In:
The Journal of Immunology, The American Association of Immunologists, Vol. 182, No. 1_Supplement ( 2009-04-01), p. 133.33-133.33
Abstract:
While the development of an efficacious vaccine against TB remains a global priority, the mechanisms of protection and reasons for variability of the BCG vaccine remain poorly understood. Several studies suggest that variation in host genes can affect susceptibility to TB infection. We hypothesized that variation in innate immunity genes is associated with altered immune responses to BCG and its clinical efficacy. Infants (N=12000) were vaccinated at birth with BCG and followed prospectively in a nested case-control study to identify those with active TB and exposed individuals who did not develop disease. Blood samples were collected and re-stimulated with BCG to assess innate and T cell responses. We are examining single nucleotide polymorphisms in TLR pathway genes to determine which variants are associated with BCG-induced cytokine responses. In preliminary analyses, individuals with TLR1 deficiency (TLR1_T1805G) had decreased IL-10 production, but no alteration in IFN-γ or IL-2. Studies are underway to determine whether polymorphisms in 10 additional TLR pathway genes are associated with these responses. To our knowledge, this is the first study to examine whether variation in innate immune genes is associated with different types of BCG-induced immunity. Supported by: Puget Sound Partners for Global Health, the Dana Foundation, and NIH Contract NO1-AI-70022.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.182.Supp.133.33
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2009
detail.hit.zdb_id:
1475085-5
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