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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Inc
    Wound repair and regeneration 9 (2001), S. 0 
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It is uncertain how accurately classic signs of acute infection identify infection in chronic wounds, or if the signs of infection specific to secondary wounds are better indicators of infection in these wounds. The purpose of this study was to examine the validity of the “classic” signs (i.e., pain, erythema, edema, heat, and purulence) and the signs specific to secondary wounds (i.e., serous exudate, delayed healing, discoloration of granulation tissue, friable granulation tissue, pocketing at the base of the wound, foul odor, and wound breakdown). Thirty-six chronic wounds were assessed for these signs and symptoms of infection with interobserver reliability ranging from 0.53 to 1.00. The wounds were then quantitatively cultured, and 11 (31%) were found to be infected. Increasing pain, friable granulation tissue, foul odor, and wound breakdown showed validity based on sensitivity, specificity, discriminatory power, and positive predictive values. The signs specific to secondary wounds were better indicators of chronic wound infection than the classic signs with a mean sensitivity of 0.62 and 0.38, respectively. None of the signs or symptoms was a necessary indicator of infection, but increasing pain and wound breakdown were both sufficient indicators with specificity of 100%.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 2921-2926 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 82 (2000), S. 333-339 
    ISSN: 1439-6327
    Keywords: Key words Inert gas narcosis ; Oxygen uptake ; Diving ; Temperature regulation ; Exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous findings of a narcosis-induced reduction in heat production during cold water immersion, as reflected in oxygen uptake (V˙O2), have been attributed to the attenuation of the shivering response. The possibility of reduced oxygen utilization (V˙O2) by the muscles could not, however, be excluded. Accordingly, the present study tested the hypothesis that mild narcosis, induced by inhalation of a normoxic gas mixture containing 30% nitrous oxide (N2O), would affect V˙O2. Nine male subjects participated in both maximal and submaximal exercise trials, inspiring either room air (AIR) or a normoxic mixture containing 30% N2O. In the submaximal trials, the subjects exercised at 50% of maximal exercise intensity (W˙ max ) as determined in the maximal AIR trial. Though the subjects attained the same W˙ max in the AIR and N2O trials, maximal V˙O2 was significantly higher (P 〈 0.05) during the N2O condition [58.9 (SEM 3.1) ml · kg−1 · min−l] compared to the AIR condition [55.0 (SEM 2.4) ml · kg−1 · min−l]. However, the V˙O2-relative exercise intensity relationship was similar during both maximal AIR and maximal N2O at submaximal exercise intensities. There were no significant differences in the responses of oesophageal temperature, sweating rate, heart rate and ventilation between AIR and N2O in the maximal and submaximal tests. It was concluded that the previously reported narcosis-induced reductions in V˙O2 observed during cold water immersion can be attributed solely to a reduction in the shivering response rather than to decreased oxygen utilization by the muscles.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-0603
    Keywords: in vitro ; fluorescent dyes ; cell culture ; cytotoxicity ; L929
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A semi-quantitative procedure is described for measuring cell viability after short-term exposure to a test substance using a monolayer culture. Test substances are placed in direct contact with cell monolayers for various time intervals. The substances are removed and the monolayers are incubated in the presence of fluorescein diacetate. Monolayers are viewed under a fluorescent microscope and the percentage of fluorescing (viable) cells is estimated. The method is suitable for examining cytotoxic effects at short times of exposure and for discriminating between test substances that give similar, low toxicity endpoints in standard 24-h assays.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Hydrobiologia 269-270 (1993), S. 197-205 
    ISSN: 1573-5117
    Keywords: Pseudonitzschia ; domoic acid ; amnesic shellfish poisoning ; razor clams ; Dungeness crabs ; N.E. Pacific Ocean
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Members of the planktonic diatom genus Pseudonitzschia H. Peragallo, P. pungens (Grun.) Hasle f. multiseries (Hasle) Hasle and P. australis Frenguelli, that may produce the marine biotoxin, domoic acid, have been recognized in western Washington waters. Their distribution is not well-known in this area, probably because they often have been misidentified. However, they appear to be relatively common and may be abundant, especially in late spring and summer. Domoic acid, a potent neurotoxin, was found at levels up to 154 µg g−1 wet weight in razor clams, Siliqua patula Dixon, and Dungeness crabs, Cancer magister Dana, on the Pacific coast of Washington in late October 1991. It was also found in trace amounts in blue mussels, Mytilus edulis L., and oysters, Crassostrea gigas Thun., in the inland waters of northern Puget Sound in summer 1992. The presence of these potentially toxic diatoms signals the need for regular phytoplankton monitoring and additional shellfish monitoring to ensure that seafood is safe for human consumption. Further, studies are needed on the physiological ecology of the diatoms to determine the causative factors leading to production of the toxin.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 54 (1994), S. 827-830 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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