Note: Medicinal Applications of Coordination Chemistry -- Contents -- Abbreviations -- CHAPTER 1 Introduction -- 1.1 Metals in Medicine - A Historical Perspective -- 1.2 Metals and Human Biochemistry -- 1.3 Metallopharmaceuticals -- 1.3.1 General Requirements -- 1.3.2 Structure-Activity Relationships -- 1.3.3 Clinical Trials -- 1.4 The Special Properties of Metals -- 1.4.1 Comparison with Organic and Biological Compounds -- 1.4.2 Coordination Chemistry -- CHAPTER 2 The Chemistry of Metals in a Nutshell -- 2.1 The Structure of Materials -- 2.1.1 States of Matter -- 2.1.2 Chemical Elements -- 2.1.3 Chemical Compounds -- 2.2 The Structures and Properties of Atoms -- 2.2.1 Electron Configurations -- 2.2.2 The Spacial Distribution of Electrons in Atoms -- 2.2.3 The Electronic Properties of Atoms and Ions -- 2.2.4 The Radii of Atoms and Ions -- 2.3 The Formation of Compounds -- 2.3.1 Chemical Bonds -- 2.3.2 The Ionic Bond -- 2.3.3 The Covalent Bond -- 2.3.4 The Coordinate Bond -- 2.3.5 Polarity in Bonding -- 2.4 The Chemistry of Metals - An Overview -- 2.4.1 The Oxidation Numbers and Electron Configurations of Metal Ions -- 2.4.2 The Structures of Metal Compounds -- 2.5 Bonding in Metal Complexes -- 2.5.1 The Crystal Field Theory and Octahedral Complexes -- 2.5.2 The MO Theory and Octahedral Complexes -- 2.5.3 The Eighteen-Electron Rule -- 2.5.4 The Crystal Field Theory and Complexes of CN 4 -- 2.6 The Magnetism and Spectroscopy of Metal Complexes -- 2.6.1 The Electronic Spectra of Metal Complexes -- 2.6.2 Lanthanide Luminescence -- 2.6.3 The Magnetic Properties of Transitional Element Complexes -- 2.7 The Energetics of Metal Complex Formation -- 2.7.1 Equilibrium or Stability Constants -- 2.7.2 Hard and Soft Donors or Acceptors -- 2.7.3 The Chelate and Macrocyclic Effects -- 2.8 Reactions at Metal Centres -- 2.8.1 Thermodynamic and Kinetic Stability. , 2.8.2 Substitution Reactions at Metal Centres -- 2.8.3 Mechanisms of Substitution at Metal Centres -- 2.9 Redox Potentials -- 2.10 Conclusions -- CHAPTER 3 Diagnostic Medicine -- 3.1 Introduction -- 3.2 Anatomical Imaging -- 3.2.1 Magnetic Resonance Imaging Contrast Agents -- 3.2.2 X-ray Contrast Agents -- 3.3 Functional Imaging -- 3.3.1 Radiopharmaceuticals for Functional Imaging -- 3.3.2 Nuclear Medicine -- 3.3.3 Radiopharmaceuticals -- 3.3.4 Aspects of Technetium Chemistry -- 3.3.5 Blood-pool Imaging and Labelled Blood Cells -- 3.3.6 99mTc SPECT Imaging Agents for Bone -- 3.3.7 Kidney Imaging -- 3.3.8 Liver and Hepatobiliary System -- 3.3.9 Heart SPECT and PET Imaging -- 3.3.10 Brain Imaging -- 3.3.11 Tumors Abscesses and Hypoxia -- 3.3.12 Synthetic Approaches to Bifunctional 99mTc Radiopharmaceuticals -- 3.4 In vitro Applications -- CHAPTER 4 Therapeutic Medicine -- 4.1 The Use of Metal Compounds in Therapy -- 4.2 Chelation Therapy -- 4.2.1 Metal Sequestration -- 4.2.2 Macrocyclic Antibiotics -- 4.2.3 Metal Intoxication -- 4.2.4 Thalassaemia-Iron -- 4.2.5 Wilson Disease-Copper -- 4.3 Cancer Therapy -- 4.3.1 Metal Complexes in Cancer Therapy -- 4.3.2 Platinum and Palladium Anticancer Agents -- 4.3.3 Non-Platinum Anticancer Agents -- 4.4 Rheumatoid Arthritis -- 4.4.1 Introduction -- 4.4.2 Gold Chemistry -- 4.4.3 Gold Compounds for the Treatment of Rheumatoid Arthritis -- 4.5 Diabetes -- 4.5.1 Vanadium and Diabetes -- 4.5.2 Vanadium Chemistry -- 4.5.3 Vanadium Salts as Insulin Mimics -- 4.5.4 Vanadium Coordination Compounds as Insulin Mimics -- 4.5.5 Mechanism of Action of Vanadium Compounds -- 4.6 Cardiovascular System -- 4.6.1 In vivo Management of Gaseous Compounds -- 4.6.2 Superoxide Dismutase Mimics -- 4.6.3 Nitric Oxide Management -- 4.7 Therapeutic Radiopharmaceuticals -- 4.7.1 Radiation Therapy -- 4.7.2 α-Emitters -- 4.7.3 β-Emitters. , 4.7.4 Radiosensitisers -- CHAPTER 5 Metallopharmaceuticals Design -- 5.1 Introduction -- 5.2 Structure Activity Relationships -- 5.2.1 Organic Molecules -- 5.2.2 Metallopharmaceuticals -- 5.3 Future Directions -- Further Reading -- Subject Index.