In:
Neurourology and Urodynamics, Wiley, Vol. 25, No. 3 ( 2006-01), p. 283-289
Abstract:
To clarify the contributions of parasympathetic inputs and outputs to the micturition reflex. Materials and Methods Intra‐vesical pressure (IVP), external urethral sphincter electromyogram (EMG), pelvic afferent nerve activities (PANA), and pelvic efferent nerve activities (PENA) as well as the time‐derived IVP (dIVP, an index of bladder contractility) were evaluated in intact and acute dorsal or ventral root(s) rhizotomized (DRX and VRX, respectively) rats. Results In DRX rats, when compared with that in intact stage, the voiding frequency was decreased (75 ± 15% of intact, P 〈 0.05, n = 8), while the threshold pressure to trigger voiding contractions was significantly increased (187 ± 75% of intact, P 〈 0.05, n = 8). In addition, several insufficient contractions (5.3 ± 3.5 contractions/voiding, P 〈 0.05, n = 8) occurred in ahead of each voiding contraction. On the other hand, in VRX rats, the peak and rebound IVP were significantly decreased (90 ± 3.5% and 75 ± 11.3% of intact, P 〈 0.01, n = 8), while the threshold pressure was not affected (102 ± 11% of intact, P = NS, n = 8). The time‐derived parameters were significantly decreased in VRX (peak dIVP, 78 ± 10.2%, rebound dIVP, 75 ± 15.6%, minimal dIVP, 68 ± 14% of intact, P 〈 0.01, n = 8) but only peak dIVP was decreased (85 ± 11% of intact, P 〈 0.01, n = 8) in DRX rats. Conclusion Acute selective DRX and VRX rat can be an animal model to investigate peripheral neural control in micturition functions. Neurourol. Urodynam. 25:283–289, 2006. © 2006 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0733-2467
,
1520-6777
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
1500793-5
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