Note: Front Cover -- International Review of Neurobiology -- Copyright Page -- Contents -- Contents of Volumes 1-25 -- Subject Index -- Contributor Index.

Note: Front Cover -- International Review of Neurobiology -- Copyright Page -- Contents -- Contributors -- Chapter 1. Unique General Anesthetic Binding Sites Within Distinct Conformational States of the Nicotinic Acetylcholine Receptor -- I. Introduction -- II. General Anesthetics -- III. The Ligand-Gated Ion Channel Receptor Superfamily -- IV. General Anesthetic Binding Sites -- V. Possible Caveats -- VI. Future Directions -- References -- Chapter 2. Signaling Molecules and Receptor Transduction Cascades That Regulate NMDA Receptor-Mediated Synaptic Transmission -- I. Excitatory Synaptic Transmission -- II. General Information About NMDARs -- III. Signaling Molecules and Their Regulation of NMDA Channels -- IV. Trafficking of Glutamate Receptors -- V. General Information on GPCRs -- VI. Receptor Tyrosine Kinases -- VII. Concluding Remarks -- References -- Chapter 3. Behavioral Measures of Alcohol Self-Administration and Intake Control: Rodent Models -- I. Introduction -- II. Background -- III. Methods to Measure Ethanol-Seeking in Rodents -- IV. Conclusions -- References -- Chapter 4. Dopaminergic Mouse Mutants: Investigating the Roles of the Different Dopamine Receptor Subtypes and the Dopamine Transporter -- I. Dopamine and Its Receptors -- II. History of the Dopamine Receptors -- III. D1-Like Receptors -- IV. D2-Like Receptors -- V. Double Knockout Models -- VI. Dopamine Transporter -- VII. Discussion -- References -- Chapter 5. Drosophila melanogaster, A Genetic Model System for Alcohol Research -- I. Introduction -- II. Ethanol Metabolism -- III. Ethanol Toxicity -- IV. Acute Ethanol Intoxication -- V. Ethanol Tolerance -- VI. Ethanol Preference -- VII. Conclusions -- References -- Index -- Contents of Recent Volumes.

Note: Front Cover -- International Review of Neurobiology -- Copyright Page -- CONTENTS -- CONTRIBUTORS -- Chapter 1. Behavioral Mechanisms and the Neurobiology of Conditioned Sexual Responding -- I. Introduction -- II. Pavlovian Conditioning of Sexual Responses -- III. Hormones and Sexual Conditioning -- IV. Sexual Conditioning and the Brain -- V. Behavior Systems and Biological Constraints on Learning -- VI. Conditioning and the Sexual Behavior System of Quail: The Role of Species-typical Cues -- VII. Pavlovian Conditioning and Reproductive Success -- VIII. Conclusions -- References -- Chapter 2. NMDA Receptors in Alcoholism -- I. Alcohol Dependence -- II. The NMDA Receptor -- III. Acute Effect of Ethanol on the NMDA Receptor -- IV. Role of the NMDA Receptor in the Perception of Ethanol's Effects -- V. Role of the NMDA Receptor in Adaptation to Ethanol -- VI. The NMDA Receptor and Pharmacotherapy of Alcohol Dependence -- VII. Conclusions -- References -- Chapter 3. Processing and Representation of Species-Specific Communication Calls in the Auditory System of Bats -- I. Introduction -- II. General Features of the Mammalian Auditory System -- III. The Structure of Communication Calls Emitted by Mexican Free-tailed Bats -- IV. Processing and Representation of Communication Sounds in a Lower Auditory Nucleus -- V. The Population of DNLL Neurons Reproduce the Spectral and Temporal Features of any Complex Signal -- VI. Processing and Representation of Communication Sounds is More Complex in the Inferior Colliculus -- VII. Progressive Transformations Occur along the Auditory Pathway but are Scrambled in the IC -- VIII. Due to Selectivity, Each Call is Coded in the Inferior Colliculus by a Unique Population Response -- IX. Processing in the Cortex -- X. The Biosonar Calls of the Mustache Bat -- XI. The Auditory Cortex of the Mustache Bat. , XII. The Mustache Bat Auditory Cortex is Well Adapted for Processing Both Biosonar and Communication Calls -- XIII. Structure of the Mustache Bats' Social Communication Calls -- XIV. Responses of FM-FM Neurons in the Mustache Bat Cortex to Social Communication Calls -- XV. Is Combinatorial Sensitivity an Emergent Property in the Forebrain of Vertebrates? -- XVI. Mechanisms that Generate Combination Sensitivity -- XVII. Implications for Hierarchical Processing -- XVIII. Concluding Comments -- References -- Chapter 4. Central Nervous System Control of Micturition -- I. Introduction -- II. Motoneurons Innervating Bladder and Urethral Sphincter -- III. Sacral Cord Micturition Reflexes -- IV. Brainstem-Spinal Cord Pathways Coordinate Bladder and Sphincter Motoneurons -- V. Afferent Systems of the M-region -- VI. Conclusions -- References -- Chapter 5. The Structure and Physiology of the Rat Auditory System: An Overview -- I. Introduction -- II. The Cochlear Nuclear Complex -- III. The Superior Olivary Complex -- IV. The Nuclei of the Lateral Lemniscus -- V. The Inferior Colliculus -- VI. The Medial Geniculate Body -- VII. The Auditory Cortex -- VIII. The Descending Auditory Pathway -- IX. Concluding Remarks -- X. Acknowledgments -- References -- Chapter 6. Neurobiology of Cat and Human Sexual Behavior -- I. The Spino-Brainstem-Spinal Circuit for the Mating Reflex in Cat -- II. Central Control of Mating Behavior in Humans -- III. Differences in Central Nervous System Control of Sexual Behavior Between Rodents and Primates -- References -- INDEX -- CONTENTS OF RECENT VOLUMES -- Color Plate Section.

