Note: Front Cover -- Cell Growth and Cell Division -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS -- PREFACE -- Chapter 1. INDEPENDENT CYCLES OF CELL DIVISION AND OF DNA SYNTHESIS IN TETRAHYMENA -- INTRODUCTION -- THE PROBLEM -- RNA SYNTHESIS AND SYNCHRONOUS DIVISION -- ASYNCHRONOUS DNA SYNTHESIS AND SYNCHRONOUS DIVISION -- DISCUSSION -- SUMMARY -- REFERENCES -- Chapter 2. CELL DIVISION AND GROWTH STUDIES ON SYNCHRONIZED FLAGELLATES1 -- INTRODUCTION -- CONTINUOUS SYNCHRONIZED CULTURES -- OXYGEN CONSUMPTION DURING DIVISION -- STRUCTURES IN ASTASIA -- CELL DIVISION -- CELL FISSION AND THE CELL SURFACE -- SUMMARY -- REFERENCES -- Chapter 3. MACRONUCLEAR VARIABILITY OF BLEPHARISMA ASSOCIATED WITH GROWTH -- INTRODUCTION -- SPECIES AND STRAINS USED IN THIS STUDY -- NUTRITIONAL STUDIES -- TEMPERATURE STUDIES -- PRESSURE STUDIES -- STUDIES OF BLEPHARISMA GROWTH -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4. FACETS OF INTRACELLULAR REGULATION OF MEIOSIS AND MITOSIS -- INTRODUCTION -- EXPERIMENTAL STUDIES -- THE MEIOTIC CYCLE IN TRILLIUM ERECTUM -- DEVELOPMENTAL STAGE AND SUSCEPTIBILITY TO INHIBITION -- NATURE OF UPSETS IN THE MEIOTIC CYCLE -- UPSET OF MEIOSIS I -- UPSET OF MEIOSIS II -- CHROMOSOME STRUCTURE -- AUTONOMY AT THE MOLECULAR LEVEL -- SUMMARY -- REFERENCES -- Chapter 5. NUCLEOTIDE METABOLISM AND RIBOSOMAL ACTIVITY DURING SYNCHRONIZED CELL DIVISION -- INTRODUCTION -- RESULTS AND DISCUSSION -- CONCLUSIONS -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 6. THE INTEGRATION OF PROTEIN AND RIBONUCLEIC ACID SYNTHESIS IN BACTERIA -- INTRODUCTION -- RACKGROUND -- RIBOSOMAL AND TRANSFER RNA -- THE CONTROL OF RNA SYNTHESIS -- OUTLOOK -- SUMMARY -- REFERENCES -- Chapter 7. RNA AND PROTEIN REPLACEMENT IN THE NUCLEUS DURING GROWTH AND DIVISION AND THE CONSERVATION OF COMPONENTS IN THE CHROMOSOME -- INTRODUCTION. , MATERIALS AND METHODS -- RESULTS -- SUMMARY -- REFERENCES -- Chapter 8. RNA AND PROTEIN IN NUCLEOCYTOPLASMIC INTERACTIONS1 -- RNA IN NUCLEOCYTOPLASMIC COMMUNICATION -- PROTEIN IN NUCLEOCYTOPLASMIC INTERACTIONS -- SUMMARY -- REFERENCES -- Chapter 9. THE CELL CYCLE OF A FISSION YEAST -- SUMMARY -- REFERENCES -- Chapter 10. CONTROL MECHANISMS FOR CHROMOSOME REPRODUCTION IN THE CELL CYCLE -- INTRODUCTION -- LEVELS OF OPERATION OF CONTROL MECHANISMS -- PATTERNS OF CONTROL IN REPLICATION OF CHROMOSOMAL DNA -- SUMMARY -- REFERENCES -- Chapter 11. LES FACTEURS DE LA CROISSANCE DE TUMEURS ASSOCIÉES Á DES ORGANES EMBRYONNAIRES DE POULET -- CULTURES DE TUMEURS ANIMALES ET DE SOUCHES CELLULAIRES D'ORIGINES DIVERSES -- CULTURES DE TUMEURS HUMAINES FRAÎCHES -- CONCLUSIONS -- RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 12. DYNAMISME DE L'ANA-TELOPHASE ET CYTODIÉRÈSE -- INTRODUCTION -- DIVISION NORMALE DE L'OEUF D'ARTEMIA -- DIVISION DES OEUFS ACTIVES -- INFLUENCE DES RÉACTIFS DES PROTÉINES SULFHYDRILEES SUR LA DIVISION -- CONCLUSION -- RESUME -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 13. SOME OBSERVATIONS CONCERNING CELL MOVEMENT AND CELL CLEAVAGE -- SUMMARY -- REFERENCES -- Chapter 14. A NEW THEORY ON THE MECHANISM OF CELL DIVISION -- INTRODUCTION -- METHODS USED -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 15. FORCE OF CLEAVAGE OF THE DIVIDING SEA URCHIN EGG -- INTRODUCTION -- PART I -- PART II -- PART III -- CONCLUSION -- SUMMARY -- REFERENCES -- Chapter 16. SOME PROBLEMS OF CLEAVAGE IN RELATION TO THE CELL MEMBRANE -- INTRODUCTION -- THE RELATION BETWEEN THE MITOTIC APPARATUS AND CLEAVAGE -- THE CHANGES IN THE CELL MEMBRANE DURING CLEAVAGE -- THE BIOCHEMICAL BASIS OF CLEAVAGE -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 17. APPLICATION DE TECHNIQUES CYTOLOGIQUES MODERNES À L'ÉTUDE DU PROBLÈME DES AMITOSES DANS LES BOURGEONS MUSCULAIRES. , MATÉRIEL ET TECHNIQUES -- OBSERVATIONS PERSONNELLES -- CONCLUSIONS GÉNÉRALES ET RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 18. LE PROBLÈME DE L'AMITOSE -- SUMMARY -- BIBLIOGRAPHIE -- Chapter 19. CYTOPLASMIC DEOXYRIBONUCLEIC ACIDS: THEIR MITOCHONDRIAL LOCALIZATION AND SYNTHESIS IN SOMATIC CELLS UNDER EXPERIMENTAL CONDITIONS AND DURING THE NORMAL CELL CYCLE IN RELATION TO THE PREPARATION FOR MITOSIS -- INTRODUCTION -- POSITIVE FEULGEN REACTION IN THE CYTOPLASM -- QUANTITATIVE ESTIMATIONS OF DNA -- THE CYTOPLASMIC DNA IS CONFINED TO MODIFIED MITOCHONDRIA -- HISTORADIOAUTOGRAPHIC OBSERVATIONS -- REVERSIBILITY OF THE EFFECTS OF THE ACID DNASE -- OTHER EXPERIMENTAL PROCEDURES THAT CAUSE CYTOPLASMIC DNA -- HYPOTHESES AND SUGGESTIONS CONCERNING THE DNA LOCALIZATION AND SYNTHESIS INSIDE THE CYTOPLASM -- SUMMARY -- REFERENCES -- AUTHOR INDEX.

