffizienz), eine arterielle Hypertonie haben (z.B. Aortenisthmusstenosen), ein erhöhtes Endokarditis-Risiko aufweisen oder bei denen Lipidstoffwechselstörungen vorliegen. Orale Kontrazeptiva sollten bei Frauen mit erhöhtem thromboembolischen Risiko vermieden werden. Intrauterin-Pessare (IUP) haben keine metabolischen Effekte und nur ein geringes Endokarditis-Risiko, besonders neue gestagenhaltige Pessare. Subdermale Gestagen-Implantate (Norplant, Implanon) werden im Ausland bereits erfolgreich verwendet und könnten in den kommenden Jahren in Deutschland auch bei Patientinnen mit angeborenen Herzfehlern breitere Anwendung finden. Barrieremethoden sind nebenwirkungsarm, haben aber besonders bei jungen Patientinnen hohe Versagerquoten, was bei Patientinnen für die eine Schwangerschaft kontraindiziert ist (z.B. Eisenmenger-Reaktion) inakzeptabel ist. In diesen Fällen ist weiterhin eine Tubensterilisation anzuraten. Die nachfolgende Übersicht stellt die heute möglichen Verfahren der Kontrazeption vor, wobei speziell auf deren Wirkungen und potentielle Risiken für Frauen mit angeborenen Herzfehlern eingegangen wird.
    Notes: Summary The number of women with congenital cardiac disease, who mature into adulthood is increasing. Unfortunately, there are no prospective data published about the relative risk of different forms of contraception for these patients. Most women with congenital cardiac disease can safely use oral contracetives, especially low-estrogen combination or progestin-only preparations, with the exception of those, who are at particular risk because of thrombembolic complications (especially in cyanosis, pulmonary hypertension, Eisenmenger reaction, rhythm disturbances), fluid retention (especially in reduced ventricular function and congestive heart failure), arterial hypertension (important in coarctation), infectious complications (endocarditis) or hyperlipidemia. Oral contraceptives should be avoided in patients at increased risk for thrombembolic events. Intrauterine devices are very effective, have no metabolic side effects and merely cary a small risk of endocarditis. Newer devices containing progesterone only may put the patients at a still smaller risk. Contraceptive subdermal implants (e.g. levonorgestrel) are used with good results in the United States for patients with contraindications to estrogen-containing oral contraceptives and may well become more widely accepted in patients in Germany in the coming years. Barrier methods can be used, but have a higher failure rate, which may be inacceptable in patients at risk (e.g. Eisenmenger‘s). Especially in Eisenmenger‘s, permanent sterilisation should be advised.
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  • 6
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus Adenium Boehmianum Schinz (ganze Pflanzen) wurden drei krist. herzaktive Glykoside isoliert. Der in grösster Menge (0,107%) erhaltene Stoff dürfte mit dem von Boehm aus derselben Pflanze erhaltenen Echujin identisch sein. Ein zweites Glykosid (0,0327% Ausbeute) war mit Somalin (V) identisch. Das dritte Glykosid wurde nur in kleiner Menge (0,0054%) erhalten und dürfte neu sein, wir nennen es Abobiosid. Nach Acetylierung der amorphen Anteile liess sich als vierter krist. Stoff (0,019%) Digitalinum-verum-hexacetat (XXIII) isolieren.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 36 (1953), S. 85-87 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Honghelosid G, ein Nebenglykosid aus den Wurzeln von A denium Honghel aus Nigeria, wurde mit der tiefschmelzenden Modifikation von Somalin identifiziert. Dieser Stoff konnte in geringer Menge auch in den Stengeln von Adenium Honghel aus Nigeria gefunden werden.
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