Note: Cover -- Contents -- Contributors -- Chapter 1. GABAA Receptor Structure-Function Studies: A Reexamination in Light of New Acetylcholine Receptor Structures -- I. Overview -- II. Subunits, Cloning, Topology, and Assembly -- III. Receptor Kinetics -- IV. Channel Characteristics. Selectivity and Conductance -- V. SCAM and Channel Structure-Function Relationships -- VI. Overview of High-Resolution Structures of the Homologous ACh Receptor -- VII. The Membrane-Spanning Domain Structure -- VIII. AChBP Structure and the GABA Binding Sites -- IX. The Interface Between the Extracellular and Membrane-Spanning Domains: How Does Transduction Work? -- X. Conclusions -- References -- Chapter 2. Dopamine Mechanisms and Cocaine Reward -- I. Introduction -- II. Basic Pharmacology of Cocaine -- III. Monoamine Transporters -- IV. Nucleus Accumbens Dopamine -- V. Prefrontal Cortex Dopamine -- VI. Midbrain Dopamine Neurons -- VII. Phasic and Tonic Dopamine Release -- VIII. Dopamine Receptors -- IX. Striatal Medium Spiny Neurons -- X. Dopamine and Intracellular Cascades -- XI. Neural Basis of Associative Learning -- XII. Midbrain Dopamine Neurons and Associative Learning -- XIII. Drug Addiction and Learning -- XIV. Cocaine-Associative Learning -- XV. Summary -- References -- Chapter 3. Proteolytic Dysfunction in Neurodegenerative Disorders -- I. Introduction -- II. Proteolysis in the Central Nervous System -- III. Parkinson's Disease -- IV. Alzheimer's Disease -- V. Amyotrophic Lateral Sclerosis -- VI. Polyglutamine Repeat Diseases -- VII. Prion Diseases -- VIII. Conclusion -- References -- Chapter 4. Neuroimaging Studies in Bipolar Children and Adolescents -- I. Introduction -- II. Background -- III. Methodology -- IV. Neuropsychological Abnormalities in Bipolar Disorder -- V. Brain Imaging Findings in Adult Patients. , VI. Brain Imaging Findings in Children and Adolescents -- VII. Summary -- References -- Chapter 5. Chemosensory G-Protein-Coupled Receptor Signaling in the Brain -- I. Introduction -- II. Chemosensing G-Protein-Coupled Receptors in the Brain -- References -- Chapter 6. Disturbances of Emotion Regulation after Focal Brain Lesions -- I. Definitions -- II. The Neuroanatomy of Emotions and Feelings -- III. Disturbances of Emotional Experience After Focal Brain Damage -- IV. Developmental Versus Adult-Onset Brain Damage -- V. Neural Mechanisms of Emotional Control -- VI. Emotion, Cognition, and Social Behavior -- VII. Conclusion -- References -- Chapter 7. The Use of Caenorhabditis elegans in Molecular Neuropharmacology -- I. Ivermectin -- II. Fluoxetine -- III. Alcohol -- References -- Index -- Contents of Recent Volumes.

