In:
Acta Paediatrica, Wiley, Vol. 95, No. 2 ( 2006-02), p. 170-175
Abstract:
Aim: To clarify the clinical significance of acanthosis nigricans (AN) and the association of gene polymorphisms in the β2‐ and β3‐adrenergic receptors (B2ADR and B3ADR) in Japanese obese children and adolescents. Methods: Seventy obese subjects (56 boys, 14 girls) from 5 to 19 y of age were examined as to clinical features. Genetic analyses were performed in 83 obese subjects (61 boys, 22 girls), 2 to 17 y of age. Typing of gene polymorphisms in B2ADR and B3ADR was achieved by polymerase chain reaction (PCR) of genomic DNA and restriction fragment‐length polymorphism analysis (PCR‐RFLP). Results: The group with AN ( n =30) had higher values for percent overweight, BMI, waist circumference, fasting insulin, HOMA‐R, leptin and PAI‐1 than the AN‐negative group ( n =40), but there were no significant differences in age, sex or percent body fat between the two groups. The prevalences of B2ADR Gly16 and B3ADR Arg64 were significantly higher in AN‐positive ( n =26) than in AN‐negative ( n =57) subjects. In addition, the AN frequency was significantly higher in the group with both Gly16 and Arg64 than in the group with neither of these alleles (55.6% vs 12.5%, p 〈 0.05). Conclusion: We demonstrate that AN is a useful clinical marker for the severity of obesity associated with a high BMI, and that B2ADR Gly16 and B3ADR Arg64 are associated synergistically with AN in obese children and adolescents.
Type of Medium:
Online Resource
ISSN:
0803-5253
,
1651-2227
DOI:
10.1111/apa.2006.95.issue-2
DOI:
10.1111/j.1651-2227.2006.tb02202.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
1492629-5
detail.hit.zdb_id:
1501466-6
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