In:
Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 39, No. 4 ( 2008-04), p. 1115-1120
Abstract:
Background and Purpose— Atherothrombotic diseases, including stroke and myocardial infarction, share a common pathogenesis. Chromosomal regions have been linked to atherothrombotic diseases in family studies, and association studies have identified candidate gene polymorphisms that affect the risk of stroke and/or myocardial infarction. Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families. Methods— Nonparametric linkage analysis was implemented in MERLIN, which tests for excess allele-sharing among affected siblings. Empirical distributions based on gene dropping simulations were constructed for each test statistic, and the −log 10 of the associated probability values were compared. Results— Analyses were based on 9607 individuals in 226 black, 395 Hispanic, and 207 white families; 106 families had multiple affected individuals. Several regions showed linkage to stroke or myocardial infarction, most significantly in Hispanics on chromosomes 2p21 (−log 10 P =3.0) and 7q21.1 (−log 10 P =2.8), 9q32 in blacks and Hispanics (−log 10 P =3.0), 11p13 in blacks (−log 10 P =2.1), and 12q24.33 in whites (−log 10 P =3.0). Conclusions— There is statistically significant evidence for loci affecting stroke or myocardial infarction on chromosomes 2, 9, and 12.
Type of Medium:
Online Resource
ISSN:
0039-2499
,
1524-4628
DOI:
10.1161/STROKEAHA.107.490433
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2008
detail.hit.zdb_id:
1467823-8
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