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  • 2000-2004  (3)
  • 1975-1979  (4)
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  • 1
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    Oligonucleotide probes for the identification of three algal groups by dot blot and fluorescent whole-cell hybridization (2000)
    In:  EPIC3Journal of eukaryotic microbiology, 47, pp. 76-84
    Details
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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    PAPER (OA)
  • 2
    Electronic Resource
    Electronic Resource
    Patient maintained sedation for colonoscopy using a target controlled infusion of propofol (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this study, we evaluated safety and recovery using a patient maintained, target controlled infusion of propofol for sedation in 20 patients undergoing colonoscopy. Using a handset with a two-minute lockout interval, patients could make 0.2 µg.ml−1 increments to an initial target plasma concentration of 1 µg.ml−1 up to a maximum 4.5 µg.ml−1. Four patients became oversedated but required no airway or circulatory interventions. Subjects had a significant reduction in mean (SD) heart rate: 78.7 (15) vs. 69.8 (13.5) (p 〈 0.001) and in systolic blood pressure 121.1 (13.2) mmHg vs. 96.5 (8.6) mmHg (p 〈 0.001). Choice reaction time testing 15 min after colonoscopy showed a significant median (IQR [range]) rise of 162 (− 16, 383.3 [-199–859]) ms (p 〈 0.05). Six patients had faster reaction times postcolonoscopy. All patients denied unpleasant recall and were satisfied with the system. Although oversedation was a problem in this model, we conclude that patient maintained propofol sedation could be possible for colonoscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03580.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Downregulation and altered spatial pattern of caveolin-1 in chronic plaque psoriasis (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Caveolin-1 is a key structural and functional protein for plasmalemmal invaginations termed caveolae. Caveolin-1 is known to modulate multiple signal-transducing pathways involved in cell differentiation and proliferation. Psoriasis is viewed as a multifactorial pathology characterized by keratinocyte hyperproliferation and abnormal cell maturation. We hypothesized that loss of caveolin-1 within epidermal keratinocytes may contribute to the development and/or progression of the psoriatic phenotype. Objectives To examine the expression and spatial distribution of caveolin-1 in skin biopsies from normal subjects and in patients with psoriasis. Methods Using immunohistochemical methods caveolin-1 protein expression was assayed in two independent patient groups. Firstly, a retrospective analysis was conducted on archival skin samples obtained from nine normal subjects and from involved tissue of 12 patients with psoriasis. Following this, a prospectively designed study was conducted in 10 further patients with active psoriasis and involving caveolin-1 staining of biopsy tissue from the uninvolved, advancing edge and lesional skin tissue from within the same subject. Results In normal skin or uninvolved skin from psoriasis patients intense caveolin-1 staining was present throughout full-thickness epidermis. In 20 of the 22 patient cases (combined retrospective and prospective samples) caveolin-1 protein was significantly reduced and consistently showed very weak or absent staining within the hyperproliferative basal cell layers of the psoriatic plaque (P 〈 0·002 for retrospective archival study and P 〈 0·01 for prospectively designed study). Comparisons between caveolin-1 staining in uninvolved tissue and at the advancing edge of a migrating plaque were more equivocal (P 〉 0·05). Conclusions The findings of this study are consistent with a downregulation of caveolin-1 that may serve as an aetiological factor in the development and/or progression of psoriasis. Further mechanistic investigations are required with the potential that caveolin-1 protein may be a novel target for therapy of psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.05009.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hormonal responses to insulin infusion in diabetes mellitus (1979)
    Springer
    Diabetologia 16 (1979), S. 359-364 
    Details
    ISSN: 1432-0428
    Keywords: Low dose insulin infusion ; blood glucose ; glucagon ; cortisol ; growth hormone ; autonomic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty diabetic patients and fourteen normal volunteers received infusion of 2.4 U neutral porcine insulin/h until either the blood glucose level was stable, or until hypoglycaemia occurred. As previously reported [1] in the normal group the blood glucose stabilised at 2.8±0.1 mmol/l without any hypoglycaemic symptoms. There was an increase in blood levels of glucagon, cortisol and growth hormone as the blood glucose level fell, the mean peak increments being 167±33 pg/ml, 400±71 nmol/l and 29±7 mU/l, respectively. In ten of the diabetic subjects (Group A) the blood glucose level stabilised at 3.6±0.2 mmol/l during the insulin infusion, with peak increments in plasma