Note: Nuclear Magnetic Resonance -- Contents -- Chapter 1 Nuclear Shielding -- 1 Introduction -- 2 Basic Aspects of Nuclear Shielding -- A General Theory -- B Basic Physical Aspects -- 3 Calculations of Nuclear Shielding -- A Introduction -- B Ab Initio Calculations -- C Empirical and Semi-empirical Calculations -- 4 Transmission of Effects within Molecules -- A Introduction -- B 'Resonance Effects', 'Inductive Effects', and 'Substituent Effects' in General -- C Magnetic Anisotropy Effects -- E Electric Field Effects -- F van der Waals and Steric Effects -- G Hydrogen Bonding Effects -- H Isotope Shifts -- 5 Shielding of Particular Nuclear Species -- A Introduction -- B Fluorine Chemical Shifts -- C Phosphorus Chemical Shifts -- D Boron Chemical Shifts -- E Silicon Chemical Shifts -- F Nitrogen Chemical Shifts -- G Chemical Shifts of other Nuclei -- 6 Conclusions -- Chapter2 Nuclear Spin-Spin Coupling -- 1 Introduction -- 2 Theoretical Work -- A Ab Initio Calculations -- B Semi-empirical Calculations -- C Other Topics of Theoretical Interest -- 3 Coupling of Directly Bonded Nuclei -- A Coupling to Hydrogen -- B Coupling to Elements of Groups IIIB and IVB -- C Coupling to Elements of Group VB -- D Coupling to Elements of Group VIB -- E Coupling to Elements of Group VIIB -- F Miscellaneous One-bond Couplings -- 4 Coupling between Nuclei Separated by Two Chemical Bonds, 2J -- A Geminal Proton-Proton Coupling -- B Two-bond Coupling of Other Nuclei to Protons -- C Two-bond Coupling to Carbon, Excluding 2J(13CX1H) -- D 2J(31P,29Si) -- E Coupling of Group VB and VIIB Elements to Group VB -- F Two-bond (19F,19F) Coupling -- G Miscellaneous Two-bond Couplings -- 5 Coupling between Nuclei Separated by Three Chemical Bonds, 3J -- A Vicinal Proton-Proton Coupling via Carbon 3J(1HCC1H) -- B Three-bond coupling of Protons via Other Atoms. , C Three-bond Coupling of Other Nuclei to Protons -- D Three-bond Coupling to Carbon -- E Three-bond Coupling to Phosphorus -- F Three-bond Coupling to Fluorine -- 6 Coupling between Nuclei Separated by Four Chemical Bonds, 4J -- A Proton-Proton Coupling via Carbon, 4J(1HCCC1H) -- B Four-bond Coupling of Protons via Other Atoms -- C Four-bond Coupling of Other Nuclei to Protons -- D Four-bond Coupling to Carbon -- E Four-bond Coupling to Fluorine -- A Proton-ProtonCoupling via Carbon,5J(1HCCCC1H) -- B Five-bond Proton-Proton Coupling via Other Atoms -- C Five-bond Coupling of Other Nuclei to Protons -- D Five-bond Coupling to Carbon -- E Five-bond (19F,19F) Coupling -- F 5J(195PtSiCCC19F) -- G Other Five-bond Couplings -- 8 Coupling between Nuclei Separated by Six Chemical Bonds,6J -- A Proton-Proton Coupling via Carbon, 6J(1HCCCCC1H) -- B Proton-Proton Coupling via Other Atoms -- C Six-bond Coupling of Other Nuclei to Protons -- 9 Coupling between Nuclei Separated by Seven or More Chemical Bonds -- A 7J(lH,1H) -- B 9J(1HCCCCCCCC1H) -- C nJ(19F,19F) -- n = 9-14 -- 10 Coupling in π-Electron Systems -- A Homo-aromatic Molecules -- B Annulenes -- C Heterocyclic Molecules -- D Linear Molecules -- 11 Through-space Coupling -- 12 Recent Experimental Advances -- Chapter3 Nuclear Spin Relaxation in Liquids -- 1 Introduction -- 2 Models for Molecular Rotation -- 3 Relaxation Studies in Pure Liquids -- A Proton and Deuteron Relaxation -- B 13C Relaxation -- C 29Si Relaxation -- D 207Pb Relaxation -- E Studies of Several Resonant Nuclei: 1H, 2H, 14N, 19F, 35Cl -- 4 Relaxation Studies in Liquid Mixtures of Non-electrolytes -- A Proton and Deuteron Relaxation -- B 13C Relaxation -- C Studies of Several Resonant Nuclei: 1H, 2H, 14N, 19F -- 5 Relaxation Studies in Electrolyte Solutions -- A Proton Relaxation -- B 13C Relaxation. , C Relaxation of Heavy Spin-1/2 Nuclei: 113Cd, 199Hg, 205Tl, 207Pb -- D Relaxation of Alkali-metal and Halogen Nuclei: 7Li, 23Na, 85Rb, 87Rb, 133Cs, 19F, 35Cl, 37Cl, 79Br, 81Br, 127I -- Chapter 4 Bandshape Phenomena in Liquids -- 1 Introduction -- A Recent