Note: Nuclear Magnetic Resonance -- Contents -- Chapter 1 Nuclear Shielding -- 1 Introduction -- 2 Basic Aspects of Nuclear Shielding -- A General Theory -- B Basic Physical Aspects -- 3 Calculations of Nuclear Shielding -- A Introduction -- B Ab Initio Calculations -- C Empirical and Semi-empirical Calculations -- 4 Transmission of Effects within Molecules -- A Introduction -- B 'Resonance Effects', 'Inductive Effects', and 'Substituent Effects' in General -- C Magnetic Anisotropy Effects -- E Electric Field Effects -- F van der Waals and Steric Effects -- G Hydrogen Bonding Effects -- H Isotope Shifts -- 5 Shielding of Particular Nuclear Species -- A Introduction -- B Fluorine Chemical Shifts -- C Phosphorus Chemical Shifts -- D Boron Chemical Shifts -- E Silicon Chemical Shifts -- F Nitrogen Chemical Shifts -- G Chemical Shifts of other Nuclei -- 6 Conclusions -- Chapter2 Nuclear Spin-Spin Coupling -- 1 Introduction -- 2 Theoretical Work -- A Ab Initio Calculations -- B Semi-empirical Calculations -- C Other Topics of Theoretical Interest -- 3 Coupling of Directly Bonded Nuclei -- A Coupling to Hydrogen -- B Coupling to Elements of Groups IIIB and IVB -- C Coupling to Elements of Group VB -- D Coupling to Elements of Group VIB -- E Coupling to Elements of Group VIIB -- F Miscellaneous One-bond Couplings -- 4 Coupling between Nuclei Separated by Two Chemical Bonds, 2J -- A Geminal Proton-Proton Coupling -- B Two-bond Coupling of Other Nuclei to Protons -- C Two-bond Coupling to Carbon, Excluding 2J(13CX1H) -- D 2J(31P,29Si) -- E Coupling of Group VB and VIIB Elements to Group VB -- F Two-bond (19F,19F) Coupling -- G Miscellaneous Two-bond Couplings -- 5 Coupling between Nuclei Separated by Three Chemical Bonds, 3J -- A Vicinal Proton-Proton Coupling via Carbon 3J(1HCC1H) -- B Three-bond coupling of Protons via Other Atoms. , C Three-bond Coupling of Other Nuclei to Protons -- D Three-bond Coupling to Carbon -- E Three-bond Coupling to Phosphorus -- F Three-bond Coupling to Fluorine -- 6 Coupling between Nuclei Separated by Four Chemical Bonds, 4J -- A Proton-Proton Coupling via Carbon, 4J(1HCCC1H) -- B Four-bond Coupling of Protons via Other Atoms -- C Four-bond Coupling of Other Nuclei to Protons -- D Four-bond Coupling to Carbon -- E Four-bond Coupling to Fluorine -- A Proton-ProtonCoupling via Carbon,5J(1HCCCC1H) -- B Five-bond Proton-Proton Coupling via Other Atoms -- C Five-bond Coupling of Other Nuclei to Protons -- D Five-bond Coupling to Carbon -- E Five-bond (19F,19F) Coupling -- F 5J(195PtSiCCC19F) -- G Other Five-bond Couplings -- 8 Coupling between Nuclei Separated by Six Chemical Bonds,6J -- A Proton-Proton Coupling via Carbon, 6J(1HCCCCC1H) -- B Proton-Proton Coupling via Other Atoms -- C Six-bond Coupling of Other Nuclei to Protons -- 9 Coupling between Nuclei Separated by Seven or More Chemical Bonds -- A 7J(lH,1H) -- B 9J(1HCCCCCCCC1H) -- C nJ(19F,19F) -- n = 9-14 -- 10 Coupling in π-Electron Systems -- A Homo-aromatic Molecules -- B Annulenes -- C Heterocyclic Molecules -- D Linear Molecules -- 11 Through-space Coupling -- 12 Recent Experimental Advances -- Chapter3 Nuclear Spin Relaxation in Liquids -- 1 Introduction -- 2 Models for Molecular Rotation -- 3 Relaxation Studies in Pure Liquids -- A Proton and Deuteron Relaxation -- B 13C Relaxation -- C 29Si Relaxation -- D 207Pb Relaxation -- E Studies of Several Resonant Nuclei: 1H, 2H, 14N, 19F, 35Cl -- 4 Relaxation Studies in Liquid Mixtures of Non-electrolytes -- A Proton and Deuteron Relaxation -- B 13C Relaxation -- C Studies of Several Resonant Nuclei: 1H, 2H, 14N, 19F -- 5 Relaxation Studies