ISSN:
1573-7039
Keywords:
mammary carcinogenesis
;
1-methyl-1-nitrosourea
;
premalignant lesions
;
malignant lesions
;
animal model
;
rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Premalignant and malignant stages of mammary carcinogenesis can be rapidly induced by injecting female rats i.p. with 1-methyl-1-nitrosourea (MNU)3 at 21 days of age. In this paper, the characteristics of this model are briefly reviewed and the histology of the lesions induced is presented and compared to those that occur in humans. Malignant mammary lesions induced in rats injected with MNU at 21 days of age are compared with the lesions that develop when MNU is administered to 50-day-old female rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026495322596
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