Developments -- B Coverage of the Report -- 2 Experimental Aspects -- A Fourier Transform versus Continuous Wave Spectra -- B Resolution Enhancement -- C Magnetic Field Inhomogeneities -- 3 Exchange of Magnetic Sites -- A General Aspects -- B Intramolecular Exchange -- C Intermolecular Exchange -- D Mechanistic Studies in Inorganic Chemistry -- 4 Relaxation Effects: Linewidths -- A Theoretical Work -- B Chemical Exchange Rates Determined by the Swift-Connick Approach -- C Linewidth Determinations in Paramagnetic Systems -- D Effects of Scalar Coupling to Quadrupolar Nuclei -- Chapter5 Multiple Resonance -- 1 Introduction -- 2 Theory of Multiple Resonance -- 3 Experimental Techniques -- 4 The Nuclear Overhauser Effect -- A Intramolecular -- B Intermolecular -- 5 Chemical Applications of Multiple Resonance -- A Decoupling: Simplification and Assignment -- B Selective Irradiation Experiments: Measurements of Magnitudes and Relative Signs of Coupling Constants -- C Chemical Shift Determination -- 6 Solid-state Studies -- Chapter6 Macromolecules -- 1 Introduction -- 2 Reviews -- 3 Synthetic Macromolecules -- A 1H High-resolution N.M.R. -- B Broadline N.M.R. -- C Spin-echo N.M.R. -- D 13C N.M.R. -- E 19F N.M.R. -- 4 Biological and Related Macromolecules -- A 1H N.M.R. of Synthetic Polypeptides -- B 1H N.M.R. of Natural and Related Polypeptides and Polysaccharides -- C 1H N.M.R. of Proteins -- D 1H N.M.R. of Enzymes -- E 1H N.M.R. of Polynucleotides -- F 13C Studies -- G Other Nuclei -- 5 Small Molecules -- A 1H Studies of Hydration -- B 1H N.M.R.- General Studies -- C 13C N.M.R. Studies -- D Other Nuclei. , E Counter-ion N.M.R. -- Chapter 7 Liquid Crystals and Micellar Solutions -- 1 Introduction -- 2 Reviews -- 3 Lyotropic Liquid Crystal Phases -- A Alkyl-chain Resonances -- B Water Studies -- C Counter-ion Studies -- D Vesicle Studies -- 4 Thermotropic Liquid Crystals -- 5 Micelles -- 6 Reversed Micelles -- 7 Microemulsions and Emulsions -- Chapter 8 The Solid State -- 1 General Introduction -- 2 Half-integral Spins in Diamagnetic Solids -- A Introduction -- B Theory of the Resonance Spectrum -- C Nuclear Spin-Lattice Relaxation Theory -- D Structural Studies -- E Motional Studies (Classical Regime) -- F Quantum Effects -- G High Resolution in Solids -- H N.M.R. Image Formation -- A Introduction -- B 2H N.M.R. -- C First-row Elements -- D Second-row Elements -- E Other Nuclei -- 4 Systems with Unpaired Electrons in the Absence of Magnetic Ordering -- A Non-metallic Paramagnetic Systems -- B Metals -- C Alloys -- D Semiconductors -- E Metal Hydrides -- F One-dimensional Metals -- 5 Ordered Magnetic Materials -- A Ferromagnetic Materials -- B Antiferromagnetic Materials -- C Ferrimagnetic Materials -- 6 New Apparatus and Techniques -- A Techniques -- B Analysis -- C Sources of Error -- D Apparatus -- 7 Surface Phenomena -- A Introduction -- B Adsorption on Graphite and Charcoal -- C Adsorption on Silica -- D Adsorption on Aluminas and other Surfaces -- E Zeolites -- Chapter 9 Medium Effects -- 1 Introduction -- 2 Non-specific Medium Effects -- 3 Effects due to Specific Interactions with the Medium -- A The ASIS Effect -- B Hydrogen-bonded Systems -- C Aqueous Systems -- D Ionic Solutions -- E Micellar Aggregation -- 4 Shift Reagents -- Author Index.

Note: Front Cover -- Cell Growth and Cell Division -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS -- PREFACE -- Chapter 1. INDEPENDENT CYCLES OF CELL DIVISION AND OF DNA SYNTHESIS IN TETRAHYMENA -- INTRODUCTION -- THE PROBLEM -- RNA SYNTHESIS AND SYNCHRONOUS DIVISION -- ASYNCHRONOUS DNA SYNTHESIS AND SYNCHRONOUS DIVISION -- DISCUSSION -- SUMMARY -- REFERENCES -- Chapter 2. CELL DIVISION AND GROWTH STUDIES ON SYNCHRONIZED FLAGELLATES1 -- INTRODUCTION -- CONTINUOUS SYNCHRONIZED CULTURES -- OXYGEN CONSUMPTION DURING DIVISION -- STRUCTURES IN ASTASIA -- CELL DIVISION -- CELL FISSION AND THE CELL SURFACE -- SUMMARY -- REFERENCES -- Chapter 3. MACRONUCLEAR