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  • 1
    Online Resource
    Online Resource
    American Meteorological Society ; 2009
    In:  Journal of Climate Vol. 22, No. 6 ( 2009-03-15), p. 1424-1445
    In: Journal of Climate, American Meteorological Society, Vol. 22, No. 6 ( 2009-03-15), p. 1424-1445
    Abstract: Sudden changes of the Atlantic meridional overturning circulation (AMOC) are believed to have caused large, abrupt climate changes over many parts of the globe during the last glacial and deglacial period. This study investigates the mechanisms by which a large freshwater input to the subarctic North Atlantic and an attendant rapid weakening of the AMOC influence North Pacific climate by analyzing four different ocean–atmosphere coupled general circulation models (GCMs) under present-day or preindustrial boundary conditions. When the coupled GCMs are forced with a 1-Sv (Sv ≡ 106 m3 s−1) freshwater flux anomaly in the subarctic North Atlantic, the AMOC nearly shuts down and the North Atlantic cools significantly. The South Atlantic warms slightly, shifting the Atlantic intertropical convergence zone southward. In addition to this Atlantic ocean–atmosphere response, all of the models exhibit cooling of the North Pacific, especially along the oceanic frontal zone, consistent with paleoclimate reconstructions. The models also show deepening of the wintertime Aleutian low. Detailed analysis of one coupled GCM identifies both oceanic and atmospheric pathways from the Atlantic to the North Pacific. The oceanic teleconnection contributes a large part of the North Pacific cooling: the freshwater input to the North Atlantic raises sea level in the Arctic Ocean and reverses the Bering Strait throughflow, transporting colder, fresher water from the Arctic Ocean into the North Pacific. When the Bering Strait is closed, the cooling is greatly reduced, while the Aleutian low response is enhanced. Tropical SST anomalies in both the Atlantic and Pacific are found to be important for the equivalent barotropic response of the Aleutian low during boreal winter. The atmospheric bridge from the tropical North Atlantic is particularly important and quite sensitive to the mean state, which is poorly simulated in many coupled GCMs. The enhanced Aleutian low, in turn, cools the North Pacific by increasing surface heat fluxes and southward Ekman transport. The closure of the Bering Strait during the last glacial period suggests that the atmospheric bridge from the tropics and air–sea interaction in the North Pacific played a crucial role in the AMOC–North Pacific teleconnection.
    Type of Medium: Online Resource
    ISSN: 1520-0442 , 0894-8755
    RVK:
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2009
    detail.hit.zdb_id: 246750-1
    detail.hit.zdb_id: 2021723-7
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  • 2
    Online Resource
    Online Resource
    Proceedings of the National Academy of Sciences ; 2008
    In:  Proceedings of the National Academy of Sciences Vol. 105, No. 31 ( 2008-08-05), p. 10895-10900
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 105, No. 31 ( 2008-08-05), p. 10895-10900
    Abstract: Chronic cholestasis often results in premature death from liver failure with fibrosis; however, the molecular mechanisms contributing to biliary cirrhosis are not demonstrated. In this article, we show that the death signal mediated by TNF-related apoptosis-inducing ligand (TRAIL) receptor 2/death receptor 5 (DR5) may be a key regulator of cholestatic liver injury. Agonistic anti-DR5 monoclonal antibody treatment triggered cholangiocyte apoptosis, and subsequently induced cholangitis and cholestatic liver injury in a mouse strain-specific manner. TRAIL- or DR5-deficient mice were relatively resistant to common bile duct ligation-induced cholestasis, and common bile duct ligation augmented DR5 expression on cholangiocytes, sensitizing mice to DR5-mediated cholangitis. Notably, anti-DR5 monoclonal antibody-induced cholangitis exhibited the typical histological appearance, reminiscent of human primary sclerosing cholangitis. Human cholangiocytes constitutively expressed DR5, and TRAIL expression and apoptosis were significantly elevated in cholangiocytes of human primary sclerosing cholangitis and primary biliary cirrhosis patients. Thus, TRAIL/DR5-mediated apoptosis may substantially contribute to chronic cholestatic disease, particularly primary sclerosing cholangitis.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    RVK:
    RVK:
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2008
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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