in Electrolyte Solutions -- A Proton Relaxation -- B 13C Relaxation. , C Relaxation of Heavy Spin-1/2 Nuclei: 113Cd, 199Hg, 205Tl, 207Pb -- D Relaxation of Alkali-metal and Halogen Nuclei: 7Li, 23Na, 85Rb, 87Rb, 133Cs, 19F, 35Cl, 37Cl, 79Br, 81Br, 127I -- Chapter 4 Bandshape Phenomena in Liquids -- 1 Introduction -- A Recent Developments -- B Coverage of the Report -- 2 Experimental Aspects -- A Fourier Transform versus Continuous Wave Spectra -- B Resolution Enhancement -- C Magnetic Field Inhomogeneities -- 3 Exchange of Magnetic Sites -- A General Aspects -- B Intramolecular Exchange -- C Intermolecular Exchange -- D Mechanistic Studies in Inorganic Chemistry -- 4 Relaxation Effects: Linewidths -- A Theoretical Work -- B Chemical Exchange Rates Determined by the Swift-Connick Approach -- C Linewidth Determinations in Paramagnetic Systems -- D Effects of Scalar Coupling to Quadrupolar Nuclei -- Chapter5 Multiple Resonance -- 1 Introduction -- 2 Theory of Multiple Resonance -- 3 Experimental Techniques -- 4 The Nuclear Overhauser Effect -- A Intramolecular -- B Intermolecular -- 5 Chemical Applications of Multiple Resonance -- A Decoupling: Simplification and Assignment -- B Selective Irradiation Experiments: Measurements of Magnitudes and Relative Signs of Coupling Constants -- C Chemical Shift Determination -- 6 Solid-state Studies -- Chapter6 Macromolecules -- 1 Introduction -- 2 Reviews -- 3 Synthetic Macromolecules -- A 1H High-resolution N.M.R. -- B Broadline N.M.R. -- C Spin-echo N.M.R. -- D 13C N.M.R. -- E 19F N.M.R. -- 4 Biological and Related Macromolecules -- A 1H N.M.R. of Synthetic Polypeptides -- B 1H N.M.R. of Natural and Related Polypeptides and Polysaccharides -- C 1H N.M.R. of Proteins -- D 1H N.M.R. of Enzymes -- E 1H N.M.R. of Polynucleotides -- F 13C Studies -- G Other Nuclei -- 5 Small Molecules -- A 1H Studies of Hydration -- B 1H N.M.R.- General Studies -- C 13C N.M.R. Studies -- D Other Nuclei. , E Counter-ion N.M.R. -- Chapter 7 Liquid Crystals and Micellar Solutions -- 1 Introduction -- 2 Reviews -- 3 Lyotropic Liquid Crystal Phases -- A Alkyl-chain Resonances -- B Water Studies -- C Counter-ion Studies -- D Vesicle Studies -- 4 Thermotropic Liquid Crystals -- 5 Micelles -- 6 Reversed Micelles -- 7 Microemulsions and Emulsions -- Chapter 8 The Solid State -- 1 General Introduction -- 2 Half-integral Spins in Diamagnetic Solids -- A Introduction -- B Theory of the Resonance Spectrum -- C Nuclear Spin-Lattice Relaxation Theory -- D Structural Studies -- E Motional Studies (Classical Regime) -- F Quantum Effects -- G High Resolution in Solids -- H N.M.R. Image Formation -- A Introduction -- B 2H N.M.R. -- C First-row Elements -- D Second-row Elements -- E Other Nuclei -- 4 Systems with Unpaired Electrons in the Absence of Magnetic Ordering -- A Non-metallic Paramagnetic Systems -- B Metals -- C Alloys -- D Semiconductors -- E Metal Hydrides -- F One-dimensional Metals -- 5 Ordered Magnetic Materials -- A Ferromagnetic Materials -- B Antiferromagnetic Materials -- C Ferrimagnetic Materials -- 6 New Apparatus and Techniques -- A Techniques -- B Analysis -- C Sources of Error -- D Apparatus -- 7 Surface Phenomena -- A Introduction -- B Adsorption on Graphite and Charcoal -- C Adsorption on Silica -- D Adsorption on Aluminas and other Surfaces -- E Zeolites -- Chapter 9 Medium Effects -- 1 Introduction -- 2 Non-specific Medium Effects -- 3 Effects due to Specific Interactions with the Medium -- A The ASIS Effect -- B Hydrogen-bonded Systems -- C Aqueous Systems -- D Ionic Solutions -- E Micellar Aggregation -- 4 Shift Reagents -- Author Index.

