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  • 1
    Electronic Resource
    Electronic Resource
    Intralesional injection of enoxaparin in benign symmetrical lipomatosis: an alternative to surgery? (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04102.x
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  • 2
    Electronic Resource
    Electronic Resource
    Localized mucinosis subsequent to erysipelas (2004)
    Oxford, UK : Blackwell Publishing Ltd.
    Journal of the European Academy of Dermatology and Venereology 18 (2004), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.2004.00773.x
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  • 3
    Electronic Resource
    Electronic Resource
    Dapsone in rosacea fulminans (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 15 (2001), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Rosacea fulminans is a rare disease with female predominance characterized by abrupt onset of pustules, papules, and confluent nodules on the face. The conventional treatment consists of systemic glucocorticoids and isotretinoin. We present the case of a 56-year-old woman with a marked facial papulopustular eruption that had followed an initial period of severe seborrhoea. Conventional treatment produced no clear improvement. Dapsone treatment achieved complete healing in 5 weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2001.00325.x
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  • 4
    Electronic Resource
    Electronic Resource
    Granulomatous mycosis fungoides. Report of two cases and review of the literature (2000)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 14 (2000), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Granulomatous mycosis fungoides is an extremely rare type of cutaneous T-cell lymphoma. Two cases are described and checked for clinical, histological and therapeutic differences to other variants of mycosis fungoides.Case reports Case 1: a 52-year-old patient with livid plaques covering the whole integument. Histological findings showed granulomas with multinuclear giant cells in addition to a malignant lymphohistiocytic infiltrate (monoclonal T-cell receptor (TCR) -γ rearrangement). Despite various chemotherapeutic regimens, progression to tumour stage was observed. Case 2: an 88-year-old man with plaques and ulcerating tumours on the trunk and head. Histological findings showed malignant T-lymphocyte infiltrate (monoclonal TCR-γ rearrangement) and granulomas with multinuclear foreign-body giant cells. Complete regression of all lesions was achieved using both local psoralen-ultraviolet A and electron radiotherapy.Conclusions The diagnosis of a granulomatous mycosis fungoides depends exclusively on the histological demonstration of granulomas. Distinct clinical characteristics are not present. Apart from granuloma formation, no other noticeable histological features are evident. The presence of granulomas in mycosis fungoides does not have prognostic implications, as cases with aggressive, but also with a prolonged course have been described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2000.00047.x
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  • 5
    Electronic Resource
    Electronic Resource
    BIOSYNTHESIS OF VITAMIN B2 (RIBOFLAVIN) (2000)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Nutrition 20 (2000), S. 153-167 
    Details
    ISSN: 0199-9885
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The biosynthesis of one riboflavin molecule requires one molecule of GTP and two molecules of ribulose 5-phosphate as substrates. The imidazole ring of GTP is hydrolytically opened, yielding a 4,5-diaminopyrimidine which is converted to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione by a sequence of deamination, side chain reduction and dephosphorylation. Condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3,4-dihydroxy-2-butanone 4-phosphate obtained from ribulose 5-phosphate affords 6,7-dimethyl-8-ribityllumazine. Dismutation of the lumazine derivative yields riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is recycled in the biosynthetic pathway. The structure of the biosynthetic enzyme, 6,7-dimethyl-8-ribityllumazine synthase, has been studied in considerable detail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.nutr.20.1.153
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  • 6
    Electronic Resource
    Electronic Resource
    Reynolds number effects in the near-wall region of turbulent channel flows (2001)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 13 (2001), S. 1755-1767 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The continuity and momentum equations do not imply a Reynolds number dependence of turbulence data when wall variables are used for normalization. However, experimental and numerical results show a Reynolds number dependence of turbulence intensity very close to the wall. The cause of this is explained. It results from the behavior of a sink term in the dissipation rate equation which shows a Reynolds number dependence in the limit of two-component two-dimensional turbulence as it exists close to walls. Away from the near-wall region the Reynolds number dependence originates from the streamwise pressure gradient which enters into the equations for the turbulent kinetic energy and turbulent dissipation rate through the gradient production processes. The low-Reynolds number effects in turbulent channel flow were investigated experimentally using the laser Doppler anemometry (LDA) measuring technique. A new method was used to eliminate the influence of the limited spatial resolution of the LDA measuring control volume. Results are presented for the limiting behavior of the turbulent intensity near the wall and its variation with the Reynolds number. The present LDA measurements confirm the trend in the data of direct numerical simulations. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1367369
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  • 7
    Electronic Resource
    Electronic Resource
    NMDA receptors influence the intracellular calcium concen-tration and the expression of differentiation markers in HaCaT cells (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ionotropic glutamate receptors (ligand-gated, ion-channel proteins) of the N-methyl-d-aspartate (NMDA) receptor type could enable a transmembranous calcium influx from the extracellular space. Though ionotropic glutamate receptors are predominantly neuronal receptors, they are also expressed in non-neuronal tissues like keratinocytes. Therefore, investigations were performed to study the function of NMDA receptors in HaCaT cells. The intracellular calcium concentration of HaCaT cells was studied under the influence of the selective receptor agonist NMDA and the selective NMDA antagonist MK-801. The proliferation of HaCaT cells was investigated using the crystal-violet method. Furthermore, the expression of Cytokeratin 10 and Filaggrin was examined in HaCaT cells after blocking NMDA receptors with MK-801. Using NMDA, there was a significant increase in the number of HaCaT cells showing elevated intracellular calcium concentration, at a dose between 25 µm and 1 mm (up to 84.6% of cells). The NMDA-associated calcium influx could be significantly suppressed by prior application of MK-801. There was no influence of NMDA on the proliferation of HaCaT cells. There was also no cytotoxic effect of NMDA (up to 1 mm). The expression of Cytokeratin 10 and Filaggrin could be suppressed by blocking NMDA receptors with MK-801. The investigations show that glutamate receptors of the NMDA-type play a role in the differentiation of HaCaT cells by regulating their intracellular calcium concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.0212at.x
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  • 8
    Electronic Resource
    Electronic Resource
    Treatment of recalcitrant psoriasis with daclizumab (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.03991.x
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  • 9
    Electronic Resource
    Electronic Resource
    Antitumour necrosis factor-α antibodies (infliximab) in the treatment of a patient with toxic epidermal necrolysis (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.46833.x
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  • 10
    Electronic Resource
    Electronic Resource
    Diagnostic impact and sensitivity of skin biopsies in Sneddon's syndrome. A report of 15 cases (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Sneddon's syndrome is defined as a combination of idiopathic livedo racemosa generalisata and symptoms of cerebrovascular defect. The disease usually starts with vascular symptoms in the epidermis, with neurological deficits becoming evident later. For this reason, histological examination of skin biopsies and determination of arteriolar occlusion is of particular importance for reliable categorization and early diagnosis. To date, these methods have been considered to be too insensitive. Objectives To evaluate the sensitivity of skin biopsies in Sneddon's syndrome. Methods We took a total of five deep punch biopsies (4 mm) from different areas of the livedo (three from white and two from red areas) in 15 patients. Present knowledge of the pathogenic relationships and the particular anatomical features of the skin were taken into account. Results The method had a sensitivity of 27% with one biopsy, 53% with two biopsies and 80% with three biopsies taken from white areas in all cases. Conclusions Skin biopsies using the method presented achieved a high sensitivity, suggesting that the diagnosis in clinically suspected cases could be confirmed in the majority of cases with this technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04348.x
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