VARIABILITY OF BLEPHARISMA ASSOCIATED WITH GROWTH -- INTRODUCTION -- SPECIES AND STRAINS USED IN THIS STUDY -- NUTRITIONAL STUDIES -- TEMPERATURE STUDIES -- PRESSURE STUDIES -- STUDIES OF BLEPHARISMA GROWTH -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4. FACETS OF INTRACELLULAR REGULATION OF MEIOSIS AND MITOSIS -- INTRODUCTION -- EXPERIMENTAL STUDIES -- THE MEIOTIC CYCLE IN TRILLIUM ERECTUM -- DEVELOPMENTAL STAGE AND SUSCEPTIBILITY TO INHIBITION -- NATURE OF UPSETS IN THE MEIOTIC CYCLE -- UPSET OF MEIOSIS I -- UPSET OF MEIOSIS II -- CHROMOSOME STRUCTURE -- AUTONOMY AT THE MOLECULAR LEVEL -- SUMMARY -- REFERENCES -- Chapter 5. NUCLEOTIDE METABOLISM AND RIBOSOMAL ACTIVITY DURING SYNCHRONIZED CELL DIVISION -- INTRODUCTION -- RESULTS AND DISCUSSION -- CONCLUSIONS -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 6. THE INTEGRATION OF PROTEIN AND RIBONUCLEIC ACID SYNTHESIS IN BACTERIA -- INTRODUCTION -- RACKGROUND -- RIBOSOMAL AND TRANSFER RNA -- THE CONTROL OF RNA SYNTHESIS -- OUTLOOK -- SUMMARY -- REFERENCES -- Chapter 7. RNA AND PROTEIN REPLACEMENT IN THE NUCLEUS DURING GROWTH AND DIVISION AND THE CONSERVATION OF COMPONENTS IN THE CHROMOSOME -- INTRODUCTION. , MATERIALS AND METHODS -- RESULTS -- SUMMARY -- REFERENCES -- Chapter 8. RNA AND PROTEIN IN NUCLEOCYTOPLASMIC INTERACTIONS1 -- RNA IN NUCLEOCYTOPLASMIC COMMUNICATION -- PROTEIN IN NUCLEOCYTOPLASMIC INTERACTIONS -- SUMMARY -- REFERENCES -- Chapter 9. THE CELL CYCLE OF A FISSION YEAST -- SUMMARY -- REFERENCES -- Chapter 10. CONTROL MECHANISMS FOR CHROMOSOME REPRODUCTION IN THE CELL CYCLE -- INTRODUCTION -- LEVELS OF OPERATION OF CONTROL MECHANISMS -- PATTERNS OF CONTROL IN REPLICATION OF CHROMOSOMAL DNA -- SUMMARY -- REFERENCES -- Chapter 11. LES FACTEURS DE LA CROISSANCE DE TUMEURS ASSOCIÉES Á DES ORGANES EMBRYONNAIRES DE POULET -- CULTURES DE TUMEURS ANIMALES ET DE SOUCHES CELLULAIRES D'ORIGINES DIVERSES -- CULTURES DE TUMEURS HUMAINES FRAÎCHES -- CONCLUSIONS -- RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 12. DYNAMISME DE L'ANA-TELOPHASE ET CYTODIÉRÈSE -- INTRODUCTION -- DIVISION NORMALE DE L'OEUF D'ARTEMIA -- DIVISION DES OEUFS ACTIVES -- INFLUENCE DES RÉACTIFS DES PROTÉINES SULFHYDRILEES SUR LA DIVISION -- CONCLUSION -- RESUME -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 13. SOME OBSERVATIONS CONCERNING CELL MOVEMENT AND CELL CLEAVAGE -- SUMMARY -- REFERENCES -- Chapter 14. A NEW THEORY ON THE MECHANISM OF CELL DIVISION -- INTRODUCTION -- METHODS USED -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 15. FORCE OF CLEAVAGE OF THE DIVIDING SEA URCHIN EGG -- INTRODUCTION -- PART I -- PART II -- PART III -- CONCLUSION -- SUMMARY -- REFERENCES -- Chapter 16. SOME PROBLEMS OF CLEAVAGE IN RELATION TO THE CELL MEMBRANE -- INTRODUCTION -- THE RELATION BETWEEN THE MITOTIC APPARATUS AND CLEAVAGE -- THE CHANGES IN THE CELL MEMBRANE DURING CLEAVAGE -- THE BIOCHEMICAL BASIS OF CLEAVAGE -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 17. APPLICATION DE TECHNIQUES CYTOLOGIQUES MODERNES À L'ÉTUDE DU PROBLÈME DES AMITOSES DANS LES BOURGEONS MUSCULAIRES. , MATÉRIEL ET TECHNIQUES -- OBSERVATIONS PERSONNELLES -- CONCLUSIONS GÉNÉRALES ET RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 18. LE PROBLÈME DE L'AMITOSE -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 19. CYTOPLASMIC DEOXYRIBONUCLEIC ACIDS: THEIR MITOCHONDRIAL LOCALIZATION AND SYNTHESIS IN SOMATIC CELLS UNDER EXPERIMENTAL CONDITIONS AND DURING THE NORMAL CELL CYCLE IN RELATION TO THE PREPARATION FOR MITOSIS -- INTRODUCTION -- POSITIVE FEULGEN REACTION IN THE CYTOPLASM -- QUANTITATIVE ESTIMATIONS OF DNA -- THE CYTOPLASMIC DNA IS CONFINED TO MODIFIED MITOCHONDRIA -- HISTORADIOAUTOGRAPHIC OBSERVATIONS -- REVERSIBILITY OF THE EFFECTS OF THE ACID DNASE -- OTHER EXPERIMENTAL PROCEDURES THAT CAUSE CYTOPLASMIC DNA -- HYPOTHESES AND SUGGESTIONS CONCERNING THE DNA LOCALIZATION AND SYNTHESIS INSIDE THE CYTOPLASM -- SUMMARY -- REFERENCES -- AUTHOR INDEX.