Note: Front Cover -- The Interpretation of Ultrastructure -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS -- PREFACE -- CHAPTER 1. CHEMICAL FIXATIVES FOR ELECTRON MICROSCOPY -- CONCLUSIONS -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION -- CHAPTER 2. WATER-SOLUBLE EMBEDDING MEDIA FOR ULTRASTRUCTURAL CYTOCHEMISTRY -- INTRODUCTION -- MATERIALS AND METHODS -- OBSERVATIONS -- DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION -- CHAPTER 3. CRITICAL EVALUATION OF ULTRASTRUCTURAL PATTERNS WITH RESPECT TO FIXATION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 4. INTERPRETATION OF ULTRASTRUCTURE IN THE CELL NUCLEUS -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION -- CHAPTER 5. CORRELATION OF ELECTRON MICROSCOPE AND X-RAY DIFFRACTION DATA IN ULTRASTRUCTURE STUDIES OF LIPOPROTEIN MEMBRANE SYSTEMS -- SUMMARY -- REFERENCES -- CHAPTER 6. QUANTITATIVE ELECTRON MICROSCOPY -- INTRODUCTION -- DISCUSSION -- SUMMARY -- REFERENCES -- CHAPTER 7. CYTOLOGY AND MICROCYTOLOGY OF LIVING AND FIXED CYTOPLASMIC CONSTITUENTS IN THE EGGS OF TUBIFEX AND THE CELL OF AMOBEA PROTEUS -- INTRODUCTION -- SUMMARY -- REFERENCES -- CHAPTER 8. LIGHT AND ELECTRON MICROSCOPIC STUDY OF MEMBRANOUS CYTOPLASMIC ORGANELLES -- INTRODUCTION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 9. NUCLEOSIDEPHOSPHATASE ACTIVITIES OF CYTOMEMBRANES -- CYTOCHEMICAL METHODS FOR ENZYME ACTIVITIES: MICROSCOPIC BIOCHEMISTRY -- PLASMA MEMBRANE -- ENDOPLASMIC RETICULUM -- THE GOLGI APPARATUS -- GOLGI APPARATUS AND LYSOSOMES -- SECRETORY GRANULES AND LYSOSOMES -- POSSIBLE ROLES OF NUCLEOSIDEPHOSPHATASES IN CYTOMEMBRANES -- POSSIBLE FUNCTIONAL SIGNIFICANCE OF THE INTIMATE TOPOGRAPHICAL RELATION BETWEEN LYSOSOMES AND GOLGI LAMELLAE -- DYNAMIC STEADY STATE: MEMBRANE FLOW IN ENDOPLASMIC RETICULUM, GOLGI APPARATUS AND LYSOSOMES. , CONCLUDING REMARKS -- SUMMARY -- REFERENCES -- CHAPTER 10. COMBINATION OF CYTOCHEMICAL STAINING METHODS FOR ENZYME LOCALIZATION WITH ELECTRON MICROSCOPY -- SUMMARY -- REFERENCES -- CHAPTER 11. NUCLEOPROTEIN LOCALIZATION IN ELECTRON MICROGRAPHS: METAL BINDING AND RADIOAUTOGRAPHY -- INTRODUCTION -- MATERIALS AND METHODS -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES -- CHAPTER 12. THE STUDY OF NATURAL AND ARTIFICIAL DNA-PLASMS BY THIN SECTIONS -- INTRODUCTION -- CONCLUSIONS AND DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES FOR THE DISCUSSION -- CHAPTER 13. NEGATIVE STAINING AND ITS USE IN THE STUDY OF VIRUSES AND THEIR SEROLOGICAL REACTIONS -- RESOLUTION AND CONTRAST -- INCREASING INSTRUMENTAL RESOLUTION BY SHADOWCASTING -- INCREASING RESOLUTION OF SPECIMEN PREPARATION -- NEGATIVE STAINING IN THEORY AND PRACTICE -- RESULTS AND DISCUSSION -- SUMMARY -- REFERENCES -- CHAPTER 14. AN ASSESSMENT OF NEGATIVE STAINING TECHNIQUES FOR REVEALING ULTRASTRUCTURE -- INTRODUCTION -- THE THEORY OF NEGATIVE STAINING -- THE PROPERTIES OF A GOOD NEGATIVE STAIN -- EXPERIMENTAL INVESTIGATION OF VARIOUS NEGATIVE STAINS -- THE BEST MATERIAL FOR A NEGATIVE STAIN -- CONTRAST LIMIT OF NEGATIVE STAINING -- STRUCTURES NOT SHOWN BY NEGATIVE STAINING -- STRUCTURAL SUBUNITS SHOWN BY NEGATIVE STAINING -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 15. THE FINER STRUCTURE OF THE MITOTIC APPARATUS -- INTRODUCTION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 16. INTERPRETATION OF THE ULTRATEXTURE IN GROWING PLANT CELL WALLS -- INTRODUCTION -- ULTRATEXTURES OF PRIMARY CELL WALLS -- THEORIES OF PASSIVE ORIENTATION -- ACTIVE ORIENTATION -- SUMMARY -- REFERENCES -- CHAPTER 17. THE ELECTRON MICROSCOPY AND ELECTRON DIFFRACTION ANALYSIS OF NATURAL CELLULOSE -- INTRODUCTION -- SUMMARY -- REFERENCES -- DISCUSSION -- REFERENCES TO DISCUSSION. , CHAPTER 18. THE MOLECULAR STRUCTURE OF LIPID-WATER SYSTEMS AND CELL MEMBRANE MODELS STUDIED WITH THE ELECTRON MICROSCOPE -- INTRODUCTION -- RESULTS AND DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 19. THE EVOLUTION OF INTRACELLULAR PHOSPHOLIPID MEMBRANE SYSTEMS -- SUMMARY -- REFERENCES -- CHAPTER 20. RECOVERY OF VIRUS FROM THE BLOOD OF RATS WITH INDUCED LEUKAEMIA -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 21. ELECTRON MICROSCOPY IN THE STUDY OF EMBRYONIC DIFFERENTIATION -- INTRODUCTION -- CYTOPLASMIC ARCHITECTURE AND DEVELOPMENTAL CAPACITIES IN EGGS AND EMBRYONIC CELLS -- ULTRASTRUCTURAL CHARACTERISTICS AS RELATED TO DETERMINATIVE EVENTS IN DEVELOPMENT -- CONCLUDING REMARKS -- SUMMARY -- REFERENCES -- DISCUSSION -- CHAPTER 22. NEW APPROACHES IN THE STUDY OF BIOLOGICAL ULTRASTRUCTURE BY HIGH-RESOLUTI ON ELECTRON MICROSCOPY -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- AUTHOR INDEX.

