In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 26, No. 9 ( 2006-09), p. 1122-1127
Abstract:
Neuroimaging studies in right-handed patients with left hemisphere brain lesions have demonstrated a shift of language activity from left to right inferior frontal gyrus (IFG). This shift may be caused by greater right hemisphere dominance before the injury or by reduced inhibitory activity of the injured left hemisphere. We simulated a brain lesion applying transcranial-magnetic stimulation over left IFG in normal subjects, while simultaneously measuring language activity with positron — emission tomography. Interference with transcranial-magnetic stimulation decreased activity in left and increased it in right IFG in all subjects. We thus demonstrate for the first time that a rightward shift of language activity is caused by the brain lesion and not by greater right-hemisphere dominance, thus supporting the hypothesis of reduced transcallosal inhibition.
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1038/sj.jcbfm.9600350
Language:
English
Publisher:
SAGE Publications
Publication Date:
2006
detail.hit.zdb_id:
2039456-1
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