In:
British Journal of Nutrition, Cambridge University Press (CUP), Vol. 100, No. 5 ( 2008-11), p. 1054-1059
Kurzfassung:
Concerns about risks for older people with vitamin B 12 deficiency have delayed the introduction of mandatory folic acid fortification in the UK. We examined the risks of anaemia and cognitive impairment in older people with low B 12 and high folate status in the setting of voluntary fortification in the UK. Data were obtained from two cross-sectional studies ( n 2403) conducted in Oxford city and Banbury in 1995 and 2003, respectively. Associations (OR and 95 % CI) of cognitive impairment and of anaemia with low B 12 status (holotranscobalamin 〈 45 pmol/l) with or without high folate status (defined either as serum folate 〉 30 nmol/l or 〉 60 nmol/l) were estimated after adjustment for age, sex, smoking and study. Mean serum folate levels increased from 15·8 ( sd 14·7) nmol/l in 1995 to 31·1 ( sd 26·2) nmol/l in 2003. Serum folate levels were greater than 30 nmol/l in 9 % and greater than 60 nmol/l in 5 %. The association of cognitive impairment with low B 12 status was unaffected by high v. low folate status ( 〉 30 nmol/l) (OR 1·50 (95 % CI 0·91, 2·46) v. 1·45 (95 % CI 1·19, 1·76)), respectively. The associations of cognitive impairment with low B 12 status were also similar using the higher cut-off point of 60 nmol/l for folate status ((OR 2·46; 95 % CI 0·90, 6·71) v. (1·56; 95 % CI 1·30, 1·88)). There was no evidence of modification by high folate status of the associations of low B 12 with anaemia or cognitive impairment in the setting of voluntary fortification, but periodic surveys are needed to monitor fortification.
Materialart:
Online-Ressource
ISSN:
0007-1145
,
1475-2662
DOI:
10.1017/S0007114508958001
Sprache:
Englisch
Verlag:
Cambridge University Press (CUP)
Publikationsdatum:
2008
ZDB Id:
2016047-1
SSG:
12
SSG:
21
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