ISSN:
1573-4951
Keywords:
cyclin-dependent kinase
;
CDK1
;
inhibitor
;
olomoucine
;
structure-based design
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Cyclin-dependent kinase 1 (CDK1), an enzyme participating in the regulation of the cell cycle, constitutes a possible target in the search for new antitumor agents. Starting from the purine derivative olomoucine and following a structure-based approach, potent inhibitors of this enzyme were rapidly identified. The molecular modeling aspects of this work are described.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008115004986
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