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  • 1
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    US/PRC CTD intercalibration report 1986-1990 (2006)
    Woods Hole Oceanographic Institution
    Details
    Publication Date: 2022-05-26
    Description: A series of laboratory intercalibrations of a CTD system were undertaken between 1986 and 1990 as part of cooperative research program between the United States (US) and People's Republic of China (PRC). A comparison of US and PRC calibration facility standards is carried out using a NBIS/EG&G Marine Instruments Mark IIIb CTD system as a "quasi-transfer standard." When compared with the quoted accuracy of the calibration facilities, pressure was found to be more accurate and temperatue was about as accurate as stated. The conductivity standard differences between facilities are difficult to assess because of the CTD conductivity sensor drift.
    Description: Funding was provided by the National Oceanographic and Atmospheric Administration under Grant No. NA85-AA-d-AC117.
    Keywords: CTD ; Calibration ; Intercalibration
    Repository Name: Woods Hole Open Access Server
    Type: Technical Report
    Format: 1397985 bytes
    Format: application/pdf
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    PAPER (OA)
  • 2
    Electronic Resource
    Electronic Resource
    Pigmented eccrine poroma with enhanced endothelin-1 expression: implications for mechanism of hyperpigmentation (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06560.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    FK506 promotes melanocyte and melanoblast growth and creates a favourable milieu for cell migration via keratinocytes: possible mechanisms of how tacrolimus ointment induces repigmentation in patients with vitiligo (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Vitiligo is an acquired pigmentary disorder characterized by depigmentation of skin and hair. As the pathogenesis of this disease is still obscure, the treatment of vitiligo has generally been unsatisfactory and often disappointing. Topical tacrolimus (FK506) ointment has recently been added to the armamentarium against this pigmentary disorder. Despite its clinical efficacy, the underlying mechanisms of how topical tacrolimus induces repigmentation in vitiligo have rarely been investigated. As tacrolimus ointment is applied directly to the skin, its impact on keratinocytes (KCs) requires thorough investigation.Objectives  To investigate the effects of FK506 on melanocyte (MC) and melanoblast (MB) growth via KCs.Methods  Cultured MCs and MBs were treated with supernatant of KC cultures conditioned with various concentrations of FK506. The impact of supernatant on MCs and MBs was assessed in terms of its effect on MC/MB proliferation, melanin formation and cell migration. The activities of matrix metalloproteinase (MMP)-2 and MMP-9, known for their influence on cell migration, were evaluated. The concentrations of MC/MB growth factors in the KC supernatant were also determined.Results  Results demonstrated that proliferation of both MCs and MBs was significantly enhanced by FK506-treated KC supernatant. In addition, the concentration of stem cell factor in KC supernatant increased dose-dependently with FK506 treatment. The supernatant from FK506-treated KC culture showed a significant increase in MMP-9 activity.Conclusions  Our study provides in vitro evidence demonstrating that direct interaction between FK506 and KCs creates a favourable milieu for MC growth and migration. Furthermore, our findings provide a possible mechanism explaining how tacrolimus ointment induces repigmentation in patients with vitiligo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06739.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    038
Digit Tip Regeneration and Global Gene Expression Profiling in the MRL SuperHealer Mouse (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The MRL mouse is the only known strain of mouse that can regenerate cardiac lesions and completely heal ear punches without scarring. To determine if the MRL also has greater regeneration capabilities in amputated digit tips, right paw digit tips of neonatal mice were dissected, with the left front paws as uncut controls. Controls used for regeneration comparison were the DBA, B6, C3H, and 129 inbred mouse strains. Consecutive X-ray images were captured of the left and right paws at 0, 7, 14, 21, and 28 days postamputation. MRL mouse digit tips regenerated greater in comparison to all strains tested (p 〈 0.05). We next undertook whole genome microarray analysis to identify the genetic mechanisms that contribute to differences in digit tip regeneration. Over 400 genes out of 15,000 were significantly differentially expressed (p 〈 0.05) in MRL and DBA mice at day 4 in comparison to day 0 control tissue. Of these, 170 genes were upregulated and 280 were downregulated in both mouse strains. Pathway analysis reveals that genes in the BMP/TGF pathway are differentially expressed in both mouse strains (p 〈 0.05). Multiple differences between MRL and DBA strains were found in transcription factors that are implicated in gastrulation, including FMN2 and SHRM. Additional differentially expressed genes include NET1 in the WNT signaling pathway. Immunohistochemistry indicates that these proteins are highly expressed in the nuclei of chondrocytes in regenerating digits. We conclude that MRL mice show greater regenerative capacity to heal digit tips and that the increased regenerative capacity of MRL mice may be due to strain specific increased expression of genes involved in the WNT pathway and genes involved in embryonic pattern formation.Acknowledgments:  This work was supported by Assistance Award DAMD17–03–2–0021 and is administered by the US Army Medical Research Activity, 820 Chandler St., Ft. Detrick, MD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215al.x