Note: Front Cover -- The Interpretation of Ultrastructure -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS -- PREFACE -- CHAPTER 1. CHEMICAL FIXATIVES FOR ELECTRON MICROSCOPY -- CONCLUSIONS -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION -- CHAPTER 2. WATER-SOLUBLE EMBEDDING MEDIA FOR ULTRASTRUCTURAL CYTOCHEMISTRY -- INTRODUCTION -- MATERIALS AND METHODS -- OBSERVATIONS -- DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION -- CHAPTER 3. CRITICAL EVALUATION OF ULTRASTRUCTURAL PATTERNS WITH RESPECT TO FIXATION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 4. INTERPRETATION OF ULTRASTRUCTURE IN THE CELL NUCLEUS -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION -- CHAPTER 5. CORRELATION OF ELECTRON MICROSCOPE AND X-RAY DIFFRACTION DATA IN ULTRASTRUCTURE STUDIES OF LIPOPROTEIN MEMBRANE SYSTEMS -- SUMMARY -- REFERENCES -- CHAPTER 6. QUANTITATIVE ELECTRON MICROSCOPY -- INTRODUCTION -- DISCUSSION -- SUMMARY -- REFERENCES -- CHAPTER 7. CYTOLOGY AND MICROCYTOLOGY OF LIVING AND FIXED CYTOPLASMIC CONSTITUENTS IN THE EGGS OF TUBIFEX AND THE CELL OF AMOBEA PROTEUS -- INTRODUCTION -- SUMMARY -- REFERENCES -- CHAPTER 8. LIGHT AND ELECTRON MICROSCOPIC STUDY OF MEMBRANOUS CYTOPLASMIC ORGANELLES -- INTRODUCTION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 9. NUCLEOSIDEPHOSPHATASE ACTIVITIES OF CYTOMEMBRANES -- CYTOCHEMICAL METHODS FOR ENZYME ACTIVITIES: MICROSCOPIC BIOCHEMISTRY -- PLASMA MEMBRANE -- ENDOPLASMIC RETICULUM -- THE GOLGI APPARATUS -- GOLGI APPARATUS AND LYSOSOMES -- SECRETORY GRANULES AND LYSOSOMES -- POSSIBLE ROLES OF NUCLEOSIDEPHOSPHATASES IN CYTOMEMBRANES -- POSSIBLE FUNCTIONAL SIGNIFICANCE OF THE INTIMATE TOPOGRAPHICAL RELATION BETWEEN LYSOSOMES AND GOLGI LAMELLAE -- DYNAMIC STEADY STATE: MEMBRANE FLOW IN ENDOPLASMIC RETICULUM, GOLGI APPARATUS AND LYSOSOMES. , CONCLUDING REMARKS -- SUMMARY -- REFERENCES -- CHAPTER 10. COMBINATION OF CYTOCHEMICAL STAINING METHODS FOR ENZYME LOCALIZATION WITH ELECTRON MICROSCOPY -- SUMMARY -- REFERENCES -- CHAPTER 11. NUCLEOPROTEIN LOCALIZATION IN ELECTRON MICROGRAPHS: METAL BINDING AND RADIOAUTOGRAPHY -- INTRODUCTION -- MATERIALS AND METHODS -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES -- CHAPTER 12. THE STUDY OF NATURAL AND ARTIFICIAL DNA-PLASMS BY THIN SECTIONS -- INTRODUCTION -- CONCLUSIONS AND DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES FOR THE DISCUSSION -- CHAPTER 13. NEGATIVE STAINING AND ITS USE IN THE STUDY OF VIRUSES AND THEIR SEROLOGICAL REACTIONS -- RESOLUTION AND CONTRAST -- INCREASING INSTRUMENTAL RESOLUTION BY SHADOWCASTING -- INCREASING RESOLUTION OF SPECIMEN PREPARATION -- NEGATIVE STAINING IN THEORY AND PRACTICE -- RESULTS AND DISCUSSION -- SUMMARY -- REFERENCES -- CHAPTER 14. AN ASSESSMENT OF NEGATIVE STAINING TECHNIQUES FOR REVEALING ULTRASTRUCTURE -- INTRODUCTION -- THE THEORY OF NEGATIVE STAINING -- THE PROPERTIES OF A GOOD NEGATIVE STAIN -- EXPERIMENTAL INVESTIGATION OF VARIOUS NEGATIVE STAINS -- THE BEST MATERIAL FOR A NEGATIVE STAIN -- CONTRAST LIMIT OF NEGATIVE STAINING -- STRUCTURES NOT SHOWN BY NEGATIVE STAINING -- STRUCTURAL SUBUNITS SHOWN BY NEGATIVE STAINING -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 15. THE FINER STRUCTURE OF THE MITOTIC APPARATUS -- INTRODUCTION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 16. INTERPRETATION OF THE ULTRATEXTURE IN GROWING PLANT CELL WALLS -- INTRODUCTION -- ULTRATEXTURES OF PRIMARY CELL WALLS -- THEORIES OF PASSIVE ORIENTATION -- ACTIVE ORIENTATION -- SUMMARY -- REFERENCES -- CHAPTER 17. THE ELECTRON MICROSCOPY AND ELECTRON DIFFRACTION ANALYSIS OF NATURAL CELLULOSE -- INTRODUCTION -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION. , CHAPTER 18. THE MOLECULAR STRUCTURE OF LIPID-WATER SYSTEMS AND CELL MEMBRANE MODELS STUDIED WITH THE ELECTRON MICROSCOPE -- INTRODUCTION -- RESULTS AND DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 19. THE EVOLUTION OF INTRACELLULAR PHOSPHOLIPID MEMBRANE SYSTEMS -- SUMMARY -- REFERENCES -- CHAPTER 20. RECOVERY OF VIRUS FROM THE BLOOD OF RATS WITH INDUCED LEUKAEMIA -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 21. ELECTRON MICROSCOPY IN THE STUDY OF EMBRYONIC DIFFERENTIATION -- INTRODUCTION -- CYTOPLASMIC ARCHITECTURE AND DEVELOPMENTAL CAPACITIES IN EGGS AND EMBRYONIC CELLS -- ULTRASTRUCTURAL CHARACTERISTICS AS RELATED TO DETERMINATIVE EVENTS IN DEVELOPMENT -- CONCLUDING REMARKS -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 22. NEW APPROACHES IN THE STUDY OF BIOLOGICAL ULTRASTRUCTURE BY HIGH-RESOLUTI ON ELECTRON MICROSCOPY -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- AUTHOR INDEX.