Note: Front Cover -- Biological Organization at the Cellular and Supercellular Level -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS AND PARTICIPANTS -- PREFACE -- CHAPTER 1. ELEMENTS OF REGULATORY CIRCUITS IN BACTERIA -- SUMMARY -- INTRODUCTION -- REGULATION OP ENZYMATIC ACTIVITY: ALLOSTERIC EFFECTS -- REGULATION OF PROTEIN SYNTHESIS -- REGULATION OF DNA REPLICATION: THE "REPLICON" HYPOTHESIS -- CONCLUDING REMARKS -- REFERENCES -- CHAPTER 2. THE KINETIC STRUCTURE OF ORGANISMS -- SUMMARY -- INTRODUCTION -- THE BOUNDARIES OF AN ORGANISM -- THECELLAS AN OPEN SYSTEM -- CATALYTIC CONTROL OF THE STEADY STATE -- EQUIFINALITY AND THE RECORD OF PAST EVENTS -- FLUX CONTROL AND GENETIC REDUNDANCY -- SEQUENCE INTERACTIONS -- HISTORICAL AND GENIC DETERMINATION -- CONCLUSIONS -- REFERENCES -- CHAPTER 3. STIMULATION OF THE RATE OF SYNTHESIS OF SPECIFIC MESSENGER RNA AFTER ENZYME INDUCTION IN E. COLI -- SUMMARY -- INTRODUCTION -- BASE SEQUENCE COMPLEMENTARITY WITH HOMOLOGOUS DNA REGIONS AS A BASIS FOR THE DETECTION OF SPECIFIC MESSENGER RNA -- DETECTION OF THE mRNA SPECIFICALLY RELATED TO THE "GAL" REGION -- DETECTION OF THE mRNA SPECIFICALLY RELATED TO THE "LAC" REGION -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 4. THE RELATIONSHIP OF THE HEREDITARY VIRUS OF DROSOPHILA TO ITS HOST -- SUMMARY -- REFERENCES -- CHAPTER 5. RELATIONSHIP BETWEEN CYTOPLASM AND CHROMOSOME IN THE TRANSMISSION OF MELANOTIC TUMOURS IN DROSOPHILA -- SUMMARY -- THE PHBNOTYPE AND ITS GENESIS -- TRANSMISSION OF CHARACTER -- DISCUSSION -- REFERENCES -- DISCUSSION -- CHAPTER 6. ASPECTS OF MUTUAL EXCLUSION IN TETRAHYMENA -- SUMMARY -- INTRODUCTION -- THE ORGANISM -- INTRA-LOCUS EXCLUSION -- INTER-LOCUS EXCLUSION -- INTER-ALLELIC EXCLUSION -- DISCUSSION -- REFERENCES. , CHAPTER 7. LOSS OF NUCLEAR POTENTIALITY IN THE SOMA VERSUS PRESERVATION OF NUCLEAR POTENTIALITY IN THE GERM LINE -- SUMMARY -- INTRODUCTION -- EXPERIMENT SWITH THE GALLMIDGE MAYETIOLA DESTRUCTOR (CECIDOMYIDAE) -- EXPERIMENTS WITH THE GERM LINE IN THE ANURA (AMPHIBIA ) -- EXPERIMENTS INVOLVING THE TRANSPLANTATION OF SOMATIC NUCLEI IN AMPHIBIA -- CONCLUSIONS -- REFERENCES -- CHAPTER 8. THE FOURTH MOMENT OF A CHARACTER DISTRIBUTION AS AN INDEX OF THE REGULATIVE EFFICIENCY OF THE GENETIC CODE -- SUMMARY -- I. DIFFERENCES IN KURTOSIS BETWEEN HATCHING TIME DISTRIBUTIONS IND, -- II. WHY SHOULD THE INTEGRATION OF THE GENETIC SYSTEM BE REFLECTED IN KURTOSIS? -- III. LEPTOKURTOSIS AND CHROMOSOMAL POLYMORPHISM IND -- IV. KURTOSIS AS AN INDICATION OF FITNESS -- ACKNO\VLEDGMENTS -- REFERENCES -- CHAPTER 9. ORIENTED CELL MOVEMENTS IN EMBRYOGENESIS -- SUMMARY -- INTRODUCTION -- CONTROL OF CELL MOVEMENTS -- DIRECTIONAL CONTROL -- MIGRATION OF PRECARDIAC MESODERM AS AN EXAMPLE OF CONTACT GUIDANCE -- REFERENCES -- CHAPTER 10. THE ROLE OF THE NUCLEIC ACIDS IN THE PROCESSES OF INDUCTION, REGULATION AND DIFFERENTIATION IN THE AMPHIBIAN EMBRYO AND THE UNICELLULAR ALGA, ACETABULARIA MEDITERRÁNEA -- SUMMARY -- INTRODUCTION -- EXPERIMENTAL EVIDENCE -- DISCUSSION -- ACKNOWLEDGMENT -- REFERENCES -- CHAPTER 11. THE ROLE OF REGIONAL SPECIFIC INDUCERS IN THE PRIMARY DETERMINATION AND DIFFERENTIATION OF AMPHIBIA -- SUMMARY -- INTRODUCTION -- FORMATION OF DEUTERENCEPHALIC INDUCTIONS BY CO-OPERATION OF TWO INDUCING FACTORS -- INACTIVATION OF INDUCING FACTORS B Y PROTEOLYTIC ENZYMES AND DIFFERENTIAL SENSITIVITY TO CHEMICAL AGENTS -- SPECIFIC ACTION VERSUS RELAIS-MECHANISM -- MECHANISM OF ACTION AT PRIMARY INDUCTION AND DIFFERENTIATION -- ACKNO\VLEDGMENT -- REFERENCES -- DISCUSSION -- CHAPTER 12. THE TRANSMISSION OF INFORMATION DURING PRIMARY EMBRYONIC INDUCTION -- SUMMARY. , INTRODUCTION -- THE TRANSMISSION OF INFORMATION -- THE TRANSMISSION OF MATERIALS -- THE RELEASE OF MATERIALS -- FINAL REMARKS -- REFERENCES -- DISCUSSION -- CHAPTER 13. SOME PROBLEMS OF DIFFERENTIATION AND INTEGRATION IN NEOPLASIA -- SUMMARY -- INTRODUCTION -- THE COURSE OF NEOPLASIA -- DIFFERENTIATION -- NEOPLASTIC DEVELOPMENT -- CONCLUSIONS -- REFERENCES -- CHAPTER 14. BIOLOGICAL ORGANIZATION: SUMMARIZING LECTURE -- CONCLUDING REMARKS -- REFERENCES -- Author Index.

Note: Front Cover -- Cell Growth and Cell Division -- Copyright Page -- Table of Contents -- LIST OF CONTRIBUTORS -- PREFACE -- CHAPTER 1. INDEPENDENT CYCLES OF CELL DIVISION AND OF DNA SYNTHESIS IN TETRAHYMENA -- INTRODUCTION -- THE PROBLEM -- RNA SYNTHESIS AND SYNCHRONOUS DIVISION -- ASYNCHRONOUS DNA SYNTHESIS AND SYNCHRONOUS DIVISION -- DISCUSSION -- SUMMARY -- REFERENCES -- CHAPTER 2. CELL DIVISION AND GROWTH STUDIES ON SYNCHRONIZED FLAGELLATES -- INTRODUCTION -- CONTINUOUS SYNCHRONIZED CULTURES -- OXYGEN CONSUMPTION DURING DIVISION -- STRUCTURES IN ASTASIA -- CELL DIVISION -- CELL FISSION AND THE CELL SURFACE -- SUMMARY -- REFERENCES -- CHAPTER 3. MACRONUCLEAR VARIABILITY OF BLEPHARISMA ASSOCIATED WITH GROWTH -- INTRODUCTION -- SPECIES AND STRAINS USED IN THIS STUDY -- NUTRITIONAL STUDIES -- TEMPERATURE STUDIES -- PRESSURE STUDIES -- STUDIES OF BLEPHARISMA GROWTH -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 4. FACETS OF INTRACELLULAR REGULATION OF MEIOSIS AND MITOSIS -- INTRODUCTION -- EXPERIMENTAL STUDIES -- THE MEIOTIC CYCLE IN TRILLIUM ERECTUM -- DEVELOPMENTAL STAGE AND SUSCEPTIBILITY TO INHIBITION -- NATURE OF UPSETS IN THE MEIOTIC CYCLE -- UPSET OF MEIOSIS I -- UPSET OF MEIOSIS II -- CHROMOSOME STRUCTURE -- AUTONOMY AT THE MOLECULAR LEVEL -- SUMMARY -- REFERENCES -- CHAPTER 5. NUCLEOTIDE METABOLISM AND RIBOSOMAL ACTIVITY DURING SYNCHRONIZED CELL DIVISION -- INTRODUCTION -- RESULTS AND DISCUSSION -- CONCLUSIONS -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCES -- CHAPTER 6. THE INTEGRATION OF PROTEIN AND RIBONUCLEIC ACID SYNTHESIS IN BACTERIA -- INTRODUCTION -- BACKGROUND -- RIBOSOMAL AND TRANSFER RNA -- THE CONTROL OF RNA SYNTHESIS -- OUTLOOK -- SUMMARY -- REFERENCES -- CHAPTER 7. RNA AND PROTEIN REPLACEMENT IN THE NUCLEUS DURING GROWTH AND DIVISION AND THE CONSERVATION OF COMPONENTS IN THE CHROMOSOME -- INTRODUCTION. , MATERIALS AND METHODS -- RESULTS -- DISCUSSION AND CONCLUSIONS -- SUMMARY -- REFERENCES -- CHAPTER 8. RNA AND PROTEIN IN NUCLEOCYTOPLASMIC INTERACTIONS -- RNA IN NUCLEOCYTOPLASMIC COMMUNICATION -- PROTEIN IN NUCLEOCYTOPLASMIC INTERACTIONS -- SUMMARY -- REFERENCES -- CHAPTER 9. THE CELL CYCLE OF A FISSION YEAST -- SUMMARY -- REFERENCES -- CONTROL MECHANISMS FOR CHROMOSOME REPRODUCTION IN THE CELL CYCLE -- INTRODUCTION -- LEVELS OF OPERATION OF CONTROL MECHANISMS -- PATTERNS OF CONTROL IN REPLICATION OF CHROMOSOMAL DNA -- SUMMARY -- REFERENCES -- CHAPTER 10. LES FACTEURS DE LA CROISSANCE DE TUMEURS ASSOCIÉES Á DES ORGANES EMBRYONNAIRES DE POULET -- CULTURES DE TUMEURS ANIMALES ET DE SOUCHES CELLULAIRES D'ORIGINES DIVERSES -- CULTURES DE TUMEURS HUMAINES FRAÎCHES -- CONCLUSIONS -- RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- CHAPTER 11. DYNAMISME DE