In:
Science, American Association for the Advancement of Science (AAAS), Vol. 309, No. 5743 ( 2005-09-23), p. 2067-2070
Abstract:
Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin , a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a “negative” image of mouse enamel knots. Furthermore, we show that ectodin -deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin -deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1116848
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2005
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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