Note: Cover -- International Review of Neurobiology -- Copyright -- Contents -- Contents of Volumes 26-50 -- Volume 26 -- Volume 27 -- Volume 28 -- Volume 29 -- Volume 30 -- Volume 31 -- Volume 32 -- Volume 33 -- Volume 34 -- Volume 35 -- Volume 36 -- Volume 37 -- Volume 38 -- Volume 39 -- Volume 40 -- Volume 41 -- Volume 42 -- Volume 43 -- Volume 44 -- Volume 45 -- Volume 46 -- Volume 47 -- Volume 48 -- Volume 49 -- Volume 50 -- Subject Index -- Contributor Index.

Note: Front Cover -- International Review of Neurobiology -- Copyright Page -- CONTENTS -- CONTRIBUTORS -- Chapter 1. Assembly and Intracellular Trafficking of GABAA Receptors -- I. Introduction -- II. Assembly of GABAA Receptors -- III. Surface Targeting and Intracellular Sorting of GABAA Receptors -- IV. GABAA Receptor-Clustering Proteins -- V. Endocytosis and Recycling of GABAA Receptors -- References -- Chapter 2. Subcellular Localization and Regulation of GABAA Receptors and Associated Proteins -- I. Introduction -- II. Functional Significance of GABAergic Inhibition in the Brain -- III. Structural Anatomy of GABAergic Synapses -- IV. Structure of GABAA Receptors -- V. Subcellular Localization of GABAA Receptor Subtypes -- VI. Factors Implicated in Exocytosis and Endocytosis of GABAA Receptors -- VII. Synaptic Anchoring of GABAC Receptors -- VIII. GABAA Receptor-Associated Signaling Proteins -- IX. Synaptic Plasticity -- X. Concluding Remarks -- References -- Chapter 3. D1 Dopamine Receptors -- I. Introduction -- II. Localization and Function of D1-like Receptors -- III. Development of Drugs for D1-like Receptors -- IV. Therapeutic and Functional Actions of D1 Receptor Agonists and Antagonists -- V. Conclusions and Future Goals -- References -- Chapter 4. Molecular Modeling of Ligand-Gated Ion Channels: Progress and Challenges -- I. The Challenge of Modeling Transmembrane Ion Channels -- II. Overview of Molecular Modeling Principles -- III. Experimental Data: Techniques and Results -- IV. Molecular Models -- V. Summary -- References -- Chapter 5. Alzheimer's Disease: Its Diagnosis and Pathogenesis -- I. Introduction -- II. Diagnostic Issues -- III. Pathogenesis -- IV. Genetic Influences -- V. Inflammation and Anti-inflammatory Drugs -- VI. Estrogen Therapy -- VII. Vascular Pathology in AD -- References. , Chapter 6. DNA Arrays and Functional Genomics in Neurobiology -- I. Introduction -- II. DNA Array Formats and Technique -- III. Applications in Neurobiology -- IV. Caveats and Future Needs -- V. Conclusion -- References -- INDEX -- CONTENTS OF RECENT VOLUMES.