L'ANA-TELOPHASE ET CYTODIERESE -- INTRODUCTION -- DIVISION NORMALE DE L'OEUF D'ARTEMIA -- DIVISION DES OEUFS ACTIVES -- INFLUENCE DES RÉACTIFS DES PROTÉINES SULFHYDRILEES SUR LA DIVISION -- CONCLUSION -- RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- CHAPTER 12. SOME OBSERVATIONS CONCERNING CELL MOVEMENT AND CELL CLEAVAGE -- SUMMARY -- REFERENCES -- CHAPTER 13. A NEW THEORY ON THE MECHANISM OF CELL DIVISION -- INTRODUCTION -- METHODS USED -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 14. FORCE OF CLEAVAGE OF THE DIVIDING SEA URCHIN EGG -- INTRODUCTION -- PART I -- PART II -- PART III -- CONCLUSION -- SUMMARY -- REFERENCES -- CHAPTER 15. SOME PROBLEMS OF CLEAVAGE IN RELATION TO THE CELL MEMBRANE -- INTRODUCTION -- THE RELATION BETWEEN THE MITOTIC APPARATUS AND CLEAVAGE -- THE CHANGES IN THE CELL MEMBRANE DURING CLEAVAGE -- THE BIOCHEMICAL BASIS OF CLEAVAGE -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES. , CHAPTER 16. APPLICATION DE TECHNIQUES CYTOLOGIQUES MODERNES À L'ÉTUDE DU PROBLÉME DES AMITOSES DANS LES BOURGEONS MUSCULAIRES -- MATÉRIEL ET TECHNIQUES -- OBSERVATIONS PERSONNELLES -- CONCLUSIONS GÉNÉRALES ET RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- CHAPTER 17. LE PROBLÈME DE L'AMITOSE -- SUMMARY -- BIBLIOGRAPHIE -- CHAPTER 18. CYTOPLASMIC DEOXYRIBONUCLEIC ACIDS: THEIR MITOCHONDRIAL LOCALIZATION AND SYNTHESIS IN SOMATIC CELLS UNDER EXPERIMENTAL CONDITIONS AND DURING THE NORMAL CELL CYCLE IN RELATION TO THE PREPARATION FOR MITOSIS -- INTRODUCTION -- POSITIVE FEULGEN REACTION IN THE CYTOPLASM -- QUANTITATIVE ESTIMATIONS OF DNA -- THE CYTOPLASMIC DNA IS CONFINED TO MODIFIED MITOCHONDRIA -- HISTORADIOAUTOGRAPHIC OBSERVATIONS -- REVERSIBILITY OF THE EFFECTS OF THE ACID DNASE -- OTHER EXPERIMENTAL PROCEDURES THAT CAUSE CYTOPLASMIC DNA -- HYPOTHESES AND SUGGESTIONS CONCERNING THE DNA LOCALIZATION AND SYNTHESIS INSIDE THE CYTOPLASM -- SUMMARY -- REFERENCES -- AUTHOR INDEX.

Note: Front Cover -- Cytogenetics of Cells in Culture -- Copyright Page -- Table of Contents -- Dedication -- LIST OF CONTRIBUTORS -- PREFACE -- CHAPTER 1. CYTOGENETIC ALTERATIONS IN MIXED CULTURES OF MAMMALIAN SOMATIC CELLS IN VITRO -- INTRODUCTION -- CONCLUSIONS AND SUMMARY -- REFERENCES -- CHAPTER 2. HYBRIDIZATION OF SOMATIC CELLS IN VITRO -- INTRODUCTION -- HYBRIDS OBTAINED UP TO DATE -- SELECTION AND VIABILITY OF HYBRIDS -- CHROMOSOME SEGREGATION -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 3. SELECTION PRESSURE IN MAMMALIAN CELL POPULATIONS -- INTRODUCTION -- THE CONTRIBUTION OF ERROR -- NORMAL SOMATIC TISSUES -- IRRADIATED SOMATIC TISSUES -- DISCUSSION -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 4. PHASE CINEMATOGRAPHY STUDIES ON THE EFFECTS OF RADIATION AND OF SOME CHEMICALS ON CELLS AND CHROMOSOMES -- INTRODUCTION -- CYTOLOGICAL RESPONSES OF VARIOUS CELLULAR ORGANELLES TO CERTAIN CHEMICALS -- BEHAVIOR OF CHROMOSOMES IN GRASSHOPPER SPERMATOCYTES FOLLOWING ß-IRRADIATTON -- BEHAVIOR OF THE TELOPHASE CHROMOSOME GROUP IN SILKWORM SPERMATOCYTES FOLLOWING ULTRAVIOLET MICROBEAM IRRADIATION -- GENERAL SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 5. CELLULAR INTERPRETATION OF ASPECTS OF THE ACUTE MAMMALIAN RADIATION SYNDROME -- INTRODUCTION -- DIFFICULTIES IN INTERPRETATION OF THE RADIATION SYNDROME -- SURVIVAL CURVES FOR MAMMALIAN CELLS IN VITRO -- INTERPRETATION OF THE ACUTE WHOLE-BODY RADIATION SYNDROME ON THE BASIS OF CELL REPRODUCTIVE