In:
Annual Review of Immunology, Annual Reviews, Vol. 23, No. 1 ( 2005-04-01), p. 651-682
Abstract:
▪ Abstract CD8 + T cells play a critical role in antiviral immunity by exerting direct antiviral activity against infected cells. Because of their ability to recognize all types of viral proteins, they offer the promise of providing broad immunity to viruses that evade humoral immunity by varying their surface proteins. Consequently, there is considerable interest in developing vaccines that elicit effective antiviral T CD8+ responses. Generating optimal vaccines ultimately requires rational design based on detailed knowledge of how T CD8+ are activated in vivo under natural circumstances. Here we review recent progress obtained largely by in vivo studies in mice to understand the mechanistic basis for activation of naive T CD8+ in virus infections. These studies point the way to detailed understanding and provide some key information for vaccine development, although much remains to be learned to enable truly rational vaccine design.
Type of Medium:
Online Resource
ISSN:
0732-0582
,
1545-3278
DOI:
10.1146/immunol.2005.23.issue-1
DOI:
10.1146/annurev.immunol.23.021704.115702
Language:
English
Publisher:
Annual Reviews
Publication Date:
2005
detail.hit.zdb_id:
1470451-1
SSG:
12
Permalink