Note: Front Cover -- Biological Organization at the Cellular and Supercellular Level -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS AND PARTICIPANTS -- PREFACE -- CHAPTER 1. ELEMENTS OF REGULATORY CIRCUITS IN BACTERIA -- SUMMARY -- INTRODUCTION -- REGULATION OP ENZYMATIC ACTIVITY: ALLOSTERIC EFFECTS -- REGULATION OF PROTEIN SYNTHESIS -- REGULATION OF DNA REPLICATION: THE "REPLICON" HYPOTHESIS -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 2. THE KINETIC STRUCTURE OF ORGANISMS -- SUMMARY -- INTRODUCTION -- THE BOUNDARIES OF AN ORGANISM -- THECELLAS AN OPEN SYSTEM -- CATALYTIC CONTROL OF THE STEADY STATE -- EQUIFINALITY AND THE RECORD OF PAST EVENTS -- FLUX CONTROL AND GENETIC REDUNDANCY -- SEQUENCE INTERACTIONS -- HISTORICAL AND GENIC DETERMINATION -- CONCLUSIONS -- REFERENCES -- CHAPTER 3. STIMULATION OF THE RATE OF SYNTHESIS OF SPECIFIC MESSENGER RNA AFTER ENZYME INDUCTION IN E. COLI -- SUMMARY -- INTRODUCTION -- BASE SEQUENCE COMPLEMENTARITY WITH HOMOLOGOUS DNA REGIONS AS A BASIS FOR THE DETECTION OF SPECIFIC MESSENGER RNA -- DETECTION OF THE mRNA SPECIFICALLY RELATED TO THE "GAL" REGION -- DETECTION OF THE mRNA SPECIFICALLY RELATED TO THE "LAC" REGION -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 4. THE RELATIONSHIP OF THE HEREDITARY VIRUS OF DROSOPHILA TO ITS HOST -- SUMMARY -- REFERENCES -- CHAPTER 5. RELATIONSHIP BETWEEN CYTOPLASM AND CHROMOSOME IN THE TRANSMISSION OF MELANOTIC TUMOURS IN DROSOPHILA -- SUMMARY -- THE PHBNOTYPE AND ITS GENESIS -- TRANSMISSION OF CHARACTER -- DISCUSSION -- REFERENCES -- DISCUSSION -- CHAPTER 6. ASPECTS OF MUTUAL EXCLUSION IN TETRAHYMENA -- SUMMARY -- INTRODUCTION -- THE ORGANISM -- INTRA-LOCUS EXCLUSION -- INTER-LOCUS EXCLUSION -- INTER-ALLELIC EXCLUSION -- DISCUSSION -- REFERENCES. , CHAPTER 7. LOSS OF NUCLEAR POTENTIALITY IN THE SOMA VERSUS PRESERVATION OF NUCLEAR POTENTIALITY IN THE GERM LINE -- SUMMARY -- INTRODUCTION -- EXPERIMENT SWITH THE GALLMIDGE MAYETIOLA DESTRUCTOR (CECIDOMYIDAE) -- EXPERIMENTS WITH THE GERM LINE IN THE ANURA (AMPHIBIA ) -- EXPERIMENTS INVOLVING THE TRANSPLANTATION OF SOMATIC NUCLEI IN AMPHIBIA -- CONCLUSIONS -- REFERENCES -- CHAPTER 8. THE FOURTH MOMENT OF A CHARACTER DISTRIBUTION AS AN INDEX OF THE REGULATIVE EFFICIENCY OF THE GENETIC CODE -- SUMMARY -- I. DIFFERENCES IN KURTOSIS BETWEEN HATCHING TIME DISTRIBUTIONS IND, -- II. WHY SHOULD THE INTEGRATION OF THE GENETIC SYSTEM BE REFLECTED IN KURTOSIS? -- III. LEPTOKURTOSIS AND CHROMOSOMAL POLYMORPHISM IND -- IV. KURTOSIS AS AN INDICATION OF FITNESS -- ACKNO\VLEDGMENTS -- REFERENCES -- CHAPTER 9. ORIENTED CELL MOVEMENTS IN EMBRYOGENESIS -- SUMMARY -- INTRODUCTION -- CONTROL OF CELL MOVEMENTS -- DIRECTIONAL CONTROL -- MIGRATION OF PRECARDIAC MESODERM AS AN EXAMPLE OF CONTACT GUIDANCE -- REFERENCES -- CHAPTER 10. THE ROLE OF THE NUCLEIC ACIDS IN THE PROCESSES OF INDUCTION, REGULATION AND DIFFERENTIATION IN THE AMPHIBIAN EMBRYO AND THE UNICELLULAR ALGA, ACETABULARIA MEDITERRÁNEA -- SUMMARY -- INTRODUCTION -- EXPERIMENTAL EVIDENCE -- DISCUSSION -- ACKNOWLEDGMENT -- REFERENCES -- CHAPTER 11. THE ROLE OF REGIONAL SPECIFIC INDUCERS IN THE PRIMARY DETERMINATION AND DIFFERENTIATION OF AMPHIBIA -- SUMMARY -- INTRODUCTION -- FORMATION OF DEUTERENCEPHALIC INDUCTIONS BY CO-OPERATION OF TWO INDUCING FACTORS -- INACTIVATION OF INDUCING FACTORS B Y PROTEOLYTIC ENZYMES AND DIFFERENTIAL SENSITIVITY TO CHEMICAL AGENTS -- SPECIFIC ACTION VERSUS RELAIS-MECHANISM -- MECHANISM OF ACTION AT PRIMARY INDUCTION AND DIFFERENTIATION -- ACKNO\VLEDGMENT -- REFERENCES -- DISCUSSION -- CHAPTER 12. THE TRANSMISSION OF INFORMATION DURING PRIMARY EMBRYONIC INDUCTION -- SUMMARY. , INTRODUCTION -- THE TRANSMISSION OF INFORMATION -- THE TRANSMISSION OF MATERIALS -- THE RELEASE OF MATERIALS -- FINAL REMARKS -- REFERENCES -- DISCUSSION -- CHAPTER 13. SOME PROBLEMS OF DIFFERENTIATION AND INTEGRATION IN NEOPLASIA -- SUMMARY -- INTRODUCTION -- THE COURSE OF NEOPLASIA -- DIFFERENTIATION -- NEOPLASTIC DEVELOPMENT -- CONCLUSIONS -- REFERENCES -- CHAPTER 14. BIOLOGICAL ORGANIZATION: SUMMARIZING LECTURE -- CONCLUDING REMARKS -- REFERENCES -- Author Index.