In:
Kidney and Blood Pressure Research, S. Karger AG, Vol. 31, No. 3 ( 2008), p. 143-151
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 Cardiothoracic ratio (CTR) is associated with left ventricular mass, left ventricular systolic dysfunction and mortality in patients with hypertension or chronic cardiovascular disease. The clinical significance of CTR in non-diabetic maintenance hemodialysis (MHD) patients remains unclear. 〈 i 〉 Methods: 〈 /i 〉 468 non-diabetic MHD patients were enrolled. Geographic, hematological, biochemical and dialysis-related data were obtained. The patients were analyzed for nutritional and inflammatory markers as well as CTR. All patients were followed up for 2 years to investigate the risks for mortality. 〈 i 〉 Results: 〈 /i 〉 Chi-square analysis showed that the incidence of malnutrition and inflammation was significantly higher in patients with CTR 〉 60% than in patients with CTR ≤60%. CTR positively correlated with high-sensitivity C-reactive protein (hsCRP) levels but negatively correlated with albumin levels. 29 patients (6.2%) had expired by the end of the study. Cox multivariate analysis revealed that CTR significantly predicts both all-cause and cardiovascular-cause 2-year mortality in non-diabetic MHD patients. 〈 i 〉 Conclusion: 〈 /i 〉 CTR is an indicator of inflammation and nutritional status in non-diabetic MHD patients and can predict 2-year mortality in these patients. The analytical results of this study support continued efforts to reduce CTR and treat underlying causes in patients with CTR 〉 50%.
Type of Medium:
Online Resource
ISSN:
1420-4096
,
1423-0143
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1482922-8
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