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  • 5
    Electronic Resource
    Electronic Resource
    FK506 inhibits tumour necrosis factor-α secretion in human keratinocytes via regulation of nuclear factor-κB (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Tacrolimus (FK506) ointment has been used for treatment of inflammatory dermatoses with remarkable success. Our previous studies have indicated that direct modulation of tacrolimus on keratinocytes (KCs) may have an impact on its therapeutic effect. The use of monoclonal antibody specific for tumour necrosis factor (TNF)-α has shown efficacy in treating both psoriasis and Crohn disease. Topical tacrolimus has also been shown to be effective for treating cutaneous manifestations of both diseases.Objectives  To explore the effects of FK506 on human KCs in terms of TNF-α secretion and to investigate the regulatory pathway involved.Methods  Ultraviolet (UV) B-irradiated cultured KCs were treated with various concentrations of FK506. At indicated time points after UVB irradiation we determined: (i) the TNF-α concentrations present in the culture supernatants; (ii) the activation and translocation of nuclear factor (NF)-κB in the cell nucleus; and (iii) the protein expressions of IκB kinase (IKK) and IκB in the cell lysates. In addition, a mouse model was used to corroborate our in vitro findings in vivo. More specifically, topical tacrolimus was applied on to mouse skin unilaterally after UVB irradiation. The effects of FK506 on nuclear NF-κB expression of UVB-irradiated mouse skin were determined.Results  Our results showed that FK506 dose-dependently downregulated the secretion of TNF-α from UVB-irradiated KCs. The activation and translocation of NF-κB in UVB-irradiated KCs were also dose-dependently suppressed by FK506. The degradation of IκB induced by UVB was also inhibited by FK506, while no change in IKK expression was noted regardless of UVB and FK506 treatment. Murine skin biopsies showed that nuclear NF-κB expression induced by UVB was inhibited by topical tacrolimus treatment.Conclusions  Our results indicate that FK506 inhibits TNF-α secretion in human KCs via direct regulation of NF-κB. This modulatory effect of FK506 on KCs offers a possible mechanism for how topical tacrolimus regulates cutaneous inflammatory conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06779.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A histological study on the development of the digestive system of Pseudosciaena crocea larvae and juveniles (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 67 (2005), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The ontogenetic development of the gut and accessory organs in large yellow croaker Pseudosciaena crocea was investigated using light microscopy from hatching up to the juvenile stage (40 days post hatch, dph). At 3 dph (mean ± s.d., 4·1 ± 0·1 mm total length, LT), coinciding with the buccopharynx opening, larvae started to feed exogenously, and the gut consisted of a well-developed buccopharynx, a partially-differentiated oesophagus and an intestine divided in three regions (anterior intestine, intermediate intestine and rectum). Yolk reserves were not completely depleted at the onset of exogenous feeding, and a period of mixed nutrition was observed up to 6 dph (4·3 ± 0·1 mm LT), when yolk was definitively exhausted. Important morphological changes occurred at the end of the larval period, coinciding with metamorphosis. At 17 dph (6·8 ± 0·6 mm LT), pyloric caeca differentiated at the junction of the pyloric stomach and the anterior intestine. Gastric glands were first observed at 21 dph (9·2 ± 1·2 mm LT), coinciding with the morphological development of the stomach in three different regions (cardiac, fundic and pyloric) according to the histological characteristics of their mucosa. At this age, large longitudinal folds appeared in the median and posterior oesophageal mucosa. These morphological and histological features suggested the achievement of a digestive system characteristic of large yellow croaker juveniles and adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0022-1112.2005.00812.x
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  • 7
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    A critical state framework for modelling bonded geomaterials (2007)
    Taylor & Francis
    In:  Geomechanics and Geoengineering, 2 (1). pp. 61-74.
    Details
    Publication Date: 2018-05-04
    Description: A simple unified critical state constitutive model for bonded geomaterials is presented in this paper. The model, which is called CASM-n, is an enhancement of an existing unified critical state model for reconstituted geomaterials (CASM). Characteristic behaviours of a bonded geomaterial such as the pre-yield higher strength and stiffness and the cohesive–frictional shearing mode in the post-yield region are taken into account and included in the reference model. The salient feature of the proposed model is the incorporation of cohesive component into the stress–dilatancy relationship. Consideration of the contribution of cohesion to plastic flow allows the modelling of delayed dilatancy and softening–contraction behaviour, which are two interesting phenomena observed in bonded geomaterials.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1080/17486020601164275
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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