KILLING -- FURTHER EXPERIMENTAL EVIDENCE FOR THIS FORMULATION -- APPLICATION OF THESE CONSIDERATIONS TO OTHER ASPECTS OF THE WHOLE-BODY RADIATION SYNDROME -- IDENTIFICATION OF THE SITE WITHIN THE CELL RESPONSIBLE FOR THE LETHAL ACTION -- SUMMARY -- REFERENCES -- CHAPTER 6. RETENTION OF EUPLOIDY AND MUTAGENICITY OF HETEROCHROMATIN IN CULTURE -- INTRODUCTION -- SEX HETEROCHROMATIN. , RETENTION OF EUPLOIDY M VITRO -- EUPLOID SPONTANEOUS NEOPLASIA -- INDUCED MALIGNANCIES -- IN VIVO TRANSPLANTATION OF POLYOMA-TRANSFORMED EUPLOID CELL LINES -- SPONTANEOUS TUMOR -- SPECIFICITY OF BUDR FOR SECONDARY CONSTRICTIONS -- TELOMERIC ASSOCIATION -- LESION OF SECONDARY CONSTRICTIONS OF X-CHROMOSOMES OF POLYOMA-TRANSFORMED CELLS -- CHARACTERISTICS OF AN ADENOVIRUS -- SUMMARY -- ADDENDUM -- REFERENCES -- CHAPTER 7. THE NATURE, ORIGIN, AND GENETIC IMPLICATIONS OF STRUCTURAL ABNORMALITIES OF THE SEX CHROMOSOMES IN MAN -- INTRODUCTION -- STRUCTURAL ABNORMALITIES OF THE X-CHROMOSOME -- ABNORMALITIES OF THE Y-CHROMOSOME -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCES -- CHAPTER 8. CHROMOSOME STUDIES IN THE GENERAL POPULATION -- INTRODUCTION -- COMPOSITION OF THE STUDY POPULATION -- METHOD -- GENERAL POPULATION -- DISCUSSION -- SUMMARY -- REFERENCES -- CHAPTER 9. ALTÉRATIONS CHROMOSOMIQUES DANS DES CELLULES CULTIVÉES EN PRÉSENCE D'EXTRAITS TISSULAIRES HÉTÉROSPÉCIFIQUES -- INTRODUCTION -- MATÉRIEL ET TECHNIQUES -- DISCUSSION -- RÉSUMÉ -- SUMMARY -- BIBLIOGRAPHIE -- CHAPTER 10. CHROMOSOMAL STUDIES ON HUMAN LEUCOCYTES FOLLOWING TREATMENT WITH RADIOACTIVE IODINE IN VIVO AND IN VITRO -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 11. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS -- INTRODUCTION -- MATERIALS AND METHODS -- EXPERIMENTAL RESULTS -- DISCUSSION -- SUMMARY -- REFERENCES -- CHAPTER 12. REGULATION OF DNA REPLICATION AND VARIEGATION-TYPE POSITION EFFECTS -- PATTERNS OF ASYNCHRONOUS REPLICATION -- LATE REPLICATION, HETEROPYCNOSIS, AND GENETIC INACTIVATION -- TESTS OF THE INACTIVATION HYPOTHESIS -- INDUCTION OF THE REPRESSED STATE -- HYPOTHESIS FOR A GENERAL REPRESSOR SYSTEM -- SUMMARY AND PREDICTIONS -- ACKNOWLEDGMENT -- REFERENCES. , CHAPTER 13. IDENTIFICATION AND CHARACTERIZATION OF HUMAN CHROMOSOMES BY DNA REPLICATION SEQUENCE -- INTRODUCTION -- CHROMOSOMAL CHARACTERISTICS -- COMMENTS -- SUMMARY -- REFERENCES -- CHAPTER 14. MUTAGENIC RESPONSE OF HUMAN SOMATIC CELL LINES -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS AND DISCUSSION -- CONCLUSIONS AND SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 15. DNA SYNTHESIS AND CHROMOSOMAL MORPHOLOGY OF CHINESE HAMSTER CELLS CULTURED IN MEDIA CONTAINING W-DEACETYL-N-METHYLCOLCHICINE ( COLCEMID ) -- INTRODUCTION -- PROCEDURES -- EXPERIMENTAL DATA -- DISCUSSION -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 16. HETEROCHROMATIN IN THE HUMAN MALE -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- SUMMARY -- REFERENCES -- CHAPTER 17. CHROMOSOME BREAKAGE ASSOCIATED WITH VIRUSES AND DNA INHIBITORS -- INTRODUCTION -- ROUS SARCOMA -- MEASLES -- DEOXYADENOSINE AND CYTOSINE ARABINOSIDE -- ROUS VIRUS AND HUMAN LEUCOCYTE CULTURES -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 18. QUANTITATION AND AUTOMATION OF CHROMOSOMAL DATA WITH SPECIAL REFERENCE TO THE CHROMOSOMES OF THE HAMSHIRE PIG (SUS SCROFA) -- INTRODUCTION -- MATERIALS AND METHODS -- RESULTS -- DISCUSSION -- SUMMARY -- REFERENCES -- AUTHOR INDEX.