In:
Clinical and Applied Thrombosis/Hemostasis, SAGE Publications, Vol. 15, No. 2 ( 2009-04), p. 233-238
Abstract:
Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser 413 /Cys 413 PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subjects were investigated. The Ser 413 /Ser 413 genotype frequency was 53% (lupus), 36% (rheumatoid arthritis), and 35% (healthy subjects). The Ser 413 allele was associated with systemic lupus erythematosus ( P = .04, odds ratio = 1.76, 95% confidence interval = 1.01-3.06). In all, 4 patient carriers of Ser 413 /Ser 413 genotype, developed thrombotic events. The lupus patients identified with Ser 413 /Ser 413 genotype showed an increased damage (57%), compared with Ser 413 /Cys 413 and Cys 413 /Cys 413 genotypes, with significant difference ( P = .03). These findings suggest an association of Ser 413 /Ser 413 genotype with greater damage index score and Ser 413 allele with systemic lupus erythematosus. Besides, PAI-2 polymorphism could be related with thrombotic phenomena in systemic lupus erythematosus
Type of Medium:
Online Resource
ISSN:
1076-0296
,
1938-2723
DOI:
10.1177/1076029607308868
Language:
English
Publisher:
SAGE Publications
Publication Date:
2009
detail.hit.zdb_id:
2230591-9
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