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  • 1
    Online Resource
    Online Resource
    p73 G4C14‐to‐A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck
    Wiley ; 2009
    In:  International Journal of Cancer Vol. 125, No. 11 ( 2009-12), p. 2660-2665
    Details
    In: International Journal of Cancer, Wiley, Vol. 125, No. 11 ( 2009-12), p. 2660-2665
    Abstract: P73 plays an important role in modulating cell‐cycle control, inducing apoptosis, and inhibiting cell growth. A novel noncoding p73 G4C14‐to‐A4T14 exon 2 polymorphism was associated with risk of squamous cell carcinoma of the head and neck (SCCHN). We hypothesized that p73 G4C14‐to‐A4T14 polymorphism modulates risk of second primary malignancies (SPM) in patients after index SCCHN. We followed a cohort of 1,384 patients diagnosed with incident SCCHN between May 1995 and January 2007 for SPM development. Log‐rank test and Cox proportional hazard models were used to compare SPM‐free survival and SPM risk between the different genotype groups. Our results showed that patients carrying the p73 variant AT allele were less likely to develop SPM compared with the patients with p73 GC/GC genotype (Log‐rank test, p = 0.013). Compared with the p73 GC/GC genotype, there was a significantly reduced risk of SPM associated with the p73 GC/AT genotype (HR, 0.61, 95% CI, 0.40–0.93) and the combined p73 GC/AT+AT/AT genotypes (HR, 0.59, 95% CI, 0.39–0.89), but a nonsignificantly reduced risk for p73 AT/AT genotype (HR, 0.44, 95% CI, 0.14–1.41). The p73 AT allele was significantly associated with risk of SPM in an allele dose‐response manner ( p = 0.011 for trend). The risk of SPM associated with p73 variant genotypes (GC/AT+AT/AT) was more pronounced in several subgroups ( e.g ., older patients, men, minorities, ever smokers, and ever drinkers). Our results support that this p73 polymorphism may be a marker for risk of SPM among patients with an incident SCCHN. © 2009 UICC
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v125:11
    DOI: 10.1002/ijc.24570
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2009
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    detail.hit.zdb_id: 1474822-8
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  • 2
    Online Resource
    Online Resource
    Squamous cell carcinoma of the head and neck in never smoker–never drinkers: A descriptive epidemiologic study
    Wiley ; 2008
    In:  Head & Neck Vol. 30, No. 1 ( 2008-01), p. 75-84
    Details
    In: Head & Neck, Wiley, Vol. 30, No. 1 ( 2008-01), p. 75-84
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/hed.v30:1
    DOI: 10.1002/(ISSN)1097-0347
    DOI: 10.1002/hed.20664
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2001440-5
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  • 3
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    P045: Esthesioneuroblastoma: 25 years at a Single Institution
    Wiley ; 2007
    In:  Otolaryngology–Head and Neck Surgery Vol. 137, No. S2 ( 2007-08)
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 137, No. S2 ( 2007-08)
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1016/j.otohns.2007.06.556
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2008453-5
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  • 4
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    Online Resource
    Esthesioneuroblastoma: 25‐year experience at a single institution
    Wiley ; 2008
    In:  Otolaryngology–Head and Neck Surgery Vol. 138, No. 4 ( 2008-04), p. 452-458
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 138, No. 4 ( 2008-04), p. 452-458
    Abstract: To evaluate outcomes for patients with esthesioneuroblastoma treated at a single institution during a 25‐year period. Design Eighteen patients with pathologic diagnosis of esthesioneuroblastoma between 1980 and 2004 were retrospectively identified. Results Two patients had Kadish A, seven had Kadish B, and nine had Kadish C disease. The mean follow‐up was 71 months. Treatment regimens consisted of surgery alone (four patients), surgery followed by postoperative radiation (six patients), surgery followed by postoperative chemoradiotherapy (three patients), preoperative radiotherapy (two patients), preoperative chemoradiotherapy (one patient), chemoradiotherapy (one patient), and surgery plus chemotherapy (one patient). Surgical approaches (n = 17) consisted of 13 traditional craniofacial resections, one endoscopic‐assisted cranionasal resection, and three minimally invasive endoscopic resections. The 10‐year disease‐specific survival was 80%. The overall recurrence‐free survival at five and 10 years was 62% and 46%, respectively. Positive surgical margins and TNM staging predicted survival. Conclusion Both endoscopic and open surgical approaches have been successful in treating a small number of esthesioneuroblastoma patients with high survival and low rate of surgical complications.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1016/j.otohns.2007.12.038
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2008453-5
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  • 5
    Online Resource
    Online Resource
    The role of salvage surgery in patients with recurrent squamous cell carcinoma of the oropharynx
    Wiley ; 2009
    In:  Cancer Vol. 115, No. 24 ( 2009-12-15), p. 5723-5733
    Details
    In: Cancer, Wiley, Vol. 115, No. 24 ( 2009-12-15), p. 5723-5733
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Article
    DOI: 10.1002/cncr.v115:24
    DOI: 10.1002/cncr.24595
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 6
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    Online Resource
    Chronic Retropharyngeal Abscess Presenting as Obstructive Sleep Apnea
    Ovid Technologies (Wolters Kluwer Health) ; 2008
    In:  Pediatric Emergency Care Vol. 24, No. 6 ( 2008-06), p. 382-384
    Details
    In: Pediatric Emergency Care, Ovid Technologies (Wolters Kluwer Health), Vol. 24, No. 6 ( 2008-06), p. 382-384
    Type of Medium: Online Resource
    ISSN: 0749-5161
    URL: Article
    DOI: 10.1097/PEC.0b013e318177a6d9
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2008
    detail.hit.zdb_id: 2053985-X
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  • 7
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    Online Resource
    Supraglottoplasty for Laryngomalacia With Obstructive Sleep Apnea
    Wiley ; 2008
    In:  The Laryngoscope Vol. 118, No. 10 ( 2008-10), p. 1873-1877
    Details
    In: The Laryngoscope, Wiley, Vol. 118, No. 10 ( 2008-10), p. 1873-1877
    Abstract: Objectives/Hypothesis: To determine if supraglottoplasty (SGP) is effective in reversing abnormal respiratory parameters in children with laryngomalacia and obstructive sleep apnea (OSA). Study Design: Retrospective case series at a tertiary referral children's hospital. Methods: Ten patients with laryngomalacia and OSA as documented by polysomnography underwent SGP between 2005 and 2007. Data collected included age, findings on flexible and rigid endoscopy, type of procedure performed, and postoperative course. The postoperative polysomnographies were reviewed to identify changes in obstructive apnea index, obstructive apnea/hypopnea index, respiratory disturbance index, and low arterial oxygen saturation (O 2 nadir) after SGP. Results: All 10 patients were successfully extubated after SGP. There were no peri‐ or postoperative complications, and no patient required a subsequent airway procedure. Each patient had a postoperative nocturnal polysomnography performed after SGP at 11 weeks (range 2–29 weeks). Caregivers reported mild improvement (10%), significant improvement (70%), and complete resolution (20%) of stridor and nocturnal snoring at a follow‐up visit 4 weeks after discharge. Marked improvements were observed in obstructive apnea index, obstructive apnea/hypopnea index, respiratory disturbance index and O 2 nadir, all of which were statistically significant ( P 〈 .05). Conclusions: Polysomnography should be considered in the initial evaluation of infants with moderate laryngomalacia to rule out OSA. SGP is an effective treatment for infants with laryngomalacia and OSA. The significant benefits of the procedure outweigh thelow morbidity. Improvement after surgery was reliably confirmed by polysomnography in this study.
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Article
    DOI: 10.1097/MLG.0b013e31817e7441
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2026089-1
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  • 8
    Online Resource
    Online Resource
    S248 – Supraglottoplasty for Laryngomalacia with Sleep Apnea
    Wiley ; 2008
    In:  Otolaryngology–Head and Neck Surgery Vol. 139, No. S2 ( 2008-08)
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 139, No. S2 ( 2008-08)
    Abstract: To determine if supraglottoplasty is effective in reversing abnormal respiratory parameters in children with laryngomalacia and obstructive sleep apnea. Methods 10 patients with laryngomalacia and obstructive sleep apnea as documented by polysomnography underwent supraglottoplasty at a tertiary referral children's hospital between 2005 and 2007. Retrospective data collection included age, findings on flexible and rigid endoscopy, type of procedure performed, and postoperative course. The postoperative polysomnographies were reviewed to identify changes in obstructive apnea index (OAI), obstructive apnea/hypopnea index (OAHI), respiratory disturbance index (RDI), and low arterial oxygen saturation (O2 nadir) after supraglottoplasty. Pre‐ and postoperative mean data were calculated, and comparisons were made with a Student's T‐test. Results All 10 patients were successfully extubated following supraglottoplasty. There were no perioperative or postoperative complications, and no patient required a subsequent airway procedure. Each patient had a postoperative nocturnal polysomnography performed following supraglottoplasty at 11 weeks (range 2–29 weeks). Caregivers reported mild improvement (10%), significant improvement (70%), and complete resolution (20%) of stridor and nocturnal snoring at a follow‐up visit 4 weeks after hospital discharge. Marked improvements were observed in OAI, OAHI, RDI and O2 nadir, all of which were statistically significant (p 〈 0.05). Conclusions Polysomnography should be included in the initial evaluation of infants with laryngomalacia to rule out obstructive sleep apnea. Supraglottoplasty is an effective treatment for infants with laryngomalacia and obstructive sleep apnea. The significant benefits of the procedure outweigh the low morbidity. Improvement after surgery can be reliably confirmed by polysomnography.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1016/j.otohns.2008.05.423
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2008453-5
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  • 9
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    Online Resource
    Oropharyngeal Reconstruction for Advanced Cancer
    Wiley ; 2008
    In:  Otolaryngology–Head and Neck Surgery Vol. 139, No. S2 ( 2008-08)
    Details
    In: Otolaryngology–Head and Neck Surgery, Wiley, Vol. 139, No. S2 ( 2008-08)
    Abstract: To assess perioperative morbidity, functional outcomes, and survival following microvascular and regional flap reconstruction of the oropharynx after advanced oncologic resection. Methods 65 patients underwent oropharyngeal reconstruction for late stage primary (35.4%), second primary (10.8%), or recurrent (53.8%) oropharyngeal and oral cavity squamous cell carcinoma at a tertiary cancer center between 1997 and 2007. 50 (76.9%) males and 15 (23.1%) females with a median age of 59.2 years (range 28.6 to 76.1 years) were reconstructed with rectus myocutaneous free flaps (30.8%), anterolateral thigh free flaps (27.7%), radial forearm free flaps (20%), pectoralis myocutaneous pedicled flaps (15.4%), and fibula osseocutaneous free flaps (6.2%). Results The median follow‐up time following oropharyngeal reconstruction was 36.3 months (range 1.3 to 144.2 months). There were no complete flap failures and only 1 partial flap failure. 32 (49.2%) patients experienced postoperative complications including 11 wound infections/dehiscences, 7 fistulas, 7 donor site complications, and 11 postoperative pneumonias. Mean intensive care unit nights and total days hospitalized were 2.8 and 9.6, respectively. Of 56 patients undergoing a tracheostomy, 48 (73.8%) were decannulated a median of 13 days (range 5 to 426 days) following surgery. 42 (64.7%) remained at least partially feeding tube‐dependent, but 41 (63.1%) attained at least 80% oral speech intelligibility. 3‐and 5‐year overall survivals following reconstruction were 49.1% and 37.3%, respectively. Conclusions Selected patients who undergo reconstruction for extensive oropharyngeal defects following surgery for advanced cancer can attain long‐term survival. While most patients achieve decannulation and functional speech, almost 2/3rds remain feeding tube‐dependent.
    Type of Medium: Online Resource
    ISSN: 0194-5998 , 1097-6817
    URL: Article
    DOI: 10.1016/j.otohns.2008.05.105
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2008453-5
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  • 10
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    Online Resource
    Matched-Pair Analysis of Race or Ethnicity in Outcomes of Head and Neck Cancer Patients Receiving Similar Multidisciplinary Care
    American Association for Cancer Research (AACR) ; 2009
    In:  Cancer Prevention Research Vol. 2, No. 9 ( 2009-09-01), p. 782-791
    Details
    In: Cancer Prevention Research, American Association for Cancer Research (AACR), Vol. 2, No. 9 ( 2009-09-01), p. 782-791
    Abstract: It is unknown whether population-level racial or ethnic disparities in mortality from squamous cell carcinoma of the head and neck (SCCHN) also occur in the setting of standardized multidisciplinary-team directed care. Therefore, we conducted a matched-pair study that controlled for several potentially confounding prognostic variables to assess whether a difference in survival exists for African American or Hispanic American compared with non-Hispanic white American SCCHN patients receiving similar care. Matched pairs were 81 African American case and 81 non-Hispanic white control patients and 100 Hispanic American cases and 100 matched non-Hispanic white controls selected from 1,833 patients of a prospective epidemiologic study of incident SCCHN within a single, large multidisciplinary cancer center. Matching variables included age (±10 years), sex, smoking status (never versus ever), site, tumor stage (T1-2 versus T3-4), nodal status (negative versus positive), and treatment. Cases and controls were not significantly different in proportions of comorbidity score, alcohol use, subsite distribution, overall stage, or tumor grade. Matched-pair and log-rank analyses showed no significant differences between cases and controls in recurrence-free, disease-specific, or overall survival. Site-specific analyses suggested that more aggressive oropharyngeal cancers occurred more frequently in minority than in non-Hispanic white patients. We conclude that minority and non-Hispanic white SCCHN patients receiving similar multidisciplinary-team directed care at a tertiary cancer center have similar survival results overall. These results encourage reducing health disparities in SCCHN through public-health efforts to improve access to multidisciplinary oncologic care (and to preventive measures) and through individual clinician efforts to make the best multidisciplinary cancer treatment choices available for their minority patients. The subgroup finding suggests a biologically based racial/ethnic disparity among oropharyngeal patients and that prevention and treatment strategies should be tailored to different populations of these patients.
    Type of Medium: Online Resource
    ISSN: 1940-6207 , 1940-6215
    URL: Article
    DOI: 10.1158/1940-6207.CAPR-09-0154
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2009
    detail.hit.zdb_id: 2422346-3
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