glucagon (110±24pg/ml), cortisol (411±71 nmol/l) and growth hormone (22±6 mU/l), not significantly different from those in the normal subjects. These rises in hormone levels occurred during the last hour of infusion after normoglycaemia was reached and maintained. The ten remaining diabetics (Group B) developed symptoms of hypoglycaemia during the infusion. The peak increments in plasma glucagon (19±7 pg/ml), cortisol (183±36 nmol/l) and growth hormone (6±2 mU/l) in this latter group were significantly less than those in the other diabetic group or the normals. The absence of counter-regulatory hormonal responses in the Group B diabetics was related to the development of hypoglycaemia and may be the result of a dysfunction of hypothalamic gluco-regulatory centres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01223155
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Dissipation and oscillations in the flow of the saturated He II film (1976)
    Springer
    Journal of low temperature physics 24 (1976), S. 527-561 
    Details
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The response of the superfluid film velocityv to varying driving force is measured from 1 to 2.12 K using gravitational film flow between bulk reservoirs. Data on the reservoir level vs. time are analyzed and compared with four intrinsic dissipation models and can be best fit, to within 0.5%, by the formdv/dt∝−ν(T) exp [−v b (T)/v], where ν(T) andv b (T) are phenomenological parameters. Previous intrinsic dissipation measurements are critically reviewed. New indirect evidence for kinetic thinning of the film is found in 0.5% distortions in the thermally damped oscillations of the reservoir levels. Topics in potential flow damping are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00657166
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The response of plant mitochondria to media of high solute content (1976)
    Springer
    Journal of bioenergetics and biomembranes 8 (1976), S. 121-129 
    Details
    ISSN: 1573-6881
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The state-3 rate of respiration of potato tuber mitochondria is inhibited by concentrations of KCl or NaCl above 125 mM, and by concentrations of sucrose, lactose, or maltose above 500 mM, but not at all by mannitol, glucose, glycine, or proline up to a concentration of 1500 mM in the medium. Mitochondria from cauliflower, beetroot, cucumber, rock melon, and watermelon behave very similarly to those from potato tuber. The variable response to different solutes proves that the reduction in respiration is not a simple function of the chemical potential of water in the medium. Disruption of potato mitochondria by ultrasonic vibration does not relieve the inhibition of succinate oxidation caused by KCl or sucrose. However, treatment with detergent abolishes completely the inhibition of respiration by sucrose. Inhibition of succinate dehydrogenase [Succinate:PMS, oxidoreductase (EC.1.3.99.1)] and malate dehydrogenase [L-Malate:NAD oxidoreductase (EC.1.1.1.37)] activities by sucrose is less than the inhibition of succinate- and malate-dependent oxygen uptake by the potato mitochondria. Limited substrate uptake and, alternatively, reduced electron flow as a consequence of a direct effect of solute on the mitochondrial membrane are considered as possible mechanisms of inhibition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00748958
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Factors limiting mitochondrial respiration in media of high solute content (1975)
    Springer
    Journal of bioenergetics and biomembranes 7 (1975), S. 189-200 
    Details
    ISSN: 1573-6881
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The state-3 rate of respiration of rat-liver mitochondria was depressed in media containing KCl, sucrose, or mannitol at concentrations in excess of 125 mM. At equivalent concentrations, glucose caused less inhibition than sucrose or mannitol, and no inhibition was observed with glycine. These observations establish that solute inhibition of respiration is not a consequence of the reduced chemical potential of water in the system. The accumulation of succinate by mitochondria was not reduced by high sucrose concentrations. Sonication only partially relieved inhibition by sucrose or mannitol, and not at all that by KCl, and the evidence indicates that solute inhibition is not primarily an inhibition of substrate entry into mitochondria. Sucrose in the assay media inhibited succinate dehydrogenase [succinate: PMS oxidoreductase (EC.1. 3. 91)] and malate dehydrogenase [l-malate: NAD oxidoreductase (EC.1.1.1.37)] activities, but these inhibitions were less than those of succinate-and malate-dependent oxygen uptake by mitochondria. Disruption of the mitochondrial membrane by detergent abolished the inhibition of respiration by sucrose, and the evidence indicates that solute inhibits the functional capacity of the membrane-associated respiratory system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01558547
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    Paper (German National Licenses)
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