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  • 1
    Electronic Resource
    Electronic Resource
    047
Stretching Magnitude-Dependent Inflammatory Response of Human Tendon Fibroblasts (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies have shown that cyclic mechanical stretching exerts anti-inflammatory effects on rabbit chondrocytes. But whether mechanical stretching has similar effects on human tendon fibroblasts are not known. This study therefore aimed to test the hypothesis that cyclic mechanical stretching regulates IL-1β induced COX-2 gene expression in a stretching magnitude-dependent manner. In custom-made silicone dishes, human patellar tendon fibroblasts (HPTFs) were grown on microgrooved culture surfaces, with which the shape and organization of HPTFs in vivo were closely mimicked. To induce inflammatory responses in HPTFs, 10 pM of IL-1β was added to the culture medium. A 4% or 8% cyclic uniaxial stretching was then applied to silicone dishes for 4 hrs using a custom-design stretching apparatus. After the end of stretching, total RNA of stretched and nonstretched tendon fibroblasts was collected, and RT-PCR was performed for measuring COX-2 mRNA expression levels. We found that tendon fibroblasts subjected to 4% stretching decreased COX-2 mRNA expression level by 20%(p = 0.0002; n = 6) compared to that of nonstretched, IL-1β-treated cells. However, cells subjected to 8% stretching showed a 39% increase (p = 0.007, n = 6) in COX-2 mRNA expression. Thus, the results of this study suggest that small stretching (4%) has anti-inflammatory effects on HPTFs in a mildly inflammatory environment such as that induced by 10 pM of IL-1β. In contrast, large stretching (8%) may amplify inflammatory responses of tendon fibroblasts. Therefore, physical therapy with low levels of tendon stretching may be beneficial in reducing mild tendon inflammation.Supported by the Arthritis Investigator Award and NIHAR049921 (JHW)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130215au.x
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of AFLP markers linked to one recessive genic male sterility gene in oilseed rape, Brassica napus (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 124 (2005), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The commercial utilization of heterosis in seed yield by means of hybrid varieties is of great importance for increasing oilseed rape production in China. This requires a functional system for the production of hybrid seed. The Brassica napus oilseed rape line 9012AB is a recessive epistatic genic male sterility (GMS) two-type line, in which the sterility is controlled by two pairs of recessive duplicate sterile genes (ms1 and ms2) interacting with one pair of a recessive epistatic inhibitor gene (rf). Homozygosity at the rf locus (rfrf) inhibits the expression of the recessive male sterility trait in homozygous ms1ms1ms2ms2 plants. This study was conducted to identify molecular markers for one of the male fertility/sterility loci in the B. napus male sterility line 9012AB. Sterile bulk (BS) and fertile bulk (BF) DNA samples prepared from male sterile and male fertile plants of the homozygous two-type line 9012AB were subjected to amplified fragment length polymorphic (AFLP) analysis. A total of 256 primer combinations were used and seven markers tightly linked to one recessive genic male sterile gene (ms) were identified. Among them, six fragments co-segregated with the target gene in the tested population, and the other one had a genetic distance of 4.3 cM. The markers identified in this study will greatly enhance the utilization of recessive GMS for the production of hybrid seed in B. napus oilseed rape in China.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.2005.01115.x
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic analysis of rapeseed self-incompatibility lines reveals significant heterosis of different patterns for yield and oil content traits (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 124 (2005), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Self-incompatibility is one of the most effective approaches to utilizing heterosis in oilseed rape around the world. To evaluate the heterosis of double low self-incompatibility, the possibility of combining seed yield and oil content, and the genetic effects of parents on their hybrid progenies, a 2-year field trial using a 3 × 22 NC II mating design was conducted during the 1999-2001 growing seasons in Wuhan, China. Significant differences in seed yield per plant and seed oil content were observed among the F1 hybrids and between F1 progenies and their parents. However, the heterosis for seed yield per plant was much greater than that for seed oil content. Mid-parent heterosis and high-parent heterosis of seed yield per plant ranged from 5.50 to 64.11% and from –2.81 to 46.02%, while those of seed oil content ranged from –1.55 to 7.44% and –3.61 to 6.55%, respectively. Non-additive genetic effects were a major mechanism that accounted for the yield heterosis in addition to additive effects. In contrast, seed oil content heterosis was mainly dependent on an additive genetic effect. General combining ability (GCA) determined the stability of hybrid cultivars. In hybrid breeding, parental materials might be selected by the sum of GCAs and variances of special combining abilities (SCAs) of female and male parents for traits affected by both additive and non-additive effects, and by the sum of GCAs of two parents for traits controlled mainly by additive effects. Primary branches and their siliques were the most important yield traits.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.2004.01069.x
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  • 4
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    Unknown
    Scale interactions on diurnal toseasonal timescales and their relevanceto model systematic errors (2006)
    INGV
    Details
    Publication Date: 2019-11-04
    Description: Examples of current research into systematic errors in climate models are used to demonstrate the importance of scale interactions on diurnal,intraseasonal and seasonal timescales for the mean and variability of the tropical climate system. It has enabled some conclusions to be drawn about possible processes that may need to be represented, and some recommendations to be made regarding model improvements. It has been shown that the Maritime Continent heat source is a major driver of the global circulation but yet is poorly represented in GCMs. A new climatology of the diurnal cycle has been used to provide compelling evidence of important land-sea breeze and gravity wave effects, which may play a crucial role in the heat and moisture budget of this key region for the tropical and global circulation. The role of the diurnal cycle has also been emphasized for intraseasonal variability associated with the Madden Julian Oscillation (MJO). It is suggested that the diurnal cycle in Sea Surface Temperature (SST) during the suppressed phase of the MJO leads to a triggering of cumulus congestus clouds, which serve to moisten the free troposphere and hence precondition the atmosphere for the next active phase. It has been further shown that coupling between the ocean and atmosphere on intraseasonal timescales leads to a more realistic simulation of the MJO. These results stress the need for models to be able to simulate firstly, the observed tri-modal distribution of convection, and secondly, the coupling between the ocean and atmosphere on diurnal to intraseasonal timescales. It is argued, however, that the current representation of the ocean mixed layer in coupled models is not adequate to represent the complex structure of the observed mixed layer, in particular the formation of salinity barrier layers which can potentially provide much stronger local coupling between the atmosphere and ocean on diurnal to intraseasonal timescales.
    Description: Published
    Description: JCR Journal
    Description: open
    Keywords: diurnal cycle ; MJO ; convection ; ocean-atmosphere interaction ; 03. Hydrosphere::03.01. General::03.01.01. Analytical and numerical modeling ; 03. Hydrosphere::03.03. Physical::03.03.03. Interannual-to-decadal ocean variability ; 03. Hydrosphere::03.03. Physical::03.03.04. Upper ocean and mixed layer processes
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
    Format: 2898490 bytes
